Omicron iterates fast, can COVID-19 vaccine market learn from the "flu model"

BA.4 and BA.5, the new branches of Omicron with stronger communication power, have recently attracted attention. The new branch has triggered a new infection peak in South Africa, and the Portuguese National Institute of Health also estimates that its growth advantage is 13% more than that of BA.2.

Screenshots from the nextstrain website show that the different Omicron branches represented by yellow, orange and red are iterating rapidly within half a year, and the new branches represented by orange and red are also expanding in the cracks.

Screenshot of nextstrain website. According to the uploaded sequencing data, since December last year, the mainstream branches in Omicron have gradually changed from BA.1 (shown as 21K) to BA.2 (shown as 21L) to BA2.12.1 (shown as 22C), and the area occupied by new branches is also expanding.

The new branches of Omicron are frequent. Is the current COVID-19 vaccine still effective? Do the branches BA.2 and BA.5 need their own vaccines? Should the update of COVID-19 vaccine keep up with the variation of virus? How to keep up with the virus mutation? With the above questions, the reporter of Science and Technology Daily contacted and interviewed a number of industry experts.

Is the current vaccine still effective?

Does the mutation branch in Omicron constantly trigger new infection peaks, which means that the current COVID-19 vaccine will be invalid?

Authoritative experts in the industry responded to the Science and Technology Daily reporter and said: "Current vaccines can still provide the most basic protection in ensuring the reduction of severe illness and death.. The epidemic in COVID-19 has been going on for two and a half years. At present, it seems that there is no possibility for Covid-19 to achieve zero infection through vaccination. COVID-19 vaccine can ensure the effect of reducing infection and avoiding serious illness and death. "

Regarding the role of the current vaccine in epidemic prevention and control, the person in charge of vaccine-related production enterprises in COVID-19 holds the same view: "The existing vaccine is no problem in preventing severe illness and death at present, but it will not be 100% anti-infection."

Many statistics or research results from the real world show that the current vaccine plays a significant role in preventing severe illness and death. For example, the latest data in Hong Kong (as of May 25th) showed that the mortality rate of those infected in Omicron who were not vaccinated was 3.04%, while the mortality rate of those infected with three doses of vaccine dropped significantly to 0.04%.

Do the branches BA.2 and BA.5 all need their own vaccines?

According to WHO’s latest weekly report on epidemiological progress in COVID-19 (May 25th),Omicron BA.2 and its progeny pedigree (BA.2.X) have become the main popular variants in the world.At present, the relative proportions of BA.2.X, BA.4 and BA.5 are 94%, 0.8% and 1% respectively.

This shows that during the evolution of Omicron mutant, the branch BA.1 is disappearing. However, the reporter learned that at present, most vaccines against Omicron in China are designed and developed for BA.1.

Whether it is necessary to develop new vaccines for new branches, the industry generally judges from the perspective of vaccine protection: if the activity of neutralizing antibodies produced by the original vaccines against mutant strains is greatly reduced, it is necessary to develop new vaccines; If it still has a good neutralizing effect on the mutant, there is no need to develop a new vaccine.

Although Omicron strain mutates rapidly and different branches appear, butNew vaccines will not be introduced for each branch, and there is no need to do so.. Relevant experts reminded: "If you continue to monitor, you will find that many mutations will disappear soon."

Can vaccine update keep up with virus iteration?

In the technical route of vaccine development in COVID-19, the design cycle of mRNA vaccine is short. On the basis of a mature platform, the design can be completed within 7 days, and the preclinical trials including animal experiments can be completed in about one month.

Industry experts engaged in the research and development of mRNA vaccine said that for the variant branch, the mRNA vaccine does not need to obtain the strain, but only needs to optimize the vaccine sequence according to the variant sequence and test the expression efficiency, and then pre-clinical trials can be carried out. Covid-19 Omicron mutant mRNA vaccine, developed by Suzhou Aibo Bio, China, has been approved for clinical research in UAE.

In response to virus variation, the technical route of inactivated vaccine can also complete the preclinical study of new strains in a short time by establishing an emergency system. The reporter previously learned that it can be advanced to the clinical trial application stage about 2 months after obtaining the new strain.

Keep up with the variation, can COVID-19’s vaccine market learn from the "flu model"

In order to cope with the frequent mutation of viruses, there are precedents for vaccine updates to follow closely. For example, the influenza virus vaccine is recommended by WHO every year, and countries produce new influenza vaccines accordingly.

In order to keep up with the variation in Covid-19, can the "flu model" be used for reference in the marketing of vaccines in COVID-19?

It is estimated that the future development of COVID-19 vaccine needs to adopt the influenza model.The authoritative experts mentioned above responded, but WHO is unable to recommend mainstream strains through monitoring now, because the pandemic is not over yet.

Another advantage of the "flu model" is that it greatly shortens the time to market for new vaccines. Because there is no need for re-approval, its batch issuance system can effectively shorten the period from vaccine development to marketing. Experts in the industry said that after polishing and construction, various technical routes and platforms have gradually matured, the research and development speed has been accelerated, and the production process has been stable.If the "flu model" can be adopted in the development and marketing of vaccines in COVID-19, the time to market for new vaccines will be greatly shortened.

WHO has revealed some unexpected phenomena in its weekly epidemiological report: available data show that BA.4, BA.5 and BA.2.12.1 spread faster in countries where BA.1 was once prevalent, but less in countries where BA.2 was prevalent; The vaccination degree of each country may have an impact on the popularity of the new branch of Omicron. Visible,Covid-19 mutation and vaccine immunogenicity are mutually causal and widely related, and updating the vaccine in time may have an impact on virus mutation.

Source: Science and Technology Daily

Original title: "Omicron iterates fast, is it necessary to be" anxious "about the vaccine? 》

Read the original text

Notice of the General Office of Beijing Municipal People’s Government on prohibiting the stocking of birds and animals that affect flight safety in the clearance protection area of Capital Internation

Beijing Zhengban Fa [2008] No.1

The people’s governments of the districts and counties, the commissions, offices and bureaus of the municipal government, and the municipal institutions:

  In recent years, the civil aviation planes of Capital International Airport (hereinafter referred to as Capital Airport) have been repeatedly hit by pigeons raised and released in the surrounding areas, especially since 1998, and such incidents have been on the rise, which has seriously endangered the flight safety of civil aviation. With the rapid growth of the flight volume of the Capital Airport and the approaching of the Beijing Olympic Games in 2008, in order to eliminate the hidden danger of bird strikes against aircraft in the clearance protection area of the Capital Airport and ensure the flight safety of civil aviation, according to the Civil Aviation Law of People’s Republic of China (PRC), the Notice of the General Office of the State Council on Strengthening the Management of Civil Aviation Flight Safety (Guo Ban Fa [2004] No.37) and other relevant regulations, with the consent of the municipal government, the relevant matters are hereby notified as follows:

  1. According to the Convention on International Civil Aviation, the national civil aviation industry standard "Technical Standard for Civil Airport Flight Areas" (MH5001-2006) and other relevant regulations, the clearance protection area of the Capital Airport is 35.8 kilometers long from north to south, 15.9 kilometers wide from east to west, and covers an area of about 257.72 square kilometers (see Annex for specific coverage).

  2. In the clearance protection area of the Capital Airport, it is strictly forbidden to raise and fly pigeons and other birds and animals (hereinafter referred to as birds and animals) that affect flight safety. Outside the clearance protection area of the Capital Airport, when flying birds and animals, no unit or individual may fly through the clearance protection area of the Capital Airport.

  3. In the planned land use scope and clearance protection area of the Capital Airport, the industrial and commercial departments shall not register enterprises and individual industrial and commercial households engaged in raising and releasing birds and animals according to law. Within the planned land area of the Capital Airport, if bird activities endangering flight safety occur, the airport management agency shall take eviction or other necessary measures to deal with them. Outside the planned land use scope of the Capital Airport and within the clearance protection area, the local district government is responsible for building dovecotes and raising, flying and operating birds and animals without a license in violation of relevant regulations, and organizes urban management and law enforcement, public security, industry and commerce and other relevant departments, neighborhood offices and township governments to investigate and deal with them according to law.

  Fourth, the carrier pigeon association should do a good job in the organization and management of its members, sheds, clubs, etc., and supervise them to strictly abide by the relevant regulations when raising and flying carrier pigeons and organizing racing competitions, so as not to affect flight safety.

  Five, civil aviation, public security, urban management and law enforcement, industry and commerce departments should earnestly perform their respective duties, and in accordance with the Civil Aviation Law of People’s Republic of China (PRC), the Law of People’s Republic of China (PRC) on Public Security Administration Punishment, the Measures for Investigating and Banning Unlicensed Business (Order No.370 of the State Council), and the Regulations of Beijing Municipality on City Appearance and Environmental Sanitation, etc., the illegal acts shall be punished, and criminal responsibility shall be investigated according to law.

  Attachment: Scope of Clearance Protection Area of Capital Airport

  January 4th, 2008  

Attachment:

Scope of clearance protection area of Capital Airport

  According to the Convention on International Civil Aviation, the national civil aviation industry standard "Technical Standard of Civil Airport Flight Area" (MH5001-2006) and other relevant regulations, the clearance protection area of the Capital Airport is 6 kilometers on both sides of each runway and 15 kilometers at both ends. According to the final planning of the four runways, the clearance protection area of the Capital Airport is 35.8 kilometers long from north to south and 15.9 kilometers wide from east to west, with a total area of about 257.72 square kilometers in the east to Linhe Industrial Zone in Renhe District, Shunyi District, fan village in Yongshun District, Tongzhou District, Luogezhuang Village in Houshayu District, Shunyi District, and Baofang Village in Zhaoquanying Town, Shunyi District. It covers 3 streets, 6 districts, 1 industrial zone, 38 communities and 98 administrative villages under the jurisdiction of 3 towns in Shunyi District, 1 street in Chaoyang District, 6 communities and 26 administrative villages under the jurisdiction of 4 districts, and 9 administrative villages under the jurisdiction of 1 district and 1 town in Tongzhou District. The details are as follows:

  I. Scope of Clearance Protection Area in Shunyi District

  (1) Sixteen communities in Shengli Street: Xingfu West Street Community, Yibin Street Community, Yibin Building First Community, Yibin Building Second Community, Qianjin Community, Taiping Community, Shengli Community, Shuangxing West District First Community, Shuangxing West District Second Community, Xixin Community, Xixin First Community, Dongxing Community First Community, Dongxing Community Second Community, Dongxing Community Third Community, Shuangxing East Community, Happiness.

  (2) Nine communities in Guangming Street: Binhe Community, Yulong garden club, Family Committee of 66055 Army, First Community in New North District, Second Community in New North District, Third Community in New North District, First Community in New South District, Second Community in New South District and Sixth Community in Yulong District.

  (3) Ten communities in Shiyuan Street: Wulicang No.1 Community, Wulicang No.2 Community, Shiyuan West Community, Shiyuan East Community, Shiyuan North District No.1 Community, Shiyuan North District No.2 Community, Shiyuan South Community, Light Automobile Committee, Yanjing Beer Manufacturers Committee and Shiyuan East Community.

  (4) Linhe Industrial Zone and 19 administrative villages in Renhe District: Shigezhuang Village, Qianjin Village, Fuxing Village, Taiping Village, Zhuangtou Village, Shimen Village, Shajing Village, Wangquansi Village, Junying Village, Meigouying Village, Shatuo Village, Hugezhuang Village, Yangjiaying Village, Wujiaying Village, Migezhuang Village, Yaopo Village, Taojiafen Village and Pinggezhuang Village.

  (5) Fourteen administrative villages in Houshayu area: Luogezhuang Village, Xitian Gezhuang Village, Yanwangzhuang Village, Xibai Xinzhuang Village, Jixiangzhuang Village, Matouzhuang Village, Houshayu Village, Qianshayu Village, Dongzhuang Village, Huoshenying Village, Blacksmith Ying Village, Kuliushu Village, Huimin Ying Village and Donggezhuang Village.

  (6) Two communities and eight administrative villages in Tianzhu area: Lianzhu garden club, Lianzhu Garden Second Community, Tianzhu Village, Xuedarenzhuang Village, Loutai Village, Gangshan Village, Yang Er Ying Village, Hualikan Village, Ershilipu Village and Xiaowang Xinzhuang Village.

  (7) Eleven administrative villages in South Faxin area: hong cun in Donghai, hong cun in Xihai, Nanjuan Village, Sanjiadian Village, Dongdulan Village, Xidulan Village, Beifaxin Village, Jiaogezhuang Village, Dajiangwa Village, Liujiahe Village and South Faxin Village.

  (8) Eleven administrative villages in Ma Po: Liangzhengjuan Village, Miaoerjuan Village, Yamen Village, Shijiaying Village, Maojiaying Village, Yaodian Village, Majuan Village, Jingjuan Village, West Ma Po Village, Baigezhuang Village and Nihe Village.

  (9) Five administrative villages in Niulanshan area: Qianyanzi Village, Yaogezhuang Village, Xianggezhuang Village, Guanzhijuan Village and Fangezhuang Village.

  (10) Seven administrative villages in Gaoliying Town: Zhangxizhuang Village, Dongmagezhuang Village, Ximagezhuang Village, Xiaxianying Village, Nanlangzhong Village, Shuipo Village and Wenying Village.

  (11) One community and nine administrative villages in Liqiao Town: Sakura Garden Community, Yinggezhuang Village, Nanbanbidian Village, Houqiao Village, Zhuangzi Ying Village, Wazi Village, Touerying Village, Sansiying Village, Zhangxin Village and Xishuxing Village.

  12. The 14 administrative villages in Zhaoquanying Town: xi xiao ying, Beilangzhong Village, Qiansangyuan Village, Housangyuan Village, Baimiao Village, Majiapu Village, Daguanzhuang Village, xiaoguanzhuang Village, Xichengezhuang Village, Zhaoquanying Village, Baofang Village, Jishanying Village, Xijiangyouying Village and Banqiao Village.  

       II. Scope of Clearance Protection Area in Chaoyang District

  (1) Four communities in the streets of the Capital Airport: South Road Xili Community, South Road Dongli Community, Xiping Street Community and Nanping Li Community.

  (2) There are 2 residential areas and 13 administrative villages in Jinzhan area: Chaoyang Farm Residential Area, No.16 Engineering Office Residential Area, Leizhuang Village, Dongcun Village, Xicun Village, Xiaodian Village, Beimafang Village, Louzizhuang Village, Shawo Village, Ligezhuang Village, Magezhuang Village, Picun Village, Dongyao Village, Caogezhuang Village and Gaoantun Village.

  (3) Six administrative villages in Sunhe area: Sunhe Village, Qianweigou Village, Houweigou Village, Kangying Village, Beidian Village and Xidian Village.

  (4) Four administrative villages in Dongba area: Sanchahe Village, Jiaozhuang Village, Dongxiaojing Village and Xixiaojing Village.

  (5) Three administrative villages in Changying Hui area: Shilipu Village, Wuliqiao Village and Caofang Village.

  III. Scope of Clearance Protection Area in Tongzhou District

  (1) Three administrative villages in Yongshun area: Beimazhuang Village, fan village Village and Wangjiachang Village.

  (2) Six administrative villages in songzhuang town: Guantou Village, Wugezhuang Village, Gequ Village, Yingezhuang Village, Regal Village and Zhaili Village.

North American box office: "Mr. Glass" topped the "Dragon Ball Super" fans.

1905 movie network news Last weekend (01.18-01.20), the box office revenue in North America totaled $129 million, up 8.2% from the previous week. Monday is Martin Luther King Memorial Day, and we will continue to have a holiday. Among the new films on the list, M Knight Shamalan’s new film "Mr. Glass" earned $40.58 million in the first three days of the first weekend, which was close to $40.01 million in the first week of "Split" in 2017 and higher than $30.33 million in the first week of "Never Die" in 2000. Not surprised or pleased. The media mostly think that the content is too full and too anxious, but there is no emotional touch. They think that they are not attracted to fans of "The Dead Robber" or "Split" and become ungrateful at both ends. Another new film is a slightly niche animated film "Dragon Ball Super: brolly". The plot is based on the animated series "Dragon Ball". After telling the story of Wukong and brolly, it is biased towards fans. In the first week, it won 10.65 million US dollars in 1233 theaters in North America, but it attracted a limited audience and was not optimistic about its subsequent box office development.

ranking

film

Weekend box office

(USD)

Cumulative box office

(USD)

Number of release weeks

this week

last week

one

new

Mr. glass

40.58 million

40.58 million

one

2

one

Uplink

15.67 million

43.98 million

2

three

new

Dragon Ball Super: brolly

10.65 million

21.07 million

one

four

2

Aquaman

10.33 million

304.3 million

five

five

four

Spider-Man: Into the Spider-Verse

7.25 million

158.2 million

six

six

three

A dog’s way home

7.11 million

21.27 million

2

seven

five

Escape Room

5.27 million

40.7 million

three

eight

six

Happy Man 2

5.24 million

158.7 million

five

nine

seven

Bumblebee

4.66 million

111.5 million

five

10

eight

Gender-oriented

3.96 million

16.87 million

four

11

nine

Mule

3.5 million

96.92 million

six

twelve

15

Green Book

2.26 million

41.97 million

10

Source: boxofficemojo


"Mr. Glass" is too full of word of mouth, and the fans of "Dragon Ball Super: brolly" are serious


Recommended star rating of Mr. Glass: ★★★

"Dragon Ball Super: brolly" Recommended star rating: ★★★ (specific fan direction)

 

On the weekend of Martin Luther King’s Day, M Knight Shamalan’s new work "Mr. Glass" earned 40.58 million US dollars at the box office in North America from Friday to Sunday, which was close to 40.01 million US dollars in the first week of "Split" in 2017 and higher than 30.33 million US dollars in the first week of "Never Die" in 2000. In all the Martin Luther King Memorial Weekends, this box office ranked third, only behind the $41 million of "Sasaki Brothers" in 2014 and the $89 million of "American Sniper" in 2015. The production cost of Mr. Glass is $20 million, and the global box office has reached $90 million. These figures undoubtedly prove Shamalan’s ability to make money again. In fact, even in the low tide of Shamalan’s poor reputation, many of his films were very profitable. For example, in 2008, the production cost of "Death" was 48 million US dollars, and the final global box office was 163 million US dollars. In 2004, the production cost of "Mystery Village" was 60 million US dollars, and the final global box office was 256 million US dollars. What he really didn’t earn was only.

 

At present, the cinema score of Mr. Glass is B, IMDb score is 7.2, MTC score is 42, and the freshness of rotten tomatoes is 36%. "Hollywood Reporter" commented: "As the final part of the trilogy, this film is like a mixed bag, twisting all the previous narrative clues into one, but unfortunately trying too hard to tell the audience that Shamalan has a very special idea on the popular comic adaptation story, but the result is not shown." "Variety" said: "It’s still very happy to see Shamalan return, but" Mr. Glass "takes up more of our time, but it can’t create any touches, which makes people feel busy and dazzling, but there are few moving moments of emotional resonance." "International Screen" thinks: "Apart from McEvoy’s performance as a smoke bomb and Bruce Willis’s convincing charm, the whole film has actually not gone far in the concept of’ what happens when people become superheroes’." Due to the poor reputation, the follow-up box office track of Mr. Glass may be more similar to the Clover Files, which was opened on the weekend of Martin Luther King’s Day in 2008. The film earned $40 million in the first week and $80 million in the local box office.

Another noteworthy new film last weekend was the classic IP cartoon "Dragon Ball Super: brolly", which was only opened in 1,233 theaters in North America, aiming at clearly attracting a specific fan base, and won $10.65 million at the box office in three days in the first weekend. The story of "Dragon Ball Super: brolly" is a continuation of the upcoming TV animation "Dragon Ball", which tells the story between Saiyan brolly and Wukong. The film was nominated for the best cartoon in the 42nd Japanese Film Academy Award and was very popular among fans. At present, the media scores and fans’ scores of all platforms are very high, with IMDb score of 8.6, MTC score of 64 and the freshness of rotten tomatoes of 80%. The Los Angeles Times said: "brolly is ready to give Dragon Ball fans everything they want in a movie, and other viewers may feel lost in this world." Midwest Film Journal also thinks: "For the novice Dragon Ball, this film provides a dazzling animation time." There are also some media that don’t like it, such as "Movie Country", which means: "This is a meaningless garbage culture animation only for fans."

 

Old movies: "Neptune" local over 300 million "Upward" has a strong box office stamina.

 

Warner Bros.’ s superhero movie Neptune has entered its fifth week. After the weekend, the film’s box office outside North Captain America: Civil War has reached 759 million US dollars, surpassing’s 745 million US dollars, and the local box office has also exceeded 300 million US dollars. At present, the film’s global total box office is 1.063 billion US dollars, which is still 3 million US dollars short. Amber Heard’s Neptune can surpass Johnny Depp’s highest-grossing Pirates of the Caribbean: The Coffin. At the same time, Aquaman is also the movie with the strongest box office stamina after Teenage Mutant Ninja Turtles: The Age of Mutations in 2014. It is expected that Aquaman will have a good room for growth before The Lego Movie 2: The Second Part and Listen to Men’s Hearts come out on February 8.

 

In the following week, Upward Bound kept quite steady, with the box office of $15.6 million in three days over the weekend, which was only 23% lower than that in the first week. Earlier, many films in kevin hart fought bravely in Martin Luther King’s weekend, such as the above-mentioned Sasaki Brothers, Customized Best Man and Sasaki Brothers 2, and so on. This time, Upward Bound was opened in this schedule one week ahead of schedule. At present, the total box office of Upward is US$ 43.98 million. As long as it exceeds the US$ 48.7 million of Supersize Beauty last year, it will become the third domestic box office of STX Entertainment after bad mother and Christmas of Bad Mom. Sony’s Spider-Man: Into the Spider-Verse currently has a global box office of US$ 322 million, which has surpassed The LEGO Batman Movie’s US$ 311 million. The production cost of Spider-Man is US$ 90 million.

 

This week’s preview: Adventure "King Boy" Playing through the thriller "Quiet" arouses expectations.


This weekend (01.25-01.27), Fox’s youth movie "King Boy" and Matthew McConaughey and Anne Hathaway’s crime thriller "Quiet" will be widely opened in North America.

 

Fox’s "The King’s Boy" tells the story of a little fat boy, Alex, who accidentally pulls out and passes on the "sword in the stone" mentioned by H. As a destined little hero, he needs to unite his friends and the legendary wizard Merlin to fight against the eccentric witch Morgana. This is a story from modern times to legend, which will be opened in more than 3,400 theaters in North America this Friday. The crime thriller "Quiet" starring Matthew McConaughey and Anne Hathaway was postponed from last October to this week. It tells the story that Baker Dill, the captain of a fishing boat, received a request from his ex-wife Karen to help her kill her violent current husband. Karen’s appearance was forgotten in Jandyr, but in fact, the current situation is also city by the sea. The film will open in more than 2500 theaters this Friday.


Mary said that the Spring Festival Evening was like an exam, and Zhang Yimou was like a god to himself.

On February 9th, Mary, the actor who made his eighth appearance on the stage of the Spring Festival Evening, came to the interview room. She said that every time she comes to the Spring Festival Gala, like the exam, she is particularly nervous and under great pressure. When she has good works, she will be more confident in acting, but this year’s time is relatively hasty.

Mary said that it is actually more difficult for an actress to act in comedy than an actor, because she is not willing to "sell" or "play", but rather wants to start from the characters, so whether it is the structure or the character of the role, it is still more challenging to act.

Talking about the upcoming film Article 20, Mary said that he didn’t expect to cooperate with director Zhang Yimou one day. From the day he joined the group, he felt that everything was like a dream. Mary also said that Zhang Yimou’s state of filming on the spot, his unique ideas, his requirements for actors and his control of all the plays made him feel that the director is the most attractive and soul person in the crew and the soul of a movie. "I think the director is like a god to me."

Recalling that in 2023, Mary admitted that he was a model worker. Last year, there were 3 or 4 films and played some very powerful female roles. The creative process was happy, but it was also very painful. The result was very satisfactory for himself. I hope I can give myself a holiday in the new year.

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Li Hui, the representative of the 19th National Congress: Protecting Green Water and Castle Peak with Iron Fist Pollution Control

Li Hui, deputy of the 19th National Congress and secretary of Yongzhou Municipal Committee of Hunan Province, was interviewed by CCTV reporters.

Li Hui, deputy of the 19th National Congress and secretary of Yongzhou Municipal Committee of Hunan Province, was interviewed by CCTV reporters.

  Cctv news(Reporter Tang Shiying, Liu Chunyu, Li Wenxue) "Since the 18th National Congress of the Communist Party of China, our urban and rural appearance has undergone gratifying changes. For ordinary people, the sense of gain is getting stronger and stronger, and there have been great changes in eating and living, and the smiles of ordinary people are brighter!" Li Hui, deputy of the 19th National Congress and secretary of the Yongzhou Municipal Committee of Hunan Province, said that it is the duty of a local responsible comrade to study the report of the 19th National Congress carefully. "After I go back, I will pass the voice of the party to every party member at the first time."

  Yongzhou City is located at the source of Xiangjiang River. In recent years, Yongzhou City has actively integrated into the development mode of "green development and green life". The excellent air quality rate has reached more than 90% all the year round. From January to September this year, the excellent air quality rate ranked first in the province; The city’s forest coverage rate reached 64.7%, with 8 national forest parks, 8 national wetland parks and 4 national nature reserves; The city’s surface water environmental function zones, drinking water sources and urban centralized drinking water sources have reached the standard rate of 100%. Up to now, the water quality of the Xiangjiang River has maintained the Class II water standard for 64 consecutive months, realizing the "Xiangjiang River going north and flooding the river". Ecological advantages and green advantages are accelerating into development advantages.

  Deputy Li Hui said that the changes and development of Yongzhou in recent years are due to the "four persistences" and the insistence on green development as the top priority. During the "Thirteenth Five-Year Plan" period, the city deployed 83 key ecological and environmental protection projects with a total investment of 104.2 billion yuan; Adhere to the ecological red line as the bottom line of politics. In recent years, Yongzhou City vetoed 72 projects to be stationed, with a planned total investment of more than 10 billion yuan; Insist on industrial transformation as a fundamental solution. Since 2015, Xiangjiang Paper, which has a history of nearly 60 years, has been shut down and transferred with an annual output value of nearly 1 billion yuan and a tax revenue of more than 100 million yuan. Adhere to the ecological accountability as a sharp weapon, strictly fulfill the "one post and two responsibilities", take the construction of ecological civilization and ecological priority development as the key contents of the "potential performance" assessment, and include them in the performance assessment of leading bodies and the assessment of leading cadres’ execution, so as to lead the green development with the assessment of "baton".

Li Hui, secretary of Yongzhou Municipal Committee of Hunan Province, accepted an exclusive interview with CCTV reporters.

Li Hui, secretary of Yongzhou Municipal Committee of Hunan Province, accepted an exclusive interview with CCTV reporters.

  It is such a series of measures that make Yongzhou’s ecological management and protection come to the forefront of the whole province and even the whole country.

  The report of the 19th National Congress of the Communist Party of China made a new plan of "accelerating the reform of ecological civilization system and building a beautiful China". Deputy Li Hui said that the concept of "Lucid waters and lush mountains are invaluable assets" should be firmly established, and ecological protection and economic and social development should be planned and deployed together.

  Yongzhou will conscientiously implement the spirit of the 19th National Congress of the Communist Party of China, insist on guarding the green mountains with an iron fist, promote green upgrading with industrial upgrading, write a green answer sheet with reform and innovation, and cultivate green development with green culture to ensure that Yongzhou has bluer sky, clearer water and greener mountains.

  Deputy Li Hui said that in the next step, Yongzhou will also vigorously implement the strategy of "innovation leading the rise of openness", focus on building "a new highland of innovation and opening up, a new Yongzhou with quality and vitality", highlight the "six major battles" and strive to achieve "four upgrades". Strive to reach the forefront of the province’s second phalanx in comprehensive economic strength by 2022, with an average annual growth rate of 9%, reaching about 350 billion yuan and a per capita GDP of 10,000 US dollars; The total fiscal revenue increased by 15% annually, and the total amount doubled compared with 2017, exceeding 35 billion yuan; The per capita disposable income of urban residents is close to 50 thousand yuan, and the per capita net income of farmers exceeds 15 thousand yuan; It will be built into an inter-provincial regional central city of Hunan, Guangdong and Guangxi, a national civilized city, a national garden city, a national global tourism demonstration city and a world shoemaking capital.

Implementation Opinions of the General Office of Guangdong Provincial People’s Government on Promoting and Standardizing the Development of Big Data Application in Health Care

  
General Office of Guangdong Provincial People’s Government on Promoting and Standardizing

Implementation opinions on the application and development of big data in health care

People’s governments at the local level and listed, people’s governments of counties (cities, districts), departments and institutions directly under the provincial government:

  In order to implement the Guiding Opinions of the General Office of the State Council on Promoting and Standardizing the Application and Development of Big Data in Health Care (Guo Ban Fa [2016] No.47), adapt to the development trend of big data technology, promote and standardize the integration, sharing and open application of big data in health care, improve the medical service capacity and improve the health level of the people, with the consent of the provincial people’s government, we hereby put forward the following implementation opinions.
  I. General requirements

  (1) Guiding ideology. We will fully implement the spirit of the 18th CPC National Congress and the Third, Fourth, Fifth and Sixth Plenary Sessions of the 18th CPC Central Committee, thoroughly implement the spirit of the series of important speeches by the Supreme Leader General Secretary and the new ideas, new ideas and new strategies for governing the country, conscientiously implement the decision-making arrangements of the CPC Central Committee, the State Council, the provincial party committee and the provincial government, adhere to the concept of innovation, coordination, green, openness and shared development, take the protection of people’s health as the starting point, adhere to people-oriented, innovation-driven, standardized, orderly, safe and controllable, The principle of open integration, co-construction and sharing, consolidate the grassroots foundation, improve the policy system, innovate the working mechanism, vigorously promote the interconnection, integration and open sharing of government health care information systems and public health care data, fully stimulate the innovation vitality of health care big data, explore new applications of data, innovate new service models, foster and develop new formats, provide strong support for building a strong health province and a healthy Guangdong, and make positive contributions to achieving the goal of "three orientations and two firsts".
  (2) objectives and tasks.
  —— By the end of 2017, a provincial-level comprehensive health information management platform with complete functions and unified authority will be initially established to realize interconnection with the national population health information platform. Realize the interconnection between the provincial drug bidding and purchasing business application supervision platform and the national drug supply security comprehensive management information platform.
  —— By the end of 2018, all the listed and county (city, district) national health information comprehensive management platforms have been built at all levels, and connected with provincial platforms, forming an efficient and unified network covering all kinds of medical and health family planning institutions at all levels, and realizing business application interconnection, information sharing and effective collaboration.
  —— By the end of 2020, the province’s health care data will be shared with basic data resources such as population, legal person, spatial geography and environment across departments and regions, and the data fusion application in medical care, medicine, medical insurance and health-related fields will achieve remarkable results, and the new format of health care big data application will flourish, initially forming a health care big data industry system. Health care big data application standard system, data security and privacy protection system, relevant policies and regulations have been continuously improved, the quality of health care services has been significantly improved, and the people have received more benefits.
  Second, accelerate the construction of a shared and open health care big data application infrastructure system.

  (1) Accelerate the construction of "one network, three platforms and three databases". Strengthen the top-level design and implement the Guangdong "Healthy Cloud" service plan. Integrate and utilize existing facilities and resources such as e-government extranet, network operator network and government cloud resources, and accelerate the construction to form a private network for health care services covering provinces, cities, counties (districts), townships (towns) and villages (residences). We will build a unified and authoritative comprehensive management platform for national health information at the provincial, municipal and county levels, connect all kinds of medical and health institutions at all levels, and strengthen data collection, integrated sharing and business collaboration of application information systems such as public health, family planning, medical services, medical security, drug supply and comprehensive management. Strengthen the maturity evaluation of interconnection of the comprehensive management platform of national health information at city and county levels, and improve the level of interconnection. Establish three unified databases of the whole province, namely, full population, electronic health records of residents and electronic medical records, and build a provincial-level national health big data center with the three databases as the core. (Provincial Health and Family Planning Commission, Development and Reform Commission, the municipal people’s government is responsible for all localities, and the Provincial Economic and Information Commission, the Public Security Department, the Department of Finance, the Department of Human Resources and Social Security, and the Food and Drug Administration cooperate, and the first department is the lead department, the same below)
  (two) to speed up the upgrading of medical and health institutions information system. Accelerate the transformation and upgrading of the information system of medical and health institutions with electronic medical records as the core, reduce repeated investment and improve the efficiency of information construction. To break the data chimney formed by vertical business information system and the data island formed by isolated business information system, the information systems of medical and health institutions at all levels should all be connected with the comprehensive management platform of national health information of provinces, cities and counties, and realize data fusion within medical and health institutions and data sharing between medical institutions and between medical institutions and public health institutions. Strengthen the maturity of information system interconnection and evaluation of the application level of electronic medical record system in medical and health institutions, and improve the application level of electronic medical record. (Provincial Health and Family Planning Commission, the municipal people’s governments at all levels are responsible, and the Provincial Development and Reform Commission, the Economic and Information Commission, the Finance Department and the Human Resources and Social Security Department cooperate)
  (3) Establish a mechanism for the collection, sharing and opening of health care data.
  Promote the interconnection of the government health care information system with the three databases of the whole province’s population, residents’ electronic health records and electronic medical records, share data, and cooperate with business applications efficiently. Effectively collect data on medical services, traditional Chinese medicine, biomedicine, insurance supervision, research and development and management of drugs and medical equipment, inspection and quarantine, public health, population management, education and scientific research, food and agriculture, meteorological environment, physical fitness, etc., support management model innovation and e-government development, and realize the collection of health care data, business matters and health decision-making on the platform. (Provincial Health and Family Planning Commission, Economic and Information Technology Commission are responsible, and all relevant units cooperate)
  Combined with the needs of the "one-door, one-network" government service model, we will further promote the sharing of government data related to population and health, and smooth the data sharing channel. The establishment of centralized management of health and family planning departments, Chinese medicine, development and reform, education, science and technology, economy and informatization, public security, civil affairs, human resources and social security, environmental protection, agriculture, commerce, safety supervision, inspection and quarantine, food and drug supervision, sports, statistics, tourism, meteorology, insurance supervision, Disabled Persons’ Federation and other departments closely cooperate with the regular exchange and sharing mechanism of health and medical data. (Provincial Health and Family Planning Commission, Economic and Information Technology Commission are responsible, and all relevant units cooperate)
  Strengthen data quality management, establish and improve the standards of health care data collection, cleaning, warehousing and storage, establish a data quality evaluation mechanism, insist on controlling data quality from the source, and ensure that health care data is legal, authentic, effective and available. Explore the development of desensitization and opening methods for residents’ health care privacy information, build and improve the open platform for health care data, smooth the open channels of data, and steadily promote the opening of health care big data. Explore the establishment of Guangdong health care data resource catalogue system, and make a good connection with the national health care data resource catalogue. (The Provincial Health and Family Planning Commission is responsible, and the Provincial Development and Reform Commission, the Economic and Information Commission and the Legislative Affairs Office cooperate)
  Third, comprehensively deepen the application of big data in health care

  (1) Promote the application of governance big data in the health care industry.
  Establish and improve the monitoring and evaluation index system and evaluation model for deepening the reform of medical and health system, realize real-time monitoring of key indicators such as medical service price, medical insurance financing and payment, control of residents’ medical burden, and drug use, deepen the accurate evaluation of the reform effect of medical and health system, and improve the pertinence and effectiveness of reform decisions. Strengthen the application of evaluation and monitoring results, and promote the formation of a new model of health management decision-making based on data, such as industry supervision, performance evaluation, input compensation and personnel compensation. (Responsible for the Provincial Health and Family Planning Commission, with the cooperation of the Provincial Development and Reform Commission, the Department of Finance and the Department of Human Resources and Social Security)
  Open the data channel between medical institution management information system and clinical information system, integrate and analyze clinical, operation, cost accounting and quality evaluation data, build an evaluation system of medical institutions with comprehensive information, scientific evaluation, authoritative conclusion and timely update, improve the authority and credibility of evaluation results, and link it with hospital evaluation, fund allocation, performance pay, etc., promote the deepening of public hospital reform, improve modern hospital management system, and promote the improvement of hospital operation management level and medical service quality. (Responsible for the Provincial Health and Family Planning Commission, with the cooperation of the Provincial Development and Reform Commission, the Department of Finance and the Department of Human Resources and Social Security)
  We will improve the monitoring mechanism for the income composition and changing trend of medical institutions, such as medical care, medicines and medical consumables, and cooperate with business information such as medical service price, medical insurance payment, bidding and purchasing of medicines and medical consumables, drug use and medical expense control, strengthen the monitoring and early warning of anti-fraud of medical insurance, and promote the joint reform of medical care, medical insurance and medicine. Accelerate the integration of comprehensive supervision information on health and family planning, realize the interconnection between comprehensive supervision and law enforcement information and health care related information systems, and improve the level of industry supervision. (The Provincial Health and Family Planning Commission is responsible, with the cooperation of the Provincial Development and Reform Commission, the Economic and Information Commission, the Department of Finance, the Department of Human Resources and Social Security, the Food and Drug Administration and the Bureau of Traditional Chinese Medicine)
  (2) Promote the application of big data in clinical medical care and scientific research. Make full use of national key clinical specialties, provincial key clinical specialties, national and provincial key laboratories and other advantageous resources, rely on the National Clinical Medical Research Center, the National Traditional Chinese Medicine Data Center and the collaborative research network, base on South China, face Hong Kong, Macao and Taiwan, and radiate to Southeast Asia, and build a number of regional clinical medical data demonstration centers in the directions of cardiovascular and cerebrovascular diseases, tumors, geriatric diseases, respiratory diseases, nephropathy, reproduction, orthopedics, hepatobiliary, pediatrics, maternal and child health care, occupational diseases and traditional Chinese medicine. Strengthen the integration and sharing of clinical medicine and basic medical research data resources, and improve the transformation and application efficiency of medical research. Relying on clinical medical data demonstration center, integrating medical service data, drug research and development evaluation and management data, traditional Chinese medicine data and biomedical data, developing clinical decision support system to support clinicians to improve work efficiency and diagnosis and treatment quality. Promote the application of biomedical technologies such as gene chip and sequencing technology in genetic disease diagnosis, early cancer diagnosis and disease prevention and detection, realize the effective docking of genome information and electronic medical records, and promote the development of precision medical technology. Establish a genome database and a database of specialized subjects and diseases, and promote the research and application of disease markers. Create a number of precision medical specialties and precision medical pilot hospitals. (The Provincial Health and Family Planning Commission and the Chinese Medicine Bureau are responsible, and the Provincial Development and Reform Commission, the Economic and Information Commission, the Science and Technology Department and the Food and Drug Administration cooperate)
  (3) Promote the application of public health big data. Promote the interconnection between various national special newspaper information systems and the comprehensive management platform of national health information at the provincial, city and county levels. We will improve information systems such as immunization planning, online direct reporting, online first aid, management and treatment of severe mental disorders, prevention and control of occupational diseases, early warning and decision-making of public health risks at ports, and the application functions of mobile emergency business platforms, so as to enhance the ability of public health monitoring, evaluation and decision-making management. Integrate social network public information resources and improve the early warning mechanism of disease-sensitive information. Strengthen cooperation with the World Health Organization, international and public health institutions in Hong Kong, Macao and Taiwan, carry out research on the frontier technology of public health information, early warning and prediction research on the risk of sudden acute infectious diseases of international concern, and timely grasp and dynamically analyze the international public health risks such as the disease occurrence trend of the whole population and the global epidemic information of infectious diseases. Promote the information acquisition and information sharing of entry personnel in countries and regions where the epidemic broke out in advance, strengthen the business cooperation of inspection and quarantine, public health, foreign affairs, commerce, tourism, customs, port border inspection, maritime affairs, medical care, civil aviation, port services, railways and other units, prevent and control the imported epidemic, and improve the early warning and emergency response capabilities of public health emergencies. Promote the sharing of monitoring data of drug use, environmental sanitation, epidemiological factors monitoring, insect vector monitoring, drinking water, health hazard factors, port medical vector biology, nuclear biochemistry, food, meteorology, inspection and quarantine, sports, tourism and other industries, and effectively evaluate social factors affecting residents’ health by relying on residents’ electronic health records and electronic medical record databases.Carry out biological monitoring of key infectious diseases, occupational diseases, imported infectious diseases at ports and medical vectors, integrate multi-source monitoring data of infectious diseases and occupational diseases, establish a rapid identification network system for laboratory pathogen detection results, and improve the ability to prevent and control major diseases. (The Provincial Health and Family Planning Commission is responsible for the cooperation of all members of the joint meeting of the provincial prevention and control of major diseases)
  (4) Promote the application of big data in traditional Chinese medicine. We will build a provincial platform for the management and utilization of big data resources of traditional Chinese medicine, a cloud platform for health information in TCM diagnosis and treatment areas, and a management information system for chronic diseases with TCM characteristics, health services and prevention of diseases. Improve and perfect the standards related to the analysis and application of big data of traditional Chinese medicine, build a big data center of traditional Chinese medicine and a database of diagnosis and treatment technology of traditional Chinese medicine covering medical treatment, prevention, health care, health preservation, rehabilitation, Chinese herbal pieces, Chinese patent medicines and hospital preparations, promote the application development of semantics of traditional Chinese medicine, data analysis and mining, intelligent diagnosis and treatment, knowledge management, vigorously develop "internet plus Traditional Chinese Medicine", realize diversified collection and in-depth analysis of big data resources of traditional Chinese medicine, and promote the convenience and benefit of smart Chinese medicine. Develop value-added services of TCM data resources and innovative services of TCM, and promote collaborative research on major diseases of TCM. (The Provincial Bureau of Traditional Chinese Medicine is responsible, with the cooperation of the Provincial Health and Family Planning Commission, the Development and Reform Commission, the Economic and Information Commission, the Science and Technology Department, the Civil Affairs Department, the Finance Department, the Culture Department and the Tourism Bureau)
  (5) Cultivate new formats for the application of big data in health care. Strengthen key technologies such as storage and cleaning of massive data in health care, analysis and mining, and security and privacy protection. Accelerate the integration and innovation of health care data and new generation information and communication technologies such as cloud computing and big data, promote the deep integration of health care business and big data technology, and accelerate the construction of health care big data industry chain. Actively encourage social forces to innovate and develop health care business, and take various measures to support the development of health care service industry. Develop home health information services, standardize services such as online pharmacies and third-party distribution of medical logistics, and continuously promote the coordinated development of health care and health care, pension, housekeeping and other service industries. Promote the development of Chinese medicine, health care, health management, health consultation, health culture, physical fitness, health medical tourism, healthy environment, healthy diet and other industries. (The Provincial Health and Family Planning Commission is responsible, with the cooperation of the Provincial Economic and Information Technology Commission, Science and Technology Department, Civil Affairs Department, Culture Department, Sports Bureau, Tourism Bureau and Chinese Medicine Bureau)
  (six) the development and promotion of digital health care intelligent equipment. Support the research and development of artificial intelligence technology, biological three-dimensional (3D) printing technology, medical robots, large-scale medical equipment, health and rehabilitation AIDS, wearable devices and related micro-sensor devices related to health care, accelerate the transformation of research and development results, improve the production and manufacturing level of digital medical equipment, Internet of Things equipment, smart health products, Chinese medicine functional status detection and health care instruments and equipment, and promote the upgrading of health care intelligent equipment industry. (The Provincial Economic and Information Technology Commission is responsible, with the cooperation of the Provincial Development and Reform Commission, the Health and Family Planning Commission, the Science and Technology Department, the Quality Supervision Bureau and the Bureau of Traditional Chinese Medicine)
  Fourth, standardize and promote the development of "internet plus Health Care"

  (a) the development of smart health care services for the convenience of the people. Integrate online and offline resources, and establish a "internet plus Health Care" service, payment and credit, health management and promotion system. Vigorously promote the application of Internet health consultation, online appointment and triage, mobile payment, intelligent guidance, whole process reminder and inspection results inquiry, follow-up, satisfaction feedback of medical industry and institutions, and form a standardized, shared, mutual trust and convenient health care service process. Develop third-party online health survey, consultation and evaluation, health management, health education and other application services to promote the quality of health care services. Promote the construction mode of new network hospitals such as online hospital, Pocket Hospital and Cloud Hospital, develop Internet hospitals, and promote online registration of birth. Based on residents’ electronic health records, integrate residents’ health management and medical information resources, and carry out electronic health information services covering the whole life cycle of prevention, treatment, rehabilitation and health management. Vigorously promote mobile payment of medical insurance, combine online service hall, mobile APP, WeChat and other means to carry out data integration and information sharing, expand the application of social security cards in the field of medical insurance, and realize medical services such as medical registration, inquiry of electronic medical records and health records, and direct settlement of medical expenses. Promote a healthy lifestyle, encourage residents to activate electronic health records, electronic medical records and other applications, and improve residents’ self-health management ability. (The Provincial Health and Family Planning Commission and the Human Resources and Social Security Department are responsible, and the Provincial Economic and Information Technology Commission and the Bureau of Traditional Chinese Medicine cooperate)
  (2) Establish a telemedicine application system in an all-round way.
  Build a telemedicine system connecting the third-class first-class hospitals and county hospitals in eastern, western and northern Guangdong. With county-level hospitals as the hub, a telemedicine network extending to township hospitals, community health service centers and conditional village health stations will be built, and the telemedicine coverage of various medical institutions at all levels will be gradually realized, and telemedicine services such as remote consultation, remote pathological diagnosis, imaging diagnosis, ECG diagnosis, monitoring guidance, surgical guidance and distance education will be carried out. Strengthen the connection of the province’s telemedicine network with other provinces, international academic institutions and well-known foreign medical institutions, and develop inter-provincial and international telemedicine. (Responsible for the Provincial Health and Family Planning Commission, with the cooperation of the Provincial Development and Reform Commission, the Economic and Information Commission, the Department of Finance and the Department of Human Resources and Social Security)
  Construction of regional pathology, imaging, ECG diagnosis center, further improve the mutual recognition mechanism of inspection results, and realize the interconnection and sharing of inspection results. Formulate telemedicine service prices, medical insurance payment policies and quality management systems to promote the normal operation of telemedicine systems. Promote data resource sharing and business collaboration between high-level hospitals and primary medical and health institutions, general practitioners and specialists. Open up the data channel between health management, disease treatment and rehabilitation, and accelerate the construction of a graded diagnosis and treatment information system based on the Internet and big data technology in accordance with the requirements of "first diagnosis at the grass-roots level, two-way referral, rapid division and treatment, and linkage from top to bottom". (The Provincial Health and Family Planning Commission and the Bureau of Traditional Chinese Medicine are responsible, and the Provincial Development and Reform Commission, the Economic and Information Commission, the Finance Department and the Human Resources and Social Security Department cooperate)
  (3) Promote the application of health care education and training. Relying on the national health care education and training network, explore the establishment of internet teaching mode and method, and build an open internet health care education system. Integrate online and offline high-quality online education resources, carry out health care popularization education for the public and carry out vocational continuing education for health care practitioners. Encourage higher-level hospitals to establish remote training networks with counterpart hospitals and graded diagnosis and treatment medical institutions, organize remote surgery teaching, and improve the ability of primary medical and health services. Explore the establishment of a general practitioner training model based on the Internet, expand the scale of general practitioner training, and ensure the quality of general practitioner training. Promote the open sharing of health care education resources. (Responsible for the Provincial Health and Family Planning Commission, with the cooperation of the Provincial Development and Reform Commission, the Economic and Information Commission, the Education Department, the Finance Department and the Bureau of Traditional Chinese Medicine)
  Fifth, improve the health care big data guarantee mechanism

  (1) Improve laws, regulations and standards. Establish a management system of "graded authorization, classified application and consistent powers and responsibilities", strengthen the standardized management of residents’ health information services, clarify the right to use information, and effectively protect the legitimate rights and interests of all parties. Formulate and improve data management, data and information system security and health data privacy protection systems, and clarify the boundaries, responsible subjects and specific requirements of data collection, transmission, storage, use and opening. Strengthen the protection of information related to national interests, public safety, personal privacy, population genes, etc., and prevent data abuse and privacy disclosure. Follow the national information standards and norms, establish a health care information standards and norms system, and promote the standardization of health care big data products and service processes. Strengthen the evaluation of standard application level and improve the standard application level. (Responsible for the Provincial Health and Family Planning Commission, with the cooperation of the Provincial Development and Reform Commission, the Economic and Information Commission, the Quality Supervision Bureau, the Legislative Affairs Office and the Bureau of Traditional Chinese Medicine)
  (2) Strengthen the security of health care data. Strengthen the classified management of health care data. The implementation of real-name registration system for residents’ health care services and the use of real-name management for health care data. We will build and improve a unified medical digital identity, electronic real-name authentication and data access control information system for medical and health workers and medical and health institutions in the province, actively promote the application of electronic signatures, and establish a health care data management model with traceable service management, safe operation of diagnosis and treatment data and multi-party cooperation. Adhere to both content security and technical security, and ensure that the regional national health information comprehensive management platform, data exchange network and key information systems are independently controllable, stable and safe. Carry out the reliability, controllability and security evaluation of big data platforms and service providers, as well as the security evaluation and risk assessment of applications, and establish software evaluation and security review systems such as security protection, system interconnection and sharing, and citizen privacy protection. Establish and improve the safety working mechanism of "internet plus Health Care" service, strengthen the safety monitoring and early warning of big data, strengthen the linkage between safety information notification and emergency response, improve the measures to resolve and respond to potential risks, strengthen the protection of important information involving national interests, public safety, patient privacy, business secrets and so on, and strengthen the information security protection of medical schools and scientific research institutions. Strengthen information security protection in cross-border exchanges and cooperation and cooperation between government and social capital. (The Provincial Health and Family Planning Commission is responsible, and the Provincial Development and Reform Commission, the Economic and Information Commission, the Public Security Department, the Human Resources and Social Security Department, the Intellectual Property Office and the Internet Information Office cooperate)
  (three) to strengthen the construction of health care information compound talent team. Taking "digital doctors" as the training goal, we will formulate the development plan of health care informatization talents and strengthen the discipline construction of medical informatics. Establish and improve the training system of medical informatics talents, focus on cultivating high-level and compound medical information R&D talents and scientific research teams, and cultivate a group of internationally influential medical professionals, academic leaders and industry leaders. Encourage and support institutions of higher learning, health care institutions, industry associations and health care information enterprises to establish educational practice and training bases, closely follow the development needs of the health care big data industry, carry out continuing education and training, and promote the training and team building of health care big data talents. Smooth the career development channel of medical information talents and expand the development space of medical information talents. Orderly promote talent and technology exchanges and cooperation in the development of big data application in health care. (The Provincial Health and Family Planning Commission is responsible, and the Provincial Development and Reform Commission, the Economic and Information Commission, the Education Department, the Finance Department and the Human Resources and Social Security Department cooperate)
  Sixth, strengthen the organization and implementation

  (1) Strengthen overall coordination. All localities should establish a working pattern of government leadership, multi-party participation, resource sharing and coordinated promotion. According to the requirements of this implementation opinion, they should put forward the implementation plan of their own regions, clarify specific tasks, and ensure that all measures are implemented. The evaluation results such as the construction of comprehensive management platform for national health information, the maturity of interconnection, the quality of health care data, and the application level of electronic medical records in medical institutions are included in the evaluation of deepening the reform of medical and health system in the province and the evaluation of strong health cities. The Provincial Health and Family Planning Commission should take the lead in establishing a joint conference system to promote and standardize the application and development of big data in health care, strengthen the overall coordination of research and development, new format construction and application promotion of big data technology in health care in the province, and promote the implementation of key tasks. All relevant units should closely cooperate and form a joint force to strengthen support for the development of big data applications in health care. Promote the integrated development of military and civilian health care big data, and promote the standardization, interoperability and collaborative application of military and local health care data. (The municipal people’s government and the provincial health and family planning commission are responsible for all localities, and all relevant units cooperate)
  (2) Focus on key breakthroughs. All localities should focus on solving the problem of big data application infrastructure construction, accelerate the construction of a comprehensive management platform for national health information at the city and county levels, and accelerate the progress of information system transformation and upgrading of medical and health institutions. Starting from the areas urgently needed by the masses, we will implement the health care big data demonstration project, focusing on promoting the application of big data such as health care, industry governance, clinical medical care and scientific research, public health and traditional Chinese medicine in internet plus. Vigorously support the introduction, digestion, absorption and re-innovation of advanced technologies of health care big data, and focus on developing the health care big data industry chain. Select a number of areas and fields with good basic conditions, high work enthusiasm and guaranteed privacy and security to carry out the pilot application of big data in health care, sum up experience in a timely manner, and make solid and orderly progress. (The Provincial Health and Family Planning Commission and the Finance Department are responsible, and the Provincial Development and Reform Commission, the Economic and Information Commission and the Science and Technology Department cooperate)
  (3) Increase policy support. Promote the use of government and social capital cooperation (PPP) model to encourage and guide social capital to participate in the infrastructure construction, application development, operation and maintenance services and industrial chain construction of health care big data. Encourage medical and health institutions to cooperate with enterprises, institutions and social institutions, and explore ways to achieve the integration of government applications and social applications in the field of health care big data through government procurement and social crowdsourcing. Encourage innovative diversified investment mechanisms, improve risk prevention and supervision systems, and support the development of health care big data applications. Support qualified health care big data enterprises to go public for financing or issue corporate bonds, connect with multi-level capital markets, and use various financing tools for financing. (The Provincial Health and Family Planning Commission and the Finance Department are responsible, and the Provincial Development and Reform Commission, the Economic and Information Commission, the Science and Technology Department, the Finance Office and the Guangdong Securities Regulatory Bureau cooperate)
  (4) Strengthen policy propaganda. Strengthen the interpretation of health care big data application development policies, vigorously publicize the significance and application prospects of application development, actively respond to social concerns, and form a good social atmosphere. Actively guide medical and health institutions and social forces to carry out various forms of popular science activities, publicize and popularize the application knowledge of big data in health care, and continuously improve the people’s ability to master relevant applications and health literacy. (The Provincial Health and Family Planning Commission is responsible and all relevant units cooperate)

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General Office of Guangdong Provincial People’s Government

February 8, 2017

Hollywood’s "Big Five" in 2023: Which movies lost money and which ones sold well?

North America is the largest film market in the world, and it is also the main battlefield to test the success or failure of a Hollywood film. Generally speaking, there are two institutions that regularly publish box office data of North American film market: the website Box Office Mojo mainly collects and counts the data reported by publishers themselves; Comscore, a media company specializing in collecting and analyzing all kinds of data, collects daily box office data from the cinema, which is also the main source of box office data for American media.

Traditionally, Comscore’s annual report will not be released until the first Tuesday of the new year, that is, January 2, 2024, local time in the United States, but it is said that the total box office in North America will basically fall between $9.03 billion and $9.05 billion in 2023. As for Box Office Mojo, because of the time difference, the North American box office figure in 2023 on this website is still at $8.905499 billion for the time being, but I believe it will be further updated in a few days.

"Baben Harmo"

Looking back on the key words of North American movies in 2023, the first one was "Baben Harmo": two commercial blockbusters with irrelevant contents and types collided head-on in the same schedule, and the result was not that they changed, but that they successfully ignited the audience’s enthusiasm together and became a phenomenal movie event in 2023. Barbie, produced by Warner Bros. Film Company, finally became the North American box office champion in 2023 with a score of $636 million, while Oppenheimer, produced by Universal Pictures, ranked fifth in the annual box office list in North America with $326 million.

The success of the two works has its own reasons, but to sum up, it is nothing more than abandoning the routine and highlighting the new ideas. Together with Universal Pictures’ Super Mario Bros. Movie, which ranked second in North America’s annual box office list with US$ 574 million, these three works can be said to have high original value.

Although Barbie comes from a world-famous popular toy, Super Mario Bros. Movie is based on a well-known video game of the same name, and the protagonist of Oppenheimer has already gone down in history because of the atomic bomb, they are not actually sequel to the movie or remakes of old movies, which can attract the audience to buy tickets and rely on real original stories and designs.

Stills of Super Mario Bros. Movie

In sharp contrast, in 2023, a lot of blockbusters failed at the box office, almost all sequels and series of works. In addition to the superhero movies that have completely tired the audience aesthetically, Raiders of the Lost Ark 5 and Mission Impossible 7 have also failed to achieve satisfactory box office results.

The total box office in North America in 2023 is definitely the highest in North America since the epidemic subverted the film industry, far better than the $7.46 billion in 2022 and $4.56 billion in 2021. However, such achievements have not returned to the level before the epidemic.

Historically, the box office in North America has steadily exceeded $10 billion every year since 2009, and since 2015, this figure has exceeded $11 billion every year. Before the epidemic, in 2019, although the box office performance of North American movies has been severely squeezed by the streaming media market, the box office of the whole year can still easily reach 11.4 billion US dollars.

On the surface, it seems that the main reason is that the number of films released by Hollywood studios is getting smaller and smaller every year: only 88 films were released on a large scale in 2023, while in 2019, the box office reached 10.5 billion US dollars, which was 108, a full 20 more. However, I really want to say, even if there are 20 more new films in 2023, will it be guaranteed that the box office will increase by 2 billion US dollars? Who can say that these 20 films will get an average of $100 million at the North American box office each?

Movies like Barbie and Oppenheimer can persuade people to pay for tickets because they can only appreciate the beauty of light and shadow when they are watched on the big screen, and the same is true for Taylor Swift: Time Tour Concert, which became a dark horse at the box office near the end of the year. In 2023, when the streaming media service is becoming more and more mature (and saturated), how many movies must be experienced in the cinema in the eyes of the audience? Below, we will look at it according to the winners and losers list of the five major Hollywood manufacturers.

Universal Pictures International

Wins: Super Mario Bros. Movie ($575 million), Oppenheimer ($326 million), Five Nights of the Teddy Bear ($137 million) and Megan ($95 million).

Negative: Speed and Fury 10 ($146 million), Renfield ($17 million), Demeter’s Last Voyage ($13 million).

According to film companies, Universal Pictures, which won $1.93 billion in 2023, topped the North American box office list. With the blockbuster films such as Super Mario Bros. Movie and Oppenheimer, Universal has occupied about 22% of the box office share in North America, slightly overwhelming Disney and winning the first prize since 2015.

Oppenheimer stills

In 2023, Universal occupied two seats in the top five most popular films in North America. In addition, the innovative thriller Megan, which cost only $12 million, also earned nearly $100 million at the box office, while Five Nights of the Teddy Bear turned the cost of $20 million into a box office of $137 million, making them the two most cost-effective movies in 2023.

Of course, Universal also made some mistakes in 2023, and the tenth The Fast and the Furious series was exhausted, but the production cost was getting higher and higher, reaching a shocking $340 million, which erased a lot of the annual bonus of Universal.

In 2024, Kung fu panda 4’s "Daddy Thief 4" and other works will be listed around the world, and there is still a chance to win the championship again.

Disney

Wins: Galaxy Guard 3 ($359 million), The Little Mermaid ($297 million), Crazy Element City ($154 million).

Negative: Captain Surprise 2 ($84 million), Indiana Jones 5 ($174 million), Star Wish ($61 million), Haunted House ($68 million).

2023 is Disney’s centenary birthday, which should have been a year worth celebrating. Various commemorative movies, books and activities were also arranged in advance. However, the overall commercial achievements released at the end of the year made 2023 a year when Mickey Mouse fell to the altar.

Since the annual box office accounted for 26% in 2016, Disney has become the sole overlord of Hollywood in the past few years by relying on its fist products such as Marvel Comics and Pixar; The peak appeared in 2019, accounting for 33.3% of the box office. Seven of the top ten films in the world were produced by Disney, and the box office of each film exceeded $1 billion, leaving the other Hollywood giants completely behind.

However, with the arrival of COVID-19, everything came to an abrupt end. Three years after the epidemic, Disney’s box office share was only 11%, 20% and 18% respectively. However, at that time, Disney’s box office declined because of the external factors of closed cinemas and filming stoppage, which can be said to be a crime of no war. By the end of the epidemic in 2023, Disney’s box office still accounts for only 16%, so you can only find the reason from yourself.

The most serious problem is naturally the continuous downturn of the Marvel movie universe. From "Ant Man 3" at the beginning of the year to "Captain Surprise 2" at the end of the year, all of them lost their eye-catching characteristics in the past, and the latter even became the worst box office in the history of Marvel Comics movies, which made Disney CEO Bob Iger admit that at the previous stage, they really made a big mistake of focusing only on quantity and ignoring quality. At the same time, it also reminds opponents once again that there has never been any panacea in Hollywood, and the tastes of the audience are changing rapidly. Sitting on one’s laurels and standing still is doomed to die.

"Galaxy Guard 3" poster

On the whole, among the top ten box offices in North America, Disney still has the illusion that "Guards of the Galaxy 3" ranks fourth, "The Little Mermaid" ranks sixth and "Ant Man 3" ranks eighth, and there is still the illusion that "the skinny camel is bigger than the horse". However, excluding the special circumstances of the epidemic for three years, this has become the first year since 2014 that Disney has not had any film with a global box office exceeding the $1 billion mark.

Of course, Disney’s advantage is that it has acquired a large number of high-quality assets through mergers in the past few years. After being acquired by Disney, 20th Century Fox, which originally belonged to the ranks of the six Hollywood manufacturers, was renamed 20th Century Pictures, and its box office was also included in the Disney Group’s evaluation. In 2023, they released three works, Cabinet Devil, Venetian fright night and AI Creator. Together with the release of Avatar 2 in early 2023, they earned about $400 million in North American box office. Including this part, Disney accounted for about 21% of the annual box office in North America, ranking second.

Warner Bros.

Wins: Barbie ($636 million), Nun 2 ($86 million), Meg 2 ($82 million), Wonka ($143 million).

Negative: The Flash ($108 million), The Blue Beetle ($72 million), Shazam 2 ($57 million), Aquaman 2 ($85 million).

With Barbie, the highest box office in North America in 2023 (the film also won the annual global box office champion with a box office score of $1.44 billion), Warner failed to become the North American box office champion in 2023, ranking third with only $1.4 billion and a share of about 15.24%. I am afraid that the reason can only be attributed to the poor box office performance of DC superheroes.

"Barbie" stills

In addition to Barbie, in 2023, Warner also tasted a lot of sweetness in the horror film Sister 2 and the family movie Wonka. However, they invested about $660 million in the production cost of the four DC films, The Flash, The Blue Beetle, Shazam 2 and Aquaman 2. As a result, the global box office revenue of the four films was less than that of the 2016 Batman v Superman: Dawn of Justice ($874 million).

In 2024, Warner will publish Dune 2, Godzilla vs. king kong 2, Clown 2 and other works, which hopefully will lead to a comeback.

Sony pictures

Wins: Spider-Man: The Vertical and Horizontal Universe (US$ 381 million) and The Wronger 3 (US$ 92 million).

Negative: Silly Money ($13 million) and Escape from Cretaceous ($32 million).

In 2020, when the world was in chaos, Sony Pictures once became the biggest winner in the North American film market, gaining more than 20% market share. After that, in 2021, they also continued to be in the forefront. However, in 2022, when everything is slightly back on track, Sony’s market share has retreated to the fifth place. In 2023, the situation is slightly better than that of Paramount, which is at the bottom. The annual box office of less than $1 billion accounts for about 11% of the market.

Stills of Spider-Man: The Vertical and Horizontal Universe

During the three years of the epidemic, Sony released about 16 or 17 works every year, and in 2023, it rose to 27, far more than any other Hollywood factory, and basically recovered to the level before the epidemic.

The animated film Spider-Man: The Vertical and Horizontal Universe, which was released in June, is a rare Marvel Comics movie that sold well at the box office in 2023. The global box office of "Grievance 3" also reached $190 million, almost the same as the first two films, showing the high popularity of Denzel Hayes Washington Jr.. As for "Napoleon" released at the end of the year, it is not a box office success in itself. After all, the production cost of the film is as high as 200 million US dollars. However, this huge sum of money basically comes from Apple with deep pockets, and Sony is only responsible for issuing, and the package will not be compensated.

In 2024, as usual, Sony will have a wave of new films such as Ghostbusters: The Frozen City, Garfield, Mrs. Spider: Super Awakening, Kraven the Hunter, Venom 3, etc., and the box office should make a breakthrough.

Paramount

Wins: Scream 6 ($108 million), Wang Wang Team 2 ($65 million), Teenage Ninja Turtles: Mutant Fight ($118 million).

Negative: Mission Impossible 7 ($172 million) and Dungeons and Dragons: The Glory of Grand Theft Auto ($93 million).

2023 is really a year to break the Hollywood convention. Not only has the invincible superhero movies been beaten, but even Tom Cruise, which has always been a box office guarantee, has experienced the existential crisis of Lian Po’s old age.

Before the release of "Mission Impossible 7", almost everyone expected that it would be Tom Cruise’s second successful summer file after "Top Gun 2". As a result, "Mission Impossible 7" failed to ignite the enthusiasm of North American people for watching movies on the first weekend, and was quickly defeated by Barbie and Oppenheimer. The most deadly thing is that the epidemic pushed the production cost of the film up to an astonishing $291 million, which caused it to bear an excessive burden before it was released.

Dungeons and Dragons: Glory of Grand Theft Auto poster

The box office failure of Dungeons and Dragons was also somewhat unexpected. After all, the film was adapted from a powerful game IP, and the audience’s reputation after the screening was very good, but perhaps because of the schedule, there was still a lack of enough audience to join in, which made this $150 million film unable to break even.

In the whole year, Paramount released a total of 10 films, with a box office of just over $800 million, accounting for about 9.6% of the total box office in North America, ranking fifth, far below the market share of 17.6% in 2022 with the blessing of Top Gun 2.

In 2024, Paramount will release some blockbuster new films, such as Gladiator 2, Transformers: The First Generation and Sonik the Hedgehog 3, which is expected to turn the tide.

Taylor Swift: Time Tour Concert Poster

In addition to the above-mentioned five Hollywood giants, Lionsgate Pictures, which took 6.55% of the market share, ranked sixth in the annual box office in North America. They released 12 films in the whole year, and "Fast Chasing 4" ranked ninth in the annual single box office in North America with $187 million. Further back, the independent film "Voice of Freedom", which is not unusual in shooting, distribution and publicity, won $184 million at the box office, which just squeezed into the tenth place in the annual single-chip box office list in North America.

Taylor Swift: Time Tour Concert, with the same maverick distribution model, earned $179 million at the box office, ranking 11th in the annual single-chip box office list in North America. Independent films like this broke into the top of the annual box office list for more than ten years, which seems to reflect the coming of the unprecedented changes in Hollywood in N years.

Global central banks continue to buy gold, and the fluctuation of gold price does not hinder the medium and long-term upward trend.

  Our reporter Gu Mengxuan Xia Xin reports from Guangzhou and Beijing. 

  Recently, the international gold price hit a record high and was quickly sold off, causing a sharp drop. The price of gold denominated in RMB has also fluctuated greatly, which has aroused widespread concern in the market. 

  On December 4th, the price of gold futures in new york market once rushed to the $2,150 mark per ounce, with an intraday increase of over 3%, setting a record high. Subsequently, the price of gold quickly fell back, and as of the 7 th, the cumulative correction per ounce exceeded $100. 

  Affected by this, the gold Au99.99 listed on the Shanghai Gold Exchange fell back after it surged to 487 yuan per gram on the 4th, and the retail price of some domestic brands of gold jewelry stood at the high level of 630 yuan per gram and then fell back to about 615 yuan per gram on the 7th. 

  According to Wind data, on December 15th, the New York Mercantile Exchange gold futures price was reported at 2018.3 USD/oz; As of press time, the gold Au99.99 listed on the Shanghai Gold Exchange is 472.99 yuan per gram. 

  Welcome to a loose inflection point 

  Regarding the correction of gold price, Wang Xiang, fund manager of Bosera Fund Index and Quantitative Investment Department, pointed out that the Fed’s interest rate hike cycle tends to end, which will usher in a loose turning point. Gold benefits from the downward logic of liquidity easing and real interest rate. Historically, similar policy nodes have strong price support power. However, there is a profit-taking impulse near the historical high point, and the net long position of short-term COMEX futures fund is too fast, so there is a need for adjustment. 

  At 3: 00 am on December 14th, Beijing time, the Federal Reserve issued the statement of the FOMC meeting in December 2023 (the Federal Reserve’s meeting on interest rates), and once again announced the suspension of interest rate hikes. 

  According to the data provided by Bosera Fund, inflation expectations in the United States have dropped significantly. In December, the consumer confidence index of the University of Michigan rose to 69.4, with an expectation of 62. The inflation expectation dropped significantly, with the one-year inflation expectation dropping from 4.5% to 3.1% and the five-to ten-year inflation expectation dropping from 3.2% to 2.8%. "This combination is not good for precious metals." Wang Xiang said. 

  As for the rise in the price of gold in the early stage, Bi Mengyu, an investment researcher at Geshang Caifu Jinyu, pointed out that gold, as a non-interest-bearing physical asset, often ushered in rising opportunities when other assets had poor returns. 

  First of all, from an economic point of view, the global economy is currently in recession. In view of the worries about the economic downturn and the stock market decline, driven by risk aversion, investors are more willing to buy gold to avoid risks, leading to the rise of gold prices. In November, the global manufacturing PMI (Purchasing Managers Index) was 49.3, the US manufacturing PMI was 46.7, and the Eurozone manufacturing PMI was 44.3, all of which were below threshold, reflecting the overall global economic downturn. 

  Secondly, last week, the ADP data in the United States (an economic indicator commonly used to measure the job market) failed to meet expectations. The market speculated that the Federal Reserve would not raise interest rates in December, that is, the nominal interest rate showed a downward trend with a high probability, which made the price of gold rise again. 

  Finally, global central banks continue to purchase gold, and the demand for gold purchase by global central banks will remain strong in 2023, which supports the upward trend of the overall price of gold. 

  "The adjustment of gold this week was mainly due to the rising interest rate of the US dollar index and US debt after the US non-farm payrolls data exceeded expectations, and coupled with the’ hawkish’ signal released by the Federal Reserve Chairman, the price of gold fluctuated downward." Bi Mengyu said. 

  The annualized compound yield of gold is 7% 

  The reporter noted that in August this year, the trend of domestic and international gold prices deviated greatly. In recent months, has the excessive price difference between the internal and external markets of gold prices been corrected? 

  Wang Xiang pointed out that in September this year, the price difference between domestic and foreign countries was the highest, 30 yuan+/gram, and at present, the price difference has largely converged to 7 yuan/gram, but it is still far from the historical 95% confidence fluctuation range of 1.2~1.8 yuan/gram. In the process of convergence, the performance of domestic gold price will be worse than that of dollar gold. 

  Bi Mengxuan pointed out that the international gold price and the domestic gold price are basically in a positive correlation, but due to the influence of pricing system, rate and time lag, they may deviate in the short term, and the domestic gold price fluctuation is often lagging behind. After several months of adjustment, the international and domestic gold prices have basically converged. 

  Central banks around the world have also shown sustained enthusiasm for buying gold. According to the data of the World Gold Council, in 2023, the global central bank’s demand for gold purchases remained strong, reaching 387 tons in the first half of the year, a record high in the same period; In the first three quarters, the amount of gold purchased reached a record 800 tons, a year-on-year increase of 14%. At the same time, the data released by the State Administration of Foreign Exchange showed that at the end of November, the gold of the Bank of China had increased for the 13th consecutive month. 

  In this regard, Bi Mengyu pointed out that the central bank’s allocation of gold mainly considers security, liquidity and return. First of all, gold is regarded as a safe asset and a value-preserving asset by the central bank, because it is more stable in the face of credit risks than other assets such as national debt; Secondly, gold has strong liquidity, and the central bank can quickly enter the market without distorting the price; Finally, although the return is not the main motivation for the central bank to buy gold, the annualized compound rate of return of gold has been around 7% in the past few decades, providing investors with relatively considerable returns. 

  "The proportion of gold in China’s foreign exchange reserves is still low. Although it has been continuously increased, the current proportion is still less than 6%, which is still far from the proportion of more than 40% in European and American countries." Wang Xiang said that increasing the proportion of gold in foreign exchange reserves will help to diversify the reserve structure and maintain the stability of local currency and asset prices during the contraction cycle of the US dollar. 

  Rational investment by investors 

  Regarding the future market of gold assets, Nuoan Fund pointed out that due to the issuance of bonds by the US Treasury, the reduction of US debt holdings by the Federal Reserve and the current strong economic expectations, it is expected that the long-term yield of US debt will remain high, and short-term gold will still be suppressed by interest rates and the US dollar index. However, we expect that the signs of economic slowdown in the United States may be more obvious in the first half of 2024, and high interest rates and recent geopolitical risks may increase the volatility of financial markets compared with the previous period. The logic of gold investment gradually shifts from short-term safe-haven demand to medium-and long-term Fed interest rate cuts. Recently, the market expects the Fed to cut interest rates, which has significantly boosted the price of gold, or it is expected to change more by pricing. It is suggested that investors should actively pay attention to the trend of gold price and consider the proportion of gold allocation to grasp the investment opportunity of gold. 

  Wang Xiang said that whether inflation converges smoothly, leading European and American monetary policies to shift to liquidity logic, or inflation rises again due to unexpected events, taking stagflation logic, different macro paths are beneficial to the gold margin, making it still one of the assets with high certainty, and the only difference is the difference in odds. Next year is an election year for many economies, and the intensity of geo-game may remain at a high level, which is also conducive to the rise of the price center. The upward target of USD gold is USD 2,200 ~ 2,400, which is about 515~550 yuan/g in China. 

  "It is normal for the regional fluctuation of gold prices to increase near historical highs. Investors should neither be overly enthusiastic in the overbought state of the market, nor completely lose confidence after their breakthrough failure." Wang Xiang pointed out that in the medium and long term, the easing of the Federal Reserve and the weakening of the US dollar will remain a high probability path next year. With many economies entering the election year, the intensity of geo-game will remain at a high level. After the short-term selling sentiment is released, gold will return to its long-term upward path again.

Eight departments prevent and control teenagers’ myopia: regulate the total amount of online games, and ban mobile phones in class.

  BEIJING, Beijing, August 31 (Xinhua) On the 30th, the "Implementation Plan for Comprehensive Prevention and Control of Myopia among Children and Adolescents" formulated by the Ministry of Education and National Health Commission was announced. For example, ensure that primary school students sleep for 10 hours every day, prohibit students from bringing electronic products such as mobile phones into the classroom, and control the number of new online games. The plan lists a series of hard measures to "protect their eyes" for children and adolescents.

  — — By 2030, the myopia rate of high school students will drop below 70%

  The plan proposes that by 2023, we will strive to reduce the overall myopia rate of children and adolescents nationwide by more than 0.5 percentage points per year on the basis of 2018, and the provinces with high incidence of myopia will reduce by more than 1 percentage point per year.

  By 2030, the rate of new-onset myopia among children and adolescents in China will be significantly reduced, and the overall level of children and adolescents’ visual health will be significantly improved. The myopia rate of 6-year-old children will be controlled at around 3%, the myopia rate of primary school students will be reduced to below 38%, the myopia rate of junior high school students will be reduced to below 60%, the myopia rate of senior high school students will be reduced to below 70%, and the excellent rate of national students’ physical health standards will be over 25%.

  [family]

  — — Children are exposed to outdoor natural light for more than 60 minutes every day at home.

  The plan requires that a good family sports atmosphere should be created, and children should be actively guided to engage in outdoor activities or physical exercise, so that they can be exposed to outdoor natural light for more than 60 minutes every day at home.

  Encourage and support children to participate in various forms of sports activities, urge children to conscientiously complete sports homework in winter and summer vacations, enable them to master 1-2 sports skills, and guide children to develop lifelong exercise habits.

  — — The cumulative use of electronic products for non-learning purposes should not exceed 1 hour per day.

  The plan reminds parents to control the use of electronic products, and consciously control their children, especially preschool children, to use electronic products. The single use of electronic products for non-learning purposes should not exceed 15 minutes, and the cumulative time should not exceed 1 hour every day. After studying with electronic products for 30-40 minutes, they should take a rest and relax for 10 minutes. The younger they are, the shorter the continuous use of electronic products should be.

  — — Ensure that primary school students sleep for 10 hours every day.

  The plan requires that parents should supervise and correct their children’s bad reading and writing posture at any time, and the continuous eye use time for reading and writing should not exceed 40 minutes.

  Parents should cooperate with the school to effectively reduce the burden on their children. Don’t blindly participate in extracurricular training and follow the trend. They should make reasonable choices according to their hobbies to avoid reducing the burden on schools and families.

  Guarantee children’s sleep time, and ensure that primary school students sleep 10 hours a day, junior high school students 9 hours, and senior high school students 8 hours.

  — — Not assigning homework in the first and second grades of primary school should not make students’ homework become parents’ homework.

  The plan requires that schools should reduce students’ academic burden. There is no written homework for the first and second grades of primary school, and the completion time of written homework for the third to sixth grades should not exceed 60 minutes, and it should not exceed 90 minutes for junior high school. The homework time should also be reasonably arranged for senior high school. Strengthen practical homework, reduce mechanical and repetitive training, and prevent students’ homework from evolving into parents’ homework.

  — — Grade one and grade two exams shall not exceed once per semester, and other grades shall not exceed twice.

  The plan stipulates that the number of unified examinations in the compulsory education stage should be resolutely controlled. The first and second grades of primary school should not exceed once per semester, and other grades should not exceed twice per semester. It is strictly forbidden to publish students’ test scores and rankings in any form or manner; It is strictly forbidden to use the award-winning certificates of various competitions, academic competition results or grading certificates as the basis for enrollment; It is strictly forbidden to organize examinations to select students in various names.

  — — Adjust the seat every month according to the change of students’ vision, and adjust the seat height every semester.

  The plan requires that the phenomenon of "large class size" be eliminated quickly. The compliance rate of school classroom lighting hygiene standards is 100%. According to the viewing angle of students’ seats, the lighting situation in the classroom and the changes of students’ eyesight, the students’ seats are adjusted every month, and the height of students’ desks and chairs is adjusted individually every semester to adapt to the growth and development of students.

  According to the plan, ensure that primary and secondary school students have more than one hour of physical activity time every day at school. Strictly implement the national physical education and health curriculum standards, and ensure that the first and second grades of primary school have 4 class hours per week, the third to sixth grades and junior high school have 3 class hours per week, and the senior high school has 2 class hours per week. Primary and secondary schools arrange 30 minutes of big recess sports activities every day.

  — — Students are strictly forbidden to bring electronic products such as mobile phones and tablets into the classroom.

  According to the plan, schools should prohibit students from bringing personal mobile phones, tablets and other electronic products into the classroom, and those brought into the school should be kept in a unified way. In school education, electronic products are used reasonably according to the principle of demand, and teaching and assignment are not dependent on electronic products. In principle, the teaching time using electronic products should not exceed 30% of the total teaching time, and paper homework should be used in principle.

  — — Textbooks, test papers and other font papers should protect their eyesight and push mandatory standards before the end of next year.

  According to the plan, before the end of 2019, National Health Commission will, together with relevant departments, issue relevant mandatory standards to strictly regulate the fonts and papers of textbooks, teaching AIDS, examination papers, exercise books, newspapers and other printed materials and publications for children and adolescents, as well as study lamps, so as to protect their eyesight.

  — — Regulating the total amount of online games and controlling the number of online games newly added.

  According to the plan, the State Press and Publication Administration should regulate the total number of online games, control the number of new online games, explore an age-appropriate reminder system in line with national conditions, and take measures to limit the use time of minors.

  In addition, the State Administration of Market Supervision should strictly supervise the optometry and glasses industry, standardize the glasses market, and prevent unqualified glasses from entering the market. Strengthen advertising supervision and investigate and deal with false and illegal advertisements for myopia prevention and control products according to law.

  — — Prevention and control of myopia, overall myopia rate and physical health are included in the government performance appraisal.

  According to the plan, the State Council authorized the Ministry of Education, the National Health and Wellness Commission and the provincial people’s governments to sign responsibility letters for comprehensively strengthening the prevention and control of myopia among children and adolescents, and local people’s governments at all levels signed responsibility letters step by step. The prevention and control of myopia in children and adolescents, the overall myopia rate and physical health status will be included in the government performance appraisal.

  Incorporate vision health into quality education, incorporate children’s physical and mental health and schoolwork burden into the national compulsory education quality monitoring and evaluation system, and hold local governments and schools accountable according to laws and regulations for the decline of children’s physical health for three consecutive years.

Eating self-heating hot pot triggers an alarm! Even after eating, it may explode?

  CCTV News recently reported on the safety investigation of self-heating hot pot.

  You don’t need fire or electricity, just add a bottle of water, and you can enjoy the hot pot … … Nowadays, the so-called "lazy people cook their own hot pot" has quietly become popular, and some brands have also introduced self-heating foods such as rice, noodles and vermicelli. However, in the investigation, the reporter found that although the self-heating convenient hot pot is delicious and fast, there are certain safety hazards. The heating package of self-heating food is flammable and explosive, so consumers should be very careful when using it, and it is not allowed to take it by train or plane.

  What is a self-heating hotpot?

  Self-heating hot pot does not need fire or plug in electricity, and it is mainly composed of ingredients, an ingredient pot, a pot cover, an outer pot and a heating bag. The heating principle is to use the substance in the heating bag to contact with water to release heat, so that the temperature of the food in the upper food pot increases after absorbing heat. Besides self-heating chafing dish, it is also called micro chafing dish, clear boiled chafing dish and self-cooking chafing dish.

  This product, which first appeared in Wechat business’s circle of friends, attracted more and more catering and food companies to join. From making hot pot bottom materials to chain hot pot restaurants, many companies have started self-heating small hot pot business. Even a good shop that makes snacks sells self-heating hot pot in its own Tmall flagship store. Now go to e-commerce platforms such as Tmall and JD.COM to search for "self-heating hot pot", and at least nearly 30 brands will appear.

  Eat a hot pot and call the police!

  However, there is no small safety risk in this convenient hot food. The reporter noticed that there are many reports on the Internet that the alarm will give an alarm when the self-heating hot pot is used, and consumers have sent the video that triggered the continuous alarm of the gas alarm when using the self-heating hot pot to the short video platform.

  Consumer Xiao Chen has been afraid to eat self-heating hot pot at home since it caused the gas alarm to call the police. According to reports, she was operating in the kitchen according to the instructions. After the lid began to steam, she planned to go back to the house for a while, but before she left the kitchen, the gas alarm suddenly rang.

  "At that time, I was shocked. I was afraid of gas leakage and specially called the gas company. The other party said that the gas did not leak after the door-to-door inspection." The inspectors said that it may be caused by the self-heating chafing dish, because the gas alarm will only give an alarm when it detects that carbon monoxide exceeds the standard, which may be caused by the gas released when the self-heating chafing dish is heated.

  In addition, consumer Xiao Li told reporters that once he ate self-heating rice on the glass coffee table at home, the vent hole on the lid of the box just burst, and he heard a bang, and the corner of the glass coffee table burst, causing the rice to spill all over the floor.

  The reporter bought a box of self-heating hot pot at random. After unpacking, first put the hot pot bottom and all the ingredients into the lunch box and add cold water. Then tear off the outer bag of the heating package and put it in the bottom box, and add cold water without heating the package. Place the food box on the heating bag, open the vent hole on the closed cover and cover the hot pot tightly. After a few seconds, steam will be ejected from the vent hole. After a few minutes, the sound of boiling water will be heard in the box, and the box will expand and deform when heated, and the high temperature can be felt near the lunch box. After more than 10 minutes, the box gave out a bang, and then the gas alarm at the reporter’s home rang. Turn off the gas alarm and wait for a few minutes, open the airtight cover, and high-temperature steam will blow on my face. In the process of eating, the self-heating hot pot has always maintained a high temperature. After eating for an hour, the outside of the lunch box still feels hot.

  The manufacturer said this.

  Why does the alarm continue to alarm?

  So, what is the reason that causes the gas alarm to alarm continuously? The reporter dialed the telephone number of the manufacturer of the heating package. "When the heating package heats up, it will produce a small amount of hydrogen, because hydrogen will cause the smoke sensor to alarm." The person in charge of a heating package manufacturer said. Hydrogen is a combustible and reducing gas. Pure hydrogen burns quietly in the air, while impure hydrogen may explode when it burns.

  Is it dangerous to generate hydrogen in the heating package?

  However, in view of the hydrogen generated during the reaction of the heating package, the personnel of the manufacturer claimed to the reporter that "there is absolutely no safety hazard".

  The person in charge of a heating package manufacturer told the reporter: "It doesn’t matter. If that thing is dangerous, it can’t be so hot in the market. Don’t think it’s so dangerous, it’s not so dangerous, and big companies are doing it."

  safety test

  1 In a confined space, the heating package has the risk of deflagration.

  The manufacturer of the heating package said that there was absolutely no potential safety hazard. However, reports about the alarm of the self-heating food appeared from time to time. Then, is there a safety hazard after the heating package reacts with water?

  Not long ago, the Shanghai Consumer Protection Committee informed about the testing of 20 self-heating instant hot pot products. The test items include the inspection of appearance and packaging label, the surface temperature of the pot, the gas released by the heating package when it meets water, the secondary water addition reaction of the heating package, the composition and content of the heating package and other indicators. The test results show that all the tested heating packages belong to "substances or mixtures that emit flammable gases when in contact with water".

  Shang Zhaocong, executive deputy director of the National Chemical Product Safety Quality Inspection Center, told the reporter: "We have done a lot of experiments, and basically each heating package can generate about 40 liters of hydrogen. The combustion limit of hydrogen in air is 4% to 75.6%. Of course, there are other closed or semi-closed conditions, such as inside the car, which will have similar risks. "

  You should also be careful when eating hot pot together on the tourist bus.

  Not only the self-heating food may bring the risk of deflagration when it is used in a closed space, but also it has great safety hazards when it is used intensively in some public places.

  Xiao Qiuping, assistant director of the National Chemical Products Safety Quality Inspection Center, said: "For example, many tourists don’t know that hydrogen will be generated during the driving of tourist buses and long-distance buses. The large-scale use of self-heating hot pot may lead to the accumulation of hydrogen in vehicles, especially in summer, when the air conditioner is turned on, and the whole compartment is in a closed environment. In this case, if the lower explosion limit concentration is reached and a little fire source is encountered, a lighter is not needed.

  3 After using the discarded heating package, there are still potential safety hazards.

  Experts also told reporters that not only the self-heating products may bring the risk of deflagration after reaching the deflagration limit value of hydrogen in the use process, but also there are safety hazards after using the discarded heating packages.

  In this experiment, the Shanghai Consumer Protection Committee also submerged 20 sample heating packages in water again. The results show that there are 14 samples of heating packs with different degrees of continuous deflation. The reaction duration is more than 3 minutes, and the longest is 8 minutes.

  If such a heating package is discarded and meets water in a closed space such as a garbage can, and a little fire source is added, it may burn.

  Safety warning to be standardized, safety standards to be issued.

  In terms of product standards, there are currently no national and industrial standards related to self-heating instant hot pot products and heating packages in China. In fact, this unpredictable but possible security risk needs to be clearly reminded before users use it. However, the reporter found that at present, no self-heating product on the market has made a clear warning against these problems.

  Cai En, director of the Consumer Guidance Department of the Shanghai Consumer Rights Protection Committee, said: "The manufacturer of heating packs should first make further tests and analysis on the components and related proportions of its heating packs, including the weight, to ensure that this heating pack can fully respond and ensure the safety of consumers when using it."

  In this test, 18 samples of heating packages were marked with main components and corresponding enterprise standard codes. According to the marked main components, it can be divided into two groups: group ⅰ is calcium oxide, aluminum particles and sodium bicarbonate; Group II is calcium oxide, aluminum powder, sodium carbonate and sodium hydroxide. The heating packages of the other two self-heating instant hot pot samples were not marked with ingredients and enterprise standard codes.

  According to the Catalogue of Hazardous Chemicals (2015 Edition) issued by state administration of work safety and other ten ministries and commissions, "aluminum powder" belongs to hazardous chemicals. In the list of dangerous goods in the United Nations Model Regulations on the Transport of Dangerous Goods, "uncoated" aluminum powder belongs to the listed 4.3 substances that release flammable gases when meeting water; Sodium hydroxide belongs to the listed class 8 corrosive products. When transported by air, calcium oxide belongs to the eighth corrosion product listed in the list. The heating package belongs to the substances listed in the list that release flammable gas when it meets water.

  According to the classification standard of the United Nations "Recommendations on the Transport of Dangerous Goods Model Regulations", the self-heating instant chafing dish products are dangerous goods in transportation, because of the danger of releasing flammable gas when encountering water.

  Therefore, China’s civil aviation system has completely banned the carrying of self-heating products on the plane. The regulations on railway safety management issued by Guangxi also clearly stipulate that it is forbidden to use self-heating food on bullet trains.

  Use reminder

  Shanghai Consumer Protection Committee reminds consumers:

  ● Read the instructions of the product before use, and operate in strict accordance with the prompts, especially not in closed and narrow environments such as cars, avoiding naked flames, and minors can use it under the guidance of adults.

  ● When using, please pay attention to placing the product on the anti-scalding table, and avoid touching the outer pot to avoid scalding.

  ● After use, the instant chafing dish garbage should avoid massive accumulation or direct contact with water, and be classified according to the regulations of Shanghai Municipal Domestic Waste Management, and the used heating package should be classified and disposed according to harmful waste.

  Self-heating food raw materials have the problem of nutrient loss.

  Chen Rong, president of the Nutritionist Association of Heilongjiang Province and a national first-class nutritionist, said that the nutritional value of vegetable raw materials in self-heated food could not be compared with that of fresh vegetables.

  Comprehensive CCTV, interface news, life newspaper, etc.