Produced jointly by Wenhuaren (Beijing) Culture Media Co., Ltd. and Fengxing Online, the highly anticipated short play "Clouds Going Up" will be officially launched on May 10th. With its unique world outlook of coexistence of ancient martial arts civilization and modern civilization, the play has attracted a large number of audiences’ attention. In this work, Shi Fei Da, a powerful actor, will play Wen Yu, the eldest brother of the three brothers and sisters of the Wen family, which has attracted strong attention from fans.

Shi Feida, who is 178cm tall and weighs 65kg, has a handsome appearance and unique temperament. He is a versatile actor with rich acting experience. As early as 2010, he partnered with Ni Ping, a famous actor and host, to host the Third China Artists Awards Ceremony in world artists association, USA, and won the Best Newcomer Award. This honor not only affirmed his hosting talent, but also predicted his infinite possibilities in the future.

While at school, he was lucky enough to participate in the film Far away Xilin Gol directed by the famous director Gao Feng, and he played Guo Qinglin (first hero), an educated youth in Beijing, and accumulated valuable performance experience. After graduation, he devoted himself to the shooting of many main melody films, constantly challenging himself and improving his acting skills.

In the anti-Japanese war film Sun Face directed by Xinyun Zhu in 2013, Shi Feida played Zhou Maosong, and his superb acting skills and solid lines were widely recognized in the industry. Whether it is the emotional expression of the role or the interpretation of the action play, he has shown excellent professionalism and acting talent.

In addition, Shi Feida’s performance in the film field is also quite eye-catching. His film works include Strange Crime, Qian Xuesen, Far-off Xilin Gol, Lost, Music and Whose Child. In these works, he created many characters with different personalities and distinct images, which showed his diversity and plasticity as an actor.

In the upcoming short play "Clouds Going Up", Shi Fei Da will play Wen Yu, the eldest brother of Wen Ji’s family, which is a role full of sense of justice and responsibility. In Yun Kaminooji, a world where ancient martial arts civilization and modern civilization coexist, he will lead his younger brothers and sisters to protect ancient martial arts civilization, maintain modern order and present a legendary heroic image for the audience.

Shi Feida said that he was very excited and looking forward to playing such a role. He believes that the story background and role setting of "Up in the Clouds" are very attractive, and he will devote himself to shaping the role and bring a brand-new and unforgettable performance to the audience. With the upcoming launch of Clouds Going Up, the audience are full of expectations for Shi Feida’s performance in the play. I believe that he will bring a double feast of vision and mind with superb acting skills and profound performance skills.

"Clouds Going Up" is not only a wonderful short play that combines ancient martial arts civilization and modern civilization, but also a masterpiece that shows the brilliance of human nature and heroic feelings. With the participation of many outstanding actors such as Shi Fei Da, the play will surely become the focus of the audience’s attention. Let’s look forward to the arrival of May 10th and witness the wonderful performance of Shi Feida in Clouds Up.

    On November 15th, the national launch of the third generation power station of Easy Connect was held in Hangzhou, marking another solid and important step for Easy Connect in the field of automobile power exchange. The third-generation power station of Yiyi Interconnection has made greater breakthroughs in the aspects of "power exchange speed, power exchange reliability and power exchange safety guarantee", which also indicates that the operating market is welcoming the "power exchange outlet".

   The power exchange mode is a "potential stock", which will effectively complement the charging mode.

    As one of the important ways to replenish energy for new energy vehicles, the power exchange mode has always been an important direction to promote new energy infrastructure construction. In October, 2021, the Notice on Launching the Pilot Work of the New Energy Vehicle Switching Mode decided to launch the pilot work of the new energy vehicle switching mode application. There are 11 cities included in the pilot scope, including 8 comprehensive application cities (Beijing, Nanjing, Wuhan, Sanya, Chongqing, Changchun, Hefei and Jinan). In July 2023, "Several Measures on Promoting Automobile Consumption" proposed to speed up the popularization, application and construction of the power exchange mode.

    Although the current mainstream market for new energy vehicles is charging, according to market research and analysis of relevant experts, the mode of replacing electricity also has huge market potential and industrial expansion space.

    In the future, changing electricity will inevitably become one of the most important ways to replenish energy in the new energy vehicle market, and it is a "potential stock" for industrial upgrading, which will effectively complement the charging mode.

    "Easy Connect Technology Co., Ltd.", a subsidiary of Geely Automobile Group, is a firm practitioner and active promoter of automobile power exchange mode. In January 2017, the R&D team of power exchange technology was set up; In September 2020, the Chongqing Exhibition Station was completed, and the power exchange mode was released for the first time; In January 2021, he won the "Golden Intelligence Award of the Year" in the third China Automobile Golden Coconut Award; In September 2021, as a new power for power exchange, it appeared at the Beijing New Energy Automobile Industry Development Achievement Exhibition; In October, 2023, the brand vision was released: to build the first brand in the operation market.

   Create the industry’s first smart electricity exchange ecological platform and become a "strength school" for big travel.

    Easy Internet has been deeply involved in the power exchange industry for more than 6 years, and has accumulated leading industry experience. It has more than 1,000 R&D personnel and invested more than 1 billion yuan. It has thousands of technical patents in the power exchange fields such as "power exchange architecture, power exchange station, standardized battery pack, power exchange vehicle, and station control cloud platform", and has issued more than 30 related standards for power exchange, and its reliability verification test has exceeded 300,000 kilometers, making it the first in the industry to have "complete vehicle-battery".

    According to Yang Quankai, president of Yiyi Internet Technology Co., Ltd., Yiyi Internet’s third-generation power station has the advantages of "high modularity, high compatibility, high intelligence, high service capacity and high security", reshaping the new experience of replacing electricity and replenishing energy.

    (1) High modularity: The power station adopts a highly integrated modular design concept, which can increase or decrease the number of boxes according to the service capacity, realize rapid disassembly, strong reproducibility and rapid deployment, and can stop at the station within 24 hours at the earliest. The single station of the power exchange station covers an area of 120-200m2, with small floor space and high efficiency ratio.

    (2) High compatibility: the unique open power exchange platform architecture can achieve multi-vehicle compatibility and achieve wheelbase bandwidth coverage of 2700-3100mm. It has opened customized service for vehicles to the market, promoting the coordinated development of technology and the promotion of power exchange technical standards. The adaptive ambient temperature range of the power station is-30 ~ 55 C, which can adapt to the low temperature weather in most northern winters.

    (3) High intelligence: the intelligent temperature control system under all-weather conditions has the characteristics of constant temperature and slow charging, dynamic inspection, etc., which ensures the intelligent control of the whole charging environment, realizes the interconnection of vehicles, stations and cloud platforms, and realizes integrated operation.

    (4) High safety: The power exchange station has a three-level fire protection system, and 24-hour cloud monitoring is implemented for the power exchange battery by using 5G technology, and the battery life is prolonged by constant temperature and slow charging. Seven-layer safety measures are adopted to ensure the safety of the battery and the power exchange station, and advanced locking mechanism design has established a safety barrier in the whole process of power exchange.

    (5) High service capability: With the intelligent power exchange management system, the automatic power exchange operation can be unmanned, and the whole process takes less than 1.5 minutes (the mechanical power exchange part can be completed in 40 seconds at the earliest), and the number of power exchanges in a single station is ≥540 times a day, saving 1-2 hours for drivers in each shift. The annual power exchange capacity of a single station can reach 7 million kWh, and the annual revenue of a single station can reach 10 million yuan.

    In the next three years, Yiyi Interconnect will operate 2,000 power exchange stations nationwide, and unite the efforts of all parties to provide high-quality power exchange and energy replenishment services for drivers, making power exchange faster than refueling; At the same time, E-easy Internet will also launch power exchange and energy replenishment solutions that specifically match the operating market, and build the first brand of power exchange and energy replenishment in the operating market. Up to now, Yiyi Interconnect has deployed and operated over 300 power stations in more than 30 cities including Chongqing, Hangzhou, Guangzhou, Chengdu, Tianjin, Jinan, Xi ‘an and Shenyang. The number of power changes per day exceeds 20,000 times, and the power change per day exceeds 600,000 kWh, and the operating data is growing steadily.

    At present, there are "Cao Cao 60, Maple Leaf 80v, Maple Leaf 60s, Ruilan 9, Ruilan 7, British TX5" which can be used for power exchange in the power exchange station of Easy Connect. More automobile brands are developing power exchange models and joining the power exchange system of Easy Connect one after another.

    Change the electricity to the windward port, and the break is in the present. As an important part of the new energy vehicle industry, the development of power exchange mode is of great significance to promote the popularization and application of new energy vehicles. With its long-term accumulation of outstanding technical strength and strategic layout of the operating market, Easy Internet is bound to lead the industry trend and help the industry upgrade.

　　Text/Yangcheng Evening News reporter Zhang Hua correspondent Wu Yuantuan Xu Jianying

　　Why do Chinese medicine practitioners who can keep in good health always make you eat less cold things? Yan Fang, director of the Classic Department of Traditional Chinese Medicine of Guangdong Provincial Hospital of Traditional Chinese Medicine, believes that if we want to be healthy, we must first protect our own yang, because the warmth of the yang makes our body move normally. The biggest harm of cold things lies in the loss of human yang, which leads to the weakening of human function. After the weakening of human visceral function, it is easy to cause stagnation of qi and blood stasis. Many of our diseases come from these bad habits that damage yang.

　　Habit 1 Eat a lot of fruit every day.

　　Fruit is rich in vitamins and dietary fiber, which is good for skin and body. So many women eat a lot of fruit every day, eat watermelon and cut it in half, and dig it with a spoon; Eating a bunch of grapes is like eating melon seeds.

　　Yan Fang, director of the Classic Department of Traditional Chinese Medicine of Guangdong Provincial Hospital of Traditional Chinese Medicine, believes that healthy people should eat 250-400g of fruit every day. Western medicine pays attention to the ingredients of fruit, such as "rich in vitamins", but Chinese medicine pays attention to its properties. However, we often ignore the cold or wet weight of fruits, and the storage and transportation are mostly refrigerated. In addition, our Lingnan area has the characteristics of less mountains and more water, and more cold in the middle soil.

　　Modern people, however, are generally cold because of their love of cold drinks, excessive stress and fatigue, abuse of antibiotics, frequent air conditioning and many other factors. This kind of physique, especially for cold and cold fruits, should be cautious and not eat more. Otherwise, excessive cold and dampness will hurt the spleen and stomach, leading to loss of appetite, loose stool, fear of cold and even eczema.

　　Yan Fang suggested that people who are cold and wet should not eat too much fruit. The ancients paid great attention to this point. They didn’t eat fruit on an empty stomach, the infirm didn’t eat fruit, and children and the elderly didn’t dare to give too much fruit to eat. For patients with deficiency cold and particularly greedy mouth, Yan Fang suggested that when eating fruit, a small amount of boiled water should be used for soaking or boiling, which can slightly reduce the coldness. Knowing your physique, choosing the fruit that suits you and tasting it in moderation are the "health tips" for eating fruit.

　　Habit 2 Drink herbal tea at every turn

　　There are few mountains and low terrain in Lingnan area, which shows that "rustic" is thin. The spleen and stomach belong to the soil, which will inevitably affect the function of the spleen and stomach. In addition, the climate here is hot and humid, and everyone thinks that it is necessary to remove more dampness and heat. Herbal tea can clear fire and quench thirst, and it tastes good. There are herbal tea shops all over the street, and the sales are also good.

　　However, eating too much herbal tea that can clear away heat, detoxify and eliminate dampness will further damage the spleen and stomach. The soil is thin and "the soil does not contain fire", so it is naturally easy to "fire" as a disaster!

　　Yan Fang said that repeated fires are mostly caused by deficiency fire, such as dry mouth and bitter taste, red eyes, oral ulcers, swollen gums, sore throat, nosebleeds, dry stools and so on. At the same time, it is accompanied by symptoms such as dull tongue color, pale lips, thin white or slightly greasy tongue coating, light urine color and smell, dry mouth and no desire to drink more, five upset and hot (hands, feet and heart, collectively called five hearts), insomnia and irritability, so the real cure for fire is to regulate the spleen and stomach. If the "rustic" is thick, it will naturally be difficult to get angry!

　　It is not necessary to put out the fire at the sight of the fire, but to get angry and reduce the fire. Drinking too much herbal tea will hurt Zhongyang, and the health will be damaged the day after tomorrow, causing endless harm. The correct way is that herbal tea should be moderate and lead to fire.

　　Habit 3: I have no time during the day and exercise at night.

　　The pace of work and life in the city is fast, and I really don’t have time to exercise during the day. After work, the night is clean, the weather is cool, running and playing ball games, and I feel very sour and refreshing. Plus, there is another reason to eat supper after exercise. Therefore, many people have no time during the day and are used to doing sports at night.

　　Yan Fang believes that improper exercise is better than no exercise. Night exercise calls the human body’s yang, which is contrary to the natural law of "doing at sunrise and resting at sunset", and even affects sleep and rest at night. In addition, supper will hurt the spleen and stomach.

　　Therefore, Yan Fang does not advocate night exercise, and it is the way to keep fit at sunset.

　　Habit 4 Stay up late and make up during the day.

　　At present, young people are under great work pressure and have many recreational activities. Many people are willing to overdraw their physical strength and consume their blood excessively. For example, they always like to stay up late. Others think that if you stay awake at night, you can make up your sleep time the next day.

　　In fact, staying up late is the most harmful to qi and blood. Therefore, people who stay up late usually look haggard and tend to get old. Chinese medicine believes that what is consumed during the day is the yang of the body, and sleeping at night can make the yang get full rest and nourishment. Staying up late for a long time will disturb the balance of yin and yang, qi and blood in the body. Various organs of the body may have different symptoms.

　　Yan Fang believes that the Tao is to preserve one’s health naturally, to do it at sunrise, to rest at sunset, and to stay up late at night is to call the sun be the spirit. Sleeping during the day is to block the yang, and you are not staying up at night, but living.

　　Habit 5 wash your nose with cold water every day

　　Patients with "allergic rhinitis" are very common, and most of them are allergic and have certain heredity. External stimuli, including cold air, pollen, indoor dust, mites, molds, animal hair, dander and poultry feathers, can all lead to nasal itching, continuous sneezing and a lot of clear water-like serous nasal secretions. Each attack lasts for more than one hour and often recurs.

　　Many people are used to washing their noses, thinking that it can clean the bacteria in the nasal cavity, enhance the resistance of the nasal cavity, strengthen the ventilation and drainage of the sinuses, and promote local blood circulation.

　　However, Yan Fang believes that this will consume the body’s yang, reduce the body’s resistance, take the initiative to induce cold pathogens to invade, and lead to recurrent rhinitis.

　　Experts say that washing the nose with cold water does not cure the symptoms, especially cold water washing the nose adds cold to the cold, which encourages cold pathogens to hide in the house, which is not beneficial but harmful. (Watchmaking/Du Hui)

　　On July 6, Shu Yuting, spokesperson of the Ministry of Commerce, introduced at a regular press conference that from January to May 2023, China’s service trade maintained an overall growth trend. The total import and export of services was 2,605.54 billion yuan (RMB, the same below), up 10.2% year-on-year. Among them, exports were 1,098.22 billion yuan, down 4.7%; Imports reached 1,507.32 billion yuan, up by 24.2%; The service trade deficit was 409.1 billion yuan.

　　Kevin·Z, an associate researcher at China Service Outsourcing Research Center, told the Economic Information Daily that the growth of China’s service trade continued to improve from January to May, and the import and export volume of services achieved double-digit growth year-on-year. It can be predicted that with the acceleration of international cooperation in China’s service industry, China’s total service trade will reach a new high in the whole year.

　　It is worth noting that while the total volume has maintained rapid growth, the structure of China’s service trade has continued to optimize, and the proportion of knowledge-intensive service trade has increased. From January to May, the import and export of knowledge-intensive services was 1,122.78 billion yuan, up 13.6% year-on-year, accounting for 43.1% of the total import and export of services, up 1.3 percentage points over the same period of last year. Among them, the export of knowledge-intensive services was 656.59 billion yuan, up by 17.2%, and the import of knowledge-intensive services was 466.19 billion yuan, up by 8.8%.

　　In Kevin·Z’s view, this is the concrete embodiment of the continuous improvement of the development quality of China’s service trade. "From the data point of view, China’s knowledge-intensive service trade continued to maintain a rapid growth trend in the first five months, accounting for a steady increase in the total import and export of services, and has become the strength to build a new development pattern of services and promote the high-quality development of trade in the new era."

　　In addition, travel services have obviously recovered. From January to May, the import and export of travel services reached 552.54 billion yuan, a year-on-year increase of 67%, making it the fastest-growing service trade field. Among them, exports increased by 53.4% and imports increased by 68.1%. Kevin·Z analyzed that from January to May, China’s travel service achieved a leap-forward growth, with a year-on-year increase of over 60%, and the recovery momentum was strong, which became an important driving force for the steady growth of service trade.

　　The favorable factors for the development of China’s service trade are still accumulating. Kevin·Z said that with the accelerated popularization of the new generation of information technology and the accelerated development of digitalization and intelligence, digital trade with digital technology, digital products, digital services and data information as its subject matter is booming. China’s digital industry has developed rapidly. At present, it is the second largest digital economy in the world, with a number of digital enterprises with strong international comparative advantages. At the same time, it benefits from a super-large market with a population of 1.4 billion, which provides fertile ground for the development of digital trade and has great development potential. In the future, digital trade will become a new engine for the development of China’s service trade, and will also make greater contributions to the prosperity and development of global trade.

　　According to the Southeast Network (Reporter Feng Chuanye correspondent Song Yaxin), the "May Day" holiday is coming, and many car owners have already made travel plans. The reporter learned from Fujian Expressway Energy Company that Fujian Expressway has laid out charging stations in more than 100 pairs of service areas and built more than 900 charging piles, of which the coverage rate of fast charging stations is as high as 88%, and the charging service network of expressway intercity traffic in the province has basically taken shape.

　　This year’s "May 1 ST" holiday arrangement is: April 29 to May 3, a total of 5 days. Free passage time is five days during the May Day holiday in 2023 (from 0: 00 on April 29th to 24: 00 on May 3rd), and Fujian Expressway will continue to implement the free passage policy for passenger vehicles with less than 7 seats (including 7 seats).

　　The high-speed department predicts that the public’s willingness to travel during the "May 1" Golden Week this year is very strong. Combined with the comprehensive analysis and judgment on the changes of expressway traffic in the whole province during the May Day holiday in recent years and the Qingming holiday this year, it is predicted that the overall expressway traffic in our province will rise sharply during the May Day holiday this year, which is expected to break through the level of the same period in previous years and hit a new record high. The travel groups are mainly long-distance inter-provincial tours and short-distance trips to go on road trip. It is suggested to plan the route scientifically and rationally stagger the peak trips.

　　In order to facilitate the travel of electric car owners, Fujian Expressway has sorted out the list of service areas where charging stations have not yet been laid out, helping car owners to plan their trips in advance, avoiding entering the service area without charging stations by mistake and improving charging efficiency.

　　The service area of the charging station has not yet been laid out as follows:

　　Fuzhou area: Longtian service area of Fuzhou-Xiamen Expressway and Wutong service area of Puyan Expressway;

　　Zhangzhou area: Huangtian service area of Pingmei Expressway, Banzi Yutang service area and Meifeng service area of Guping Expressway;

　　Longyan area: Rentian Service Area of Zhangwu Expressway, Ancient City Service Area of Xiamen-Chengdu Expressway and Tufang Service Area;

　　Sanming area: Fengxi service area, ancient ginkgo service area of Shaxia Expressway and Dajin Lake service area of Puwu Expressway;

　　Tips for using charging piles

　　1. During the charging process, the vehicle should be parked and turned off, and it is not allowed to move at will.

　　2. Check the charging pile, charging cable and charging gun for obvious appearance damage before charging the gun. If there is any damage, charging should be prohibited.

　　3. When charging, the charging gun should be inserted to the end, otherwise the equipment protection function will be prohibited from being electrified.

　　4. After starting charging, the charging equipment and lines are electrified at this time. Despite multiple protection measures, you should try to avoid touching the charging equipment again.

　　5. It is forbidden to plug and unplug the charging gun forcibly when the charging is not over, and it is forbidden to press the emergency stop button in non-emergency situations.

　　6. Non-professional operation and maintenance personnel are strictly forbidden to disassemble or modify the charging equipment.

　　Situation of high-speed power exchange stations in the province

　　In cooperation with Weilai Energy Company, Fujian Expressway Energy Company has operated five power stations in three pairs of service areas with large traffic and high power demand in the province, including one second-generation power station and four third-generation power stations.

　　Compared with the second-generation station, the third-generation power station has the advantages of higher efficiency, stronger service and smarter operation. It only takes 3-4 minutes to complete the power exchange, and the daily service times can reach 408 times, which can realize the functions of calling vehicles and automatically changing power, and can comprehensively improve the experience of power exchange owners.

　　Tips for using Weilai Power Station

　　1. Navigate to the nearest power exchange station by calling NOMI, and the locomotive system will prompt whether it is necessary to make an appointment for power exchange in advance, click OK, and then go directly to the power exchange station;

　　2. After arriving at the power exchange station, a power exchange prompt will pop up on the central control panel, and the owner can choose to park automatically and enter the power exchange station, or back up by himself and let the power exchange station staff back up and enter the power exchange station;

　　3. After the vehicle stops in the power exchange station, it will automatically start to change power. After the power exchange is completed, the vehicle will give a prompt, and then it can directly drive out of the power exchange station.

　　In the next step, Fujian Expressway will encrypt the network layout of power stations, and strive to achieve one power station every 100 kilometers of expressway. It is estimated that 11 power stations will be added to Fujian Expressway during the year, which will radiate the sections of Shenhai Expressway, Jingtai Expressway and Changshen Expressway in the province. This will greatly enhance the convenience service capacity and provide a strong "green power support" for high-speed electric vehicles to travel to Fujian Expressway.

On February 9th, Mary, the actor who made his eighth appearance on the stage of the Spring Festival Evening, came to the interview room. She said that every time she comes to the Spring Festival Gala, like the exam, she is particularly nervous and under great pressure. When she has good works, she will be more confident in acting, but this year’s time is relatively hasty.

Mary said that it is actually more difficult for an actress to act in comedy than an actor, because she is not willing to "sell" or "play", but rather wants to start from the characters, so whether it is the structure or the character of the role, it is still more challenging to act.

Talking about the upcoming film Article 20, Mary said that he didn’t expect to cooperate with director Zhang Yimou one day. From the day he joined the group, he felt that everything was like a dream. Mary also said that Zhang Yimou’s state of filming on the spot, his unique ideas, his requirements for actors and his control of all the plays made him feel that the director is the most attractive and soul person in the crew and the soul of a movie. "I think the director is like a god to me."

Recalling that in 2023, Mary admitted that he was a model worker. Last year, there were 3 or 4 films and played some very powerful female roles. The creative process was happy, but it was also very painful. The result was very satisfactory for himself. I hope I can give myself a holiday in the new year.

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10moon17The 9th china international forum on work safety Fire Safety Sub-forum, hosted by the Fire Rescue Bureau of the Ministry of Emergency Management and undertaken by the China Fire Protection Association, was held in Hangzhou, Zhejiang. Experts and scholars from domestic and foreign fire protection fields had in-depth exchanges around "strengthening fire accident prevention and promoting the development of fire protection". Zhou Tian, Chief Engineer of Fire Rescue Bureau of Emergency Management Department, presided over the sub-forum, and Chen Weiming, President of China Fire Protection Association, attended and delivered a speech. Responsible persons of fire departments of fire brigades, responsible persons of fire research institutes and fire product conformity assessment centers, as well as representatives of relevant scientific research institutions, research institutions and enterprises.300More than 200 people attended the sub-forum, and at the same time, the Japanese Fire Protection Association, national fire protection association, the International Federation of Fire Protection Associations and German were invited.VDSExperts and scholars of certification bodies.

Zhou Tian said that this forum is the first large-scale international forum held after the establishment of the Emergency Management Department. During this period, a sub-forum on fire safety was established for the first time, which fully reflected the concern and attention of the Emergency Management Department to the fire-fighting cause and the integration and docking of fire-fighting work and safety production work.

Chen Weiming said in his speech that as the organizer of this china international forum on work safety fire safety sub-forum, it is very meaningful for China Fire Protection Association to provide a high-standard communication platform for fire professionals from all corners of the country.

This sub-forum on fire safety invited domestic fire departments, scientific research institutes, universities, fire-fighting enterprises and fire-fighting experts and scholars from overseas to hold.14The keynote speech included not only the latest achievements in fire risk analysis and prevention and control technology research of high-rise and underground buildings, petrochemical enterprises, large-scale urban complexes and new energy vehicles, but also smart fire protection construction, external wall insulation materials, fire accident investigation, volunteer fire brigade management and certification of domestic fire protection products entering overseas markets, which are all hot, difficult and focus issues in current fire safety work.

Participants in the sub-forum said that it is very rare for Chinese and foreign counterparts to have such an exchange opportunity. Through one day’s discussion and exchange, they not only enhanced mutual understanding, but also enhanced cooperation and friendship, and gained a lot.

　　
General Office of Guangdong Provincial People’s Government on Promoting and Standardizing

Implementation opinions on the application and development of big data in health care

People’s governments at the local level and listed, people’s governments of counties (cities, districts), departments and institutions directly under the provincial government:

　　In order to implement the Guiding Opinions of the General Office of the State Council on Promoting and Standardizing the Application and Development of Big Data in Health Care (Guo Ban Fa [2016] No.47), adapt to the development trend of big data technology, promote and standardize the integration, sharing and open application of big data in health care, improve the medical service capacity and improve the health level of the people, with the consent of the provincial people’s government, we hereby put forward the following implementation opinions.
　　I. General requirements

　　(1) Guiding ideology. We will fully implement the spirit of the 18th CPC National Congress and the Third, Fourth, Fifth and Sixth Plenary Sessions of the 18th CPC Central Committee, thoroughly implement the spirit of the series of important speeches by the Supreme Leader General Secretary and the new ideas, new ideas and new strategies for governing the country, conscientiously implement the decision-making arrangements of the CPC Central Committee, the State Council, the provincial party committee and the provincial government, adhere to the concept of innovation, coordination, green, openness and shared development, take the protection of people’s health as the starting point, adhere to people-oriented, innovation-driven, standardized, orderly, safe and controllable, The principle of open integration, co-construction and sharing, consolidate the grassroots foundation, improve the policy system, innovate the working mechanism, vigorously promote the interconnection, integration and open sharing of government health care information systems and public health care data, fully stimulate the innovation vitality of health care big data, explore new applications of data, innovate new service models, foster and develop new formats, provide strong support for building a strong health province and a healthy Guangdong, and make positive contributions to achieving the goal of "three orientations and two firsts".
　　(2) objectives and tasks.
　　—— By the end of 2017, a provincial-level comprehensive health information management platform with complete functions and unified authority will be initially established to realize interconnection with the national population health information platform. Realize the interconnection between the provincial drug bidding and purchasing business application supervision platform and the national drug supply security comprehensive management information platform.
　　—— By the end of 2018, all the listed and county (city, district) national health information comprehensive management platforms have been built at all levels, and connected with provincial platforms, forming an efficient and unified network covering all kinds of medical and health family planning institutions at all levels, and realizing business application interconnection, information sharing and effective collaboration.
　　—— By the end of 2020, the province’s health care data will be shared with basic data resources such as population, legal person, spatial geography and environment across departments and regions, and the data fusion application in medical care, medicine, medical insurance and health-related fields will achieve remarkable results, and the new format of health care big data application will flourish, initially forming a health care big data industry system. Health care big data application standard system, data security and privacy protection system, relevant policies and regulations have been continuously improved, the quality of health care services has been significantly improved, and the people have received more benefits.
　　Second, accelerate the construction of a shared and open health care big data application infrastructure system.

　　(1) Accelerate the construction of "one network, three platforms and three databases". Strengthen the top-level design and implement the Guangdong "Healthy Cloud" service plan. Integrate and utilize existing facilities and resources such as e-government extranet, network operator network and government cloud resources, and accelerate the construction to form a private network for health care services covering provinces, cities, counties (districts), townships (towns) and villages (residences). We will build a unified and authoritative comprehensive management platform for national health information at the provincial, municipal and county levels, connect all kinds of medical and health institutions at all levels, and strengthen data collection, integrated sharing and business collaboration of application information systems such as public health, family planning, medical services, medical security, drug supply and comprehensive management. Strengthen the maturity evaluation of interconnection of the comprehensive management platform of national health information at city and county levels, and improve the level of interconnection. Establish three unified databases of the whole province, namely, full population, electronic health records of residents and electronic medical records, and build a provincial-level national health big data center with the three databases as the core. (Provincial Health and Family Planning Commission, Development and Reform Commission, the municipal people’s government is responsible for all localities, and the Provincial Economic and Information Commission, the Public Security Department, the Department of Finance, the Department of Human Resources and Social Security, and the Food and Drug Administration cooperate, and the first department is the lead department, the same below)
　　(two) to speed up the upgrading of medical and health institutions information system. Accelerate the transformation and upgrading of the information system of medical and health institutions with electronic medical records as the core, reduce repeated investment and improve the efficiency of information construction. To break the data chimney formed by vertical business information system and the data island formed by isolated business information system, the information systems of medical and health institutions at all levels should all be connected with the comprehensive management platform of national health information of provinces, cities and counties, and realize data fusion within medical and health institutions and data sharing between medical institutions and between medical institutions and public health institutions. Strengthen the maturity of information system interconnection and evaluation of the application level of electronic medical record system in medical and health institutions, and improve the application level of electronic medical record. (Provincial Health and Family Planning Commission, the municipal people’s governments at all levels are responsible, and the Provincial Development and Reform Commission, the Economic and Information Commission, the Finance Department and the Human Resources and Social Security Department cooperate)
　　(3) Establish a mechanism for the collection, sharing and opening of health care data.
　　Promote the interconnection of the government health care information system with the three databases of the whole province’s population, residents’ electronic health records and electronic medical records, share data, and cooperate with business applications efficiently. Effectively collect data on medical services, traditional Chinese medicine, biomedicine, insurance supervision, research and development and management of drugs and medical equipment, inspection and quarantine, public health, population management, education and scientific research, food and agriculture, meteorological environment, physical fitness, etc., support management model innovation and e-government development, and realize the collection of health care data, business matters and health decision-making on the platform. (Provincial Health and Family Planning Commission, Economic and Information Technology Commission are responsible, and all relevant units cooperate)
　　Combined with the needs of the "one-door, one-network" government service model, we will further promote the sharing of government data related to population and health, and smooth the data sharing channel. The establishment of centralized management of health and family planning departments, Chinese medicine, development and reform, education, science and technology, economy and informatization, public security, civil affairs, human resources and social security, environmental protection, agriculture, commerce, safety supervision, inspection and quarantine, food and drug supervision, sports, statistics, tourism, meteorology, insurance supervision, Disabled Persons’ Federation and other departments closely cooperate with the regular exchange and sharing mechanism of health and medical data. (Provincial Health and Family Planning Commission, Economic and Information Technology Commission are responsible, and all relevant units cooperate)
　　Strengthen data quality management, establish and improve the standards of health care data collection, cleaning, warehousing and storage, establish a data quality evaluation mechanism, insist on controlling data quality from the source, and ensure that health care data is legal, authentic, effective and available. Explore the development of desensitization and opening methods for residents’ health care privacy information, build and improve the open platform for health care data, smooth the open channels of data, and steadily promote the opening of health care big data. Explore the establishment of Guangdong health care data resource catalogue system, and make a good connection with the national health care data resource catalogue. (The Provincial Health and Family Planning Commission is responsible, and the Provincial Development and Reform Commission, the Economic and Information Commission and the Legislative Affairs Office cooperate)
　　Third, comprehensively deepen the application of big data in health care

　　(1) Promote the application of governance big data in the health care industry.
　　Establish and improve the monitoring and evaluation index system and evaluation model for deepening the reform of medical and health system, realize real-time monitoring of key indicators such as medical service price, medical insurance financing and payment, control of residents’ medical burden, and drug use, deepen the accurate evaluation of the reform effect of medical and health system, and improve the pertinence and effectiveness of reform decisions. Strengthen the application of evaluation and monitoring results, and promote the formation of a new model of health management decision-making based on data, such as industry supervision, performance evaluation, input compensation and personnel compensation. (Responsible for the Provincial Health and Family Planning Commission, with the cooperation of the Provincial Development and Reform Commission, the Department of Finance and the Department of Human Resources and Social Security)
　　Open the data channel between medical institution management information system and clinical information system, integrate and analyze clinical, operation, cost accounting and quality evaluation data, build an evaluation system of medical institutions with comprehensive information, scientific evaluation, authoritative conclusion and timely update, improve the authority and credibility of evaluation results, and link it with hospital evaluation, fund allocation, performance pay, etc., promote the deepening of public hospital reform, improve modern hospital management system, and promote the improvement of hospital operation management level and medical service quality. (Responsible for the Provincial Health and Family Planning Commission, with the cooperation of the Provincial Development and Reform Commission, the Department of Finance and the Department of Human Resources and Social Security)
　　We will improve the monitoring mechanism for the income composition and changing trend of medical institutions, such as medical care, medicines and medical consumables, and cooperate with business information such as medical service price, medical insurance payment, bidding and purchasing of medicines and medical consumables, drug use and medical expense control, strengthen the monitoring and early warning of anti-fraud of medical insurance, and promote the joint reform of medical care, medical insurance and medicine. Accelerate the integration of comprehensive supervision information on health and family planning, realize the interconnection between comprehensive supervision and law enforcement information and health care related information systems, and improve the level of industry supervision. (The Provincial Health and Family Planning Commission is responsible, with the cooperation of the Provincial Development and Reform Commission, the Economic and Information Commission, the Department of Finance, the Department of Human Resources and Social Security, the Food and Drug Administration and the Bureau of Traditional Chinese Medicine)
　　(2) Promote the application of big data in clinical medical care and scientific research. Make full use of national key clinical specialties, provincial key clinical specialties, national and provincial key laboratories and other advantageous resources, rely on the National Clinical Medical Research Center, the National Traditional Chinese Medicine Data Center and the collaborative research network, base on South China, face Hong Kong, Macao and Taiwan, and radiate to Southeast Asia, and build a number of regional clinical medical data demonstration centers in the directions of cardiovascular and cerebrovascular diseases, tumors, geriatric diseases, respiratory diseases, nephropathy, reproduction, orthopedics, hepatobiliary, pediatrics, maternal and child health care, occupational diseases and traditional Chinese medicine. Strengthen the integration and sharing of clinical medicine and basic medical research data resources, and improve the transformation and application efficiency of medical research. Relying on clinical medical data demonstration center, integrating medical service data, drug research and development evaluation and management data, traditional Chinese medicine data and biomedical data, developing clinical decision support system to support clinicians to improve work efficiency and diagnosis and treatment quality. Promote the application of biomedical technologies such as gene chip and sequencing technology in genetic disease diagnosis, early cancer diagnosis and disease prevention and detection, realize the effective docking of genome information and electronic medical records, and promote the development of precision medical technology. Establish a genome database and a database of specialized subjects and diseases, and promote the research and application of disease markers. Create a number of precision medical specialties and precision medical pilot hospitals. (The Provincial Health and Family Planning Commission and the Chinese Medicine Bureau are responsible, and the Provincial Development and Reform Commission, the Economic and Information Commission, the Science and Technology Department and the Food and Drug Administration cooperate)
　　(3) Promote the application of public health big data. Promote the interconnection between various national special newspaper information systems and the comprehensive management platform of national health information at the provincial, city and county levels. We will improve information systems such as immunization planning, online direct reporting, online first aid, management and treatment of severe mental disorders, prevention and control of occupational diseases, early warning and decision-making of public health risks at ports, and the application functions of mobile emergency business platforms, so as to enhance the ability of public health monitoring, evaluation and decision-making management. Integrate social network public information resources and improve the early warning mechanism of disease-sensitive information. Strengthen cooperation with the World Health Organization, international and public health institutions in Hong Kong, Macao and Taiwan, carry out research on the frontier technology of public health information, early warning and prediction research on the risk of sudden acute infectious diseases of international concern, and timely grasp and dynamically analyze the international public health risks such as the disease occurrence trend of the whole population and the global epidemic information of infectious diseases. Promote the information acquisition and information sharing of entry personnel in countries and regions where the epidemic broke out in advance, strengthen the business cooperation of inspection and quarantine, public health, foreign affairs, commerce, tourism, customs, port border inspection, maritime affairs, medical care, civil aviation, port services, railways and other units, prevent and control the imported epidemic, and improve the early warning and emergency response capabilities of public health emergencies. Promote the sharing of monitoring data of drug use, environmental sanitation, epidemiological factors monitoring, insect vector monitoring, drinking water, health hazard factors, port medical vector biology, nuclear biochemistry, food, meteorology, inspection and quarantine, sports, tourism and other industries, and effectively evaluate social factors affecting residents’ health by relying on residents’ electronic health records and electronic medical record databases.Carry out biological monitoring of key infectious diseases, occupational diseases, imported infectious diseases at ports and medical vectors, integrate multi-source monitoring data of infectious diseases and occupational diseases, establish a rapid identification network system for laboratory pathogen detection results, and improve the ability to prevent and control major diseases. (The Provincial Health and Family Planning Commission is responsible for the cooperation of all members of the joint meeting of the provincial prevention and control of major diseases)
　　(4) Promote the application of big data in traditional Chinese medicine. We will build a provincial platform for the management and utilization of big data resources of traditional Chinese medicine, a cloud platform for health information in TCM diagnosis and treatment areas, and a management information system for chronic diseases with TCM characteristics, health services and prevention of diseases. Improve and perfect the standards related to the analysis and application of big data of traditional Chinese medicine, build a big data center of traditional Chinese medicine and a database of diagnosis and treatment technology of traditional Chinese medicine covering medical treatment, prevention, health care, health preservation, rehabilitation, Chinese herbal pieces, Chinese patent medicines and hospital preparations, promote the application development of semantics of traditional Chinese medicine, data analysis and mining, intelligent diagnosis and treatment, knowledge management, vigorously develop "internet plus Traditional Chinese Medicine", realize diversified collection and in-depth analysis of big data resources of traditional Chinese medicine, and promote the convenience and benefit of smart Chinese medicine. Develop value-added services of TCM data resources and innovative services of TCM, and promote collaborative research on major diseases of TCM. (The Provincial Bureau of Traditional Chinese Medicine is responsible, with the cooperation of the Provincial Health and Family Planning Commission, the Development and Reform Commission, the Economic and Information Commission, the Science and Technology Department, the Civil Affairs Department, the Finance Department, the Culture Department and the Tourism Bureau)
　　(5) Cultivate new formats for the application of big data in health care. Strengthen key technologies such as storage and cleaning of massive data in health care, analysis and mining, and security and privacy protection. Accelerate the integration and innovation of health care data and new generation information and communication technologies such as cloud computing and big data, promote the deep integration of health care business and big data technology, and accelerate the construction of health care big data industry chain. Actively encourage social forces to innovate and develop health care business, and take various measures to support the development of health care service industry. Develop home health information services, standardize services such as online pharmacies and third-party distribution of medical logistics, and continuously promote the coordinated development of health care and health care, pension, housekeeping and other service industries. Promote the development of Chinese medicine, health care, health management, health consultation, health culture, physical fitness, health medical tourism, healthy environment, healthy diet and other industries. (The Provincial Health and Family Planning Commission is responsible, with the cooperation of the Provincial Economic and Information Technology Commission, Science and Technology Department, Civil Affairs Department, Culture Department, Sports Bureau, Tourism Bureau and Chinese Medicine Bureau)
　　(six) the development and promotion of digital health care intelligent equipment. Support the research and development of artificial intelligence technology, biological three-dimensional (3D) printing technology, medical robots, large-scale medical equipment, health and rehabilitation AIDS, wearable devices and related micro-sensor devices related to health care, accelerate the transformation of research and development results, improve the production and manufacturing level of digital medical equipment, Internet of Things equipment, smart health products, Chinese medicine functional status detection and health care instruments and equipment, and promote the upgrading of health care intelligent equipment industry. (The Provincial Economic and Information Technology Commission is responsible, with the cooperation of the Provincial Development and Reform Commission, the Health and Family Planning Commission, the Science and Technology Department, the Quality Supervision Bureau and the Bureau of Traditional Chinese Medicine)
　　Fourth, standardize and promote the development of "internet plus Health Care"

　　(a) the development of smart health care services for the convenience of the people. Integrate online and offline resources, and establish a "internet plus Health Care" service, payment and credit, health management and promotion system. Vigorously promote the application of Internet health consultation, online appointment and triage, mobile payment, intelligent guidance, whole process reminder and inspection results inquiry, follow-up, satisfaction feedback of medical industry and institutions, and form a standardized, shared, mutual trust and convenient health care service process. Develop third-party online health survey, consultation and evaluation, health management, health education and other application services to promote the quality of health care services. Promote the construction mode of new network hospitals such as online hospital, Pocket Hospital and Cloud Hospital, develop Internet hospitals, and promote online registration of birth. Based on residents’ electronic health records, integrate residents’ health management and medical information resources, and carry out electronic health information services covering the whole life cycle of prevention, treatment, rehabilitation and health management. Vigorously promote mobile payment of medical insurance, combine online service hall, mobile APP, WeChat and other means to carry out data integration and information sharing, expand the application of social security cards in the field of medical insurance, and realize medical services such as medical registration, inquiry of electronic medical records and health records, and direct settlement of medical expenses. Promote a healthy lifestyle, encourage residents to activate electronic health records, electronic medical records and other applications, and improve residents’ self-health management ability. (The Provincial Health and Family Planning Commission and the Human Resources and Social Security Department are responsible, and the Provincial Economic and Information Technology Commission and the Bureau of Traditional Chinese Medicine cooperate)
　　(2) Establish a telemedicine application system in an all-round way.
　　Build a telemedicine system connecting the third-class first-class hospitals and county hospitals in eastern, western and northern Guangdong. With county-level hospitals as the hub, a telemedicine network extending to township hospitals, community health service centers and conditional village health stations will be built, and the telemedicine coverage of various medical institutions at all levels will be gradually realized, and telemedicine services such as remote consultation, remote pathological diagnosis, imaging diagnosis, ECG diagnosis, monitoring guidance, surgical guidance and distance education will be carried out. Strengthen the connection of the province’s telemedicine network with other provinces, international academic institutions and well-known foreign medical institutions, and develop inter-provincial and international telemedicine. (Responsible for the Provincial Health and Family Planning Commission, with the cooperation of the Provincial Development and Reform Commission, the Economic and Information Commission, the Department of Finance and the Department of Human Resources and Social Security)
　　Construction of regional pathology, imaging, ECG diagnosis center, further improve the mutual recognition mechanism of inspection results, and realize the interconnection and sharing of inspection results. Formulate telemedicine service prices, medical insurance payment policies and quality management systems to promote the normal operation of telemedicine systems. Promote data resource sharing and business collaboration between high-level hospitals and primary medical and health institutions, general practitioners and specialists. Open up the data channel between health management, disease treatment and rehabilitation, and accelerate the construction of a graded diagnosis and treatment information system based on the Internet and big data technology in accordance with the requirements of "first diagnosis at the grass-roots level, two-way referral, rapid division and treatment, and linkage from top to bottom". (The Provincial Health and Family Planning Commission and the Bureau of Traditional Chinese Medicine are responsible, and the Provincial Development and Reform Commission, the Economic and Information Commission, the Finance Department and the Human Resources and Social Security Department cooperate)
　　(3) Promote the application of health care education and training. Relying on the national health care education and training network, explore the establishment of internet teaching mode and method, and build an open internet health care education system. Integrate online and offline high-quality online education resources, carry out health care popularization education for the public and carry out vocational continuing education for health care practitioners. Encourage higher-level hospitals to establish remote training networks with counterpart hospitals and graded diagnosis and treatment medical institutions, organize remote surgery teaching, and improve the ability of primary medical and health services. Explore the establishment of a general practitioner training model based on the Internet, expand the scale of general practitioner training, and ensure the quality of general practitioner training. Promote the open sharing of health care education resources. (Responsible for the Provincial Health and Family Planning Commission, with the cooperation of the Provincial Development and Reform Commission, the Economic and Information Commission, the Education Department, the Finance Department and the Bureau of Traditional Chinese Medicine)
　　Fifth, improve the health care big data guarantee mechanism

　　(1) Improve laws, regulations and standards. Establish a management system of "graded authorization, classified application and consistent powers and responsibilities", strengthen the standardized management of residents’ health information services, clarify the right to use information, and effectively protect the legitimate rights and interests of all parties. Formulate and improve data management, data and information system security and health data privacy protection systems, and clarify the boundaries, responsible subjects and specific requirements of data collection, transmission, storage, use and opening. Strengthen the protection of information related to national interests, public safety, personal privacy, population genes, etc., and prevent data abuse and privacy disclosure. Follow the national information standards and norms, establish a health care information standards and norms system, and promote the standardization of health care big data products and service processes. Strengthen the evaluation of standard application level and improve the standard application level. (Responsible for the Provincial Health and Family Planning Commission, with the cooperation of the Provincial Development and Reform Commission, the Economic and Information Commission, the Quality Supervision Bureau, the Legislative Affairs Office and the Bureau of Traditional Chinese Medicine)
　　(2) Strengthen the security of health care data. Strengthen the classified management of health care data. The implementation of real-name registration system for residents’ health care services and the use of real-name management for health care data. We will build and improve a unified medical digital identity, electronic real-name authentication and data access control information system for medical and health workers and medical and health institutions in the province, actively promote the application of electronic signatures, and establish a health care data management model with traceable service management, safe operation of diagnosis and treatment data and multi-party cooperation. Adhere to both content security and technical security, and ensure that the regional national health information comprehensive management platform, data exchange network and key information systems are independently controllable, stable and safe. Carry out the reliability, controllability and security evaluation of big data platforms and service providers, as well as the security evaluation and risk assessment of applications, and establish software evaluation and security review systems such as security protection, system interconnection and sharing, and citizen privacy protection. Establish and improve the safety working mechanism of "internet plus Health Care" service, strengthen the safety monitoring and early warning of big data, strengthen the linkage between safety information notification and emergency response, improve the measures to resolve and respond to potential risks, strengthen the protection of important information involving national interests, public safety, patient privacy, business secrets and so on, and strengthen the information security protection of medical schools and scientific research institutions. Strengthen information security protection in cross-border exchanges and cooperation and cooperation between government and social capital. (The Provincial Health and Family Planning Commission is responsible, and the Provincial Development and Reform Commission, the Economic and Information Commission, the Public Security Department, the Human Resources and Social Security Department, the Intellectual Property Office and the Internet Information Office cooperate)
　　(three) to strengthen the construction of health care information compound talent team. Taking "digital doctors" as the training goal, we will formulate the development plan of health care informatization talents and strengthen the discipline construction of medical informatics. Establish and improve the training system of medical informatics talents, focus on cultivating high-level and compound medical information R&D talents and scientific research teams, and cultivate a group of internationally influential medical professionals, academic leaders and industry leaders. Encourage and support institutions of higher learning, health care institutions, industry associations and health care information enterprises to establish educational practice and training bases, closely follow the development needs of the health care big data industry, carry out continuing education and training, and promote the training and team building of health care big data talents. Smooth the career development channel of medical information talents and expand the development space of medical information talents. Orderly promote talent and technology exchanges and cooperation in the development of big data application in health care. (The Provincial Health and Family Planning Commission is responsible, and the Provincial Development and Reform Commission, the Economic and Information Commission, the Education Department, the Finance Department and the Human Resources and Social Security Department cooperate)
　　Sixth, strengthen the organization and implementation

　　(1) Strengthen overall coordination. All localities should establish a working pattern of government leadership, multi-party participation, resource sharing and coordinated promotion. According to the requirements of this implementation opinion, they should put forward the implementation plan of their own regions, clarify specific tasks, and ensure that all measures are implemented. The evaluation results such as the construction of comprehensive management platform for national health information, the maturity of interconnection, the quality of health care data, and the application level of electronic medical records in medical institutions are included in the evaluation of deepening the reform of medical and health system in the province and the evaluation of strong health cities. The Provincial Health and Family Planning Commission should take the lead in establishing a joint conference system to promote and standardize the application and development of big data in health care, strengthen the overall coordination of research and development, new format construction and application promotion of big data technology in health care in the province, and promote the implementation of key tasks. All relevant units should closely cooperate and form a joint force to strengthen support for the development of big data applications in health care. Promote the integrated development of military and civilian health care big data, and promote the standardization, interoperability and collaborative application of military and local health care data. (The municipal people’s government and the provincial health and family planning commission are responsible for all localities, and all relevant units cooperate)
　　(2) Focus on key breakthroughs. All localities should focus on solving the problem of big data application infrastructure construction, accelerate the construction of a comprehensive management platform for national health information at the city and county levels, and accelerate the progress of information system transformation and upgrading of medical and health institutions. Starting from the areas urgently needed by the masses, we will implement the health care big data demonstration project, focusing on promoting the application of big data such as health care, industry governance, clinical medical care and scientific research, public health and traditional Chinese medicine in internet plus. Vigorously support the introduction, digestion, absorption and re-innovation of advanced technologies of health care big data, and focus on developing the health care big data industry chain. Select a number of areas and fields with good basic conditions, high work enthusiasm and guaranteed privacy and security to carry out the pilot application of big data in health care, sum up experience in a timely manner, and make solid and orderly progress. (The Provincial Health and Family Planning Commission and the Finance Department are responsible, and the Provincial Development and Reform Commission, the Economic and Information Commission and the Science and Technology Department cooperate)
　　(3) Increase policy support. Promote the use of government and social capital cooperation (PPP) model to encourage and guide social capital to participate in the infrastructure construction, application development, operation and maintenance services and industrial chain construction of health care big data. Encourage medical and health institutions to cooperate with enterprises, institutions and social institutions, and explore ways to achieve the integration of government applications and social applications in the field of health care big data through government procurement and social crowdsourcing. Encourage innovative diversified investment mechanisms, improve risk prevention and supervision systems, and support the development of health care big data applications. Support qualified health care big data enterprises to go public for financing or issue corporate bonds, connect with multi-level capital markets, and use various financing tools for financing. (The Provincial Health and Family Planning Commission and the Finance Department are responsible, and the Provincial Development and Reform Commission, the Economic and Information Commission, the Science and Technology Department, the Finance Office and the Guangdong Securities Regulatory Bureau cooperate)
　　(4) Strengthen policy propaganda. Strengthen the interpretation of health care big data application development policies, vigorously publicize the significance and application prospects of application development, actively respond to social concerns, and form a good social atmosphere. Actively guide medical and health institutions and social forces to carry out various forms of popular science activities, publicize and popularize the application knowledge of big data in health care, and continuously improve the people’s ability to master relevant applications and health literacy. (The Provincial Health and Family Planning Commission is responsible and all relevant units cooperate)

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General Office of Guangdong Provincial People’s Government

February 8, 2017

Since March 2021, the influenza activity in southern and northern provinces has been higher than that in the same period in 2020, and since September, the level of influenza activity in southern provinces has shown an obvious upward trend. The risk of overlapping epidemic of COVID-19 epidemic and influenza and other respiratory infectious diseases still exists this winter and next spring. Recently, it coincided with a large-scale cooling in China, and the flu vaccine quickly "warmed up". However, how to choose a flu vaccine that suits you?

I. Types of domestic influenza vaccines

At present, there are trivalent inactivated influenza vaccine (IIV3), tetravalent inactivated influenza vaccine (IIV4) and trivalent live attenuated vaccine (LAIV3) approved for marketing in China.

Among them, trivalent influenza vaccine is suitable for children and adults over 6 months, which can prevent influenza caused by two influenza A viruses (H1N1, H3N2) and one influenza B virus (Victoria).

Four-valent influenza vaccine has more protection against one type of influenza B virus (Yamagata) than three-valent influenza vaccine, but the current four-valent influenza vaccine in China needs to be over 3 years old to be vaccinated.

Second, the way of influenza vaccine administration

At present, there are two ways to administer influenza vaccine in China, one is traditional injection and the other is nasal spray.

Among them, the nasal spray method is unique to the nasal spray influenza vaccine, which was only listed in China in August 2020, but it is not the first in China. It has existed abroad for a long time (the United States and the European Union approved the use of nasal spray influenza vaccine in 2003 and 2012, and both of them are tetravalent), but the market share has not been high. This vaccination method can effectively avoid puncture and "needle fainting" caused by injection, but as for whether it can really make children not afraid of getting flu vaccine, it seems that it is not. Although it doesn’t seem to hurt, the nasal mucosa is also very sensitive, and the way of "nasal spray" is not necessarily more comfortable than intramuscular injection. It is difficult for children to ensure the accuracy of vaccination dose, and the technical operation requirements for vaccinators are relatively high.

Third, the safety of influenza vaccine

Influenza-like vaccines are all split or subunit, that is, inactivated vaccines. After years of practice, the safety of all kinds of inactivated vaccines is relatively high. Its contraindications are limited to allergies to vaccine ingredients, and there is no restriction on egg allergies. Even during pregnancy and some elderly people with basic diseases are recommended to be vaccinated.

Then let’s take a look at the new nasal spray influenza vaccine: this vaccine simulates the process of natural influenza infection. After the vaccine is atomized, it enters the body through the nasal cavity, and the first barrier is mucosal immunity, and then cellular immunity and humoral immunity are generated by activating lymphocytes. However, this means that the nasal spray vaccine must be an attenuated live vaccine. From the point of view of safety, attenuated live vaccine may expel vaccine virus strains after inoculation, and occasionally it is reported that the live virus discharged from the vaccinator is transmitted to the uninoculated. Therefore, it is not recommended to vaccinate children with severe immunocompromised patients with nasal spray influenza vaccine.

Relatively speaking, the live attenuated vaccine has more contraindications (rhinitis, asthma, immune problems, etc.), and the range of people who can be vaccinated is narrower. The vaccination age range of this vaccine is 3-17 years old, which directly avoids children under 3 years old and the elderly who may have basic diseases. Pregnancy is also a contraindication. Even people who have used anti-influenza drugs such as oseltamivir and zanamivir (or traditional Chinese medicine with antiviral components) 48 hours before vaccination are not recommended to be vaccinated with this nasal spray vaccine.

Some foreign researchers have summarized the cases of influenza still diagnosed after receiving nasal spray vaccine or attenuated live vaccine or inactivated vaccine for injection. Among 17,173 patients aged 2-17, 4,579 received inactivated vaccine by injection, 1,979 received nasal spray vaccine or live attenuated vaccine, and 10,615 were not vaccinated. It was found that the effectiveness of inactivated vaccine for injection against influenza A (H1N1) was 67%, and the effectiveness of nasal spray vaccine or attenuated live vaccine was 20%. Compared with the recipients of inactivated vaccine by injection, the probability of infection with influenza A (H1N1) is significantly higher among those vaccinated with nasal spray vaccine or live attenuated vaccine.

Fourth, the effectiveness of influenza vaccine

As far as the effectiveness of protection scope is concerned, the tetravalent influenza vaccine containing four influenza virus strains (two types A and two types B) is better than the trivalent influenza vaccine containing three influenza virus strains (two types A and one type B).

Based on five studies from 2013 to 2016, the effect of nasal spray vaccine or live attenuated vaccine on influenza A (H1N1) is lower than that of inactivated vaccine by injection in all children’s age groups. Therefore, the American ACIP (Advisory Committee on Immunization Practice) did not recommend nasal spray influenza vaccine in 2016-2017 and 2017-2018.

A meta-study published online in Pediatrics in January 2019, entitled "Live Attenuated and In Activated Influenza Vaccination Effectiveness", recorded the reasons (and reviewed Meta) why AAP and CDC did not recommend nasal influenza vaccine in 2016-17 and 2017-18.

Please see the figure below for a detailed comparison list.

(Click to view larger image)

Finally, to sum up:Under the age of 3, there is no choice but to get trivalent flu vaccine. Above 3 years old, tetravalent vaccine is definitely the first choice in terms of protection effect. However, the price of trivalent vaccine is half cheaper than that of tetravalent vaccine (50 yuan VS110 yuan). If the money is not bad, then choose tetravalent vaccine. As for the nasal spray vaccine, if you are over 3 years old and under 17 years old, you happen to be "dizzy" or have extreme fear of injection, then it is much better to vaccinate the nasal spray vaccine than to do nothing.

　References:

1.Chung JR, Flannery B, Ambrose CS, Bégué RE, Caspard H, DeMarcus L, Fowlkes AL, Kersellius G, Steffens A, Fry AM; Influenza Clinical Investigation for Children Study Team; Influenza Incidence Surveillance Project; US Influenza Vaccine Effectiveness Network. Live Attenuated and Inactivated Influenza Vaccine Effectiveness. Pediatrics. 2019 Feb; 143(2):e20182094. doi: 10.1542/peds.2018-2094. Epub 2019 Jan 7. PMID: 30617239; PMCID: PMC6361354.

2. Yang Penghui, Yang Lufang. Study on immune defense mechanism of respiratory mucosal infection of influenza virus. International Journal of Immunology, 2006,72(5):294-298.

3. Technical Guide for Influenza Vaccination in China (2020-2021)

4.https://www.cdc.gov/flu/prevent/nasalspray.htm

5 Changchun 100 grams of biological nasal spray attenuated trivalent influenza vaccine instructions