Text/Yangcheng Evening News reporter Zhang Hua correspondent Wu Yuantuan Xu Jianying

　　Why do Chinese medicine practitioners who can keep in good health always make you eat less cold things? Yan Fang, director of the Classic Department of Traditional Chinese Medicine of Guangdong Provincial Hospital of Traditional Chinese Medicine, believes that if we want to be healthy, we must first protect our own yang, because the warmth of the yang makes our body move normally. The biggest harm of cold things lies in the loss of human yang, which leads to the weakening of human function. After the weakening of human visceral function, it is easy to cause stagnation of qi and blood stasis. Many of our diseases come from these bad habits that damage yang.

　　Habit 1 Eat a lot of fruit every day.

　　Fruit is rich in vitamins and dietary fiber, which is good for skin and body. So many women eat a lot of fruit every day, eat watermelon and cut it in half, and dig it with a spoon; Eating a bunch of grapes is like eating melon seeds.

　　Yan Fang, director of the Classic Department of Traditional Chinese Medicine of Guangdong Provincial Hospital of Traditional Chinese Medicine, believes that healthy people should eat 250-400g of fruit every day. Western medicine pays attention to the ingredients of fruit, such as "rich in vitamins", but Chinese medicine pays attention to its properties. However, we often ignore the cold or wet weight of fruits, and the storage and transportation are mostly refrigerated. In addition, our Lingnan area has the characteristics of less mountains and more water, and more cold in the middle soil.

　　Modern people, however, are generally cold because of their love of cold drinks, excessive stress and fatigue, abuse of antibiotics, frequent air conditioning and many other factors. This kind of physique, especially for cold and cold fruits, should be cautious and not eat more. Otherwise, excessive cold and dampness will hurt the spleen and stomach, leading to loss of appetite, loose stool, fear of cold and even eczema.

　　Yan Fang suggested that people who are cold and wet should not eat too much fruit. The ancients paid great attention to this point. They didn’t eat fruit on an empty stomach, the infirm didn’t eat fruit, and children and the elderly didn’t dare to give too much fruit to eat. For patients with deficiency cold and particularly greedy mouth, Yan Fang suggested that when eating fruit, a small amount of boiled water should be used for soaking or boiling, which can slightly reduce the coldness. Knowing your physique, choosing the fruit that suits you and tasting it in moderation are the "health tips" for eating fruit.

　　Habit 2 Drink herbal tea at every turn

　　There are few mountains and low terrain in Lingnan area, which shows that "rustic" is thin. The spleen and stomach belong to the soil, which will inevitably affect the function of the spleen and stomach. In addition, the climate here is hot and humid, and everyone thinks that it is necessary to remove more dampness and heat. Herbal tea can clear fire and quench thirst, and it tastes good. There are herbal tea shops all over the street, and the sales are also good.

　　However, eating too much herbal tea that can clear away heat, detoxify and eliminate dampness will further damage the spleen and stomach. The soil is thin and "the soil does not contain fire", so it is naturally easy to "fire" as a disaster!

　　Yan Fang said that repeated fires are mostly caused by deficiency fire, such as dry mouth and bitter taste, red eyes, oral ulcers, swollen gums, sore throat, nosebleeds, dry stools and so on. At the same time, it is accompanied by symptoms such as dull tongue color, pale lips, thin white or slightly greasy tongue coating, light urine color and smell, dry mouth and no desire to drink more, five upset and hot (hands, feet and heart, collectively called five hearts), insomnia and irritability, so the real cure for fire is to regulate the spleen and stomach. If the "rustic" is thick, it will naturally be difficult to get angry!

　　It is not necessary to put out the fire at the sight of the fire, but to get angry and reduce the fire. Drinking too much herbal tea will hurt Zhongyang, and the health will be damaged the day after tomorrow, causing endless harm. The correct way is that herbal tea should be moderate and lead to fire.

　　Habit 3: I have no time during the day and exercise at night.

　　The pace of work and life in the city is fast, and I really don’t have time to exercise during the day. After work, the night is clean, the weather is cool, running and playing ball games, and I feel very sour and refreshing. Plus, there is another reason to eat supper after exercise. Therefore, many people have no time during the day and are used to doing sports at night.

　　Yan Fang believes that improper exercise is better than no exercise. Night exercise calls the human body’s yang, which is contrary to the natural law of "doing at sunrise and resting at sunset", and even affects sleep and rest at night. In addition, supper will hurt the spleen and stomach.

　　Therefore, Yan Fang does not advocate night exercise, and it is the way to keep fit at sunset.

　　Habit 4 Stay up late and make up during the day.

　　At present, young people are under great work pressure and have many recreational activities. Many people are willing to overdraw their physical strength and consume their blood excessively. For example, they always like to stay up late. Others think that if you stay awake at night, you can make up your sleep time the next day.

　　In fact, staying up late is the most harmful to qi and blood. Therefore, people who stay up late usually look haggard and tend to get old. Chinese medicine believes that what is consumed during the day is the yang of the body, and sleeping at night can make the yang get full rest and nourishment. Staying up late for a long time will disturb the balance of yin and yang, qi and blood in the body. Various organs of the body may have different symptoms.

　　Yan Fang believes that the Tao is to preserve one’s health naturally, to do it at sunrise, to rest at sunset, and to stay up late at night is to call the sun be the spirit. Sleeping during the day is to block the yang, and you are not staying up at night, but living.

　　Habit 5 wash your nose with cold water every day

　　Patients with "allergic rhinitis" are very common, and most of them are allergic and have certain heredity. External stimuli, including cold air, pollen, indoor dust, mites, molds, animal hair, dander and poultry feathers, can all lead to nasal itching, continuous sneezing and a lot of clear water-like serous nasal secretions. Each attack lasts for more than one hour and often recurs.

　　Many people are used to washing their noses, thinking that it can clean the bacteria in the nasal cavity, enhance the resistance of the nasal cavity, strengthen the ventilation and drainage of the sinuses, and promote local blood circulation.

　　However, Yan Fang believes that this will consume the body’s yang, reduce the body’s resistance, take the initiative to induce cold pathogens to invade, and lead to recurrent rhinitis.

　　Experts say that washing the nose with cold water does not cure the symptoms, especially cold water washing the nose adds cold to the cold, which encourages cold pathogens to hide in the house, which is not beneficial but harmful. (Watchmaking/Du Hui)

　　People’s Daily Online, Beijing, May 13 (Yang Xi) Recently, the release of the main data of the seventh national census has aroused great concern from all walks of life. Some netizens found that the trend reflected by the census data published this time is inconsistent with that published in non-census years, so they raised some questions about individual data.

　　In this regard, the National Bureau of Statistics answered the above questions and related questions of population statistics.

　　How to count and publish population data?

　　At present, China’s demographic survey mainly has three ways:

　　The first is the national census, which is conducted once every ten years in the year when the mantissa meets "0", and the census data is published in China Census Data.

　　The second is the national 1% population sampling survey, which was conducted in the year when the mantissa met "5", and the survey data was published in the National 1% Population Sampling Survey Data.

　　Third, the national sample survey of population changes, the sample size accounts for about 1&permil of the total population; In addition to the census year and the sampling year of 1% population survey, it is conducted once a year, and the survey data are published in the Statistical Yearbook of China and the Statistical Yearbook of Population and Employment of China.

　　The main statistical indicators of the above three types of population data will be published in the annual data in the database of the National Bureau of Statistics.

　　Why is the trend reflected by census data inconsistent with that published in non-census years?

　　The population in non-census years is calculated according to the sampling survey data of that year. Due to the missing rate of sampling surveys in some years, there will be some deviations in the estimated population as a whole, and these deviations will continue to accumulate with the passage of time.

　　Carrying out the population census once every 10 years can comprehensively find out the number, structure and distribution of China’s population, let us know more clearly the development of China’s population in the past 10 years, and provide extremely valuable data for better studying population issues and formulating population-related policies.

　　So how to deal with this inconsistency? According to international practice and common practice, after the census, the annual data published between the two censuses are generally revised according to the census results, so as to reflect the population development track more truly and objectively. In the sixth national census and the just-concluded fourth national economic census, historical data were also revised according to census data. At present, this work is in progress, and the relevant data will be released on schedule after the revision is completed.

　　Is the population statistics based on household registration or residence?

　　At present, China’s population census and population survey are counted and summarized according to the resident population. The time standard for judging the permanent population is half a year, and the space standard is township, town and street.

　　The resident population is an important basic data for formulating the national economic and social development plan, evaluating the national economic production capacity, and evaluating the welfare level of residents. It has a wide range of applications, such as financial expenditure, urban construction, housing construction, allocation of public facilities, education investment, medical investment and public utility investment, etc., which need to be planned according to the size of the resident population.

　　The registered population refers to the registered population in a certain area, regardless of whether they go out or not, as long as they register their permanent residence in the public security household registration management department. The data of registered population is counted by the public security department. For a long time, China has established a set of perfect household registration statistics and management system, which has played an important role in social management.

　　How is the floating population data counted?

　　Floating population refers to the population whose residence is inconsistent with the township street where the household registration place is located, and who has been separated from the household registration place for half a year or more (excluding the separation of households within the municipal area). The survey indicators used to judge and reflect the floating population include: the place of registration, the place of residence at the time of investigation, the time of leaving the place of registration and the reasons for leaving the place of registration. The National Bureau of Statistics formulates a demographic survey system according to the Statistics Law of the People’s Republic of China, conducts demographic surveys on a regular basis, and publishes major demographic data such as permanent population, birth population, dead population, urban and rural population and floating population.

　　Line up for spicy food.

　　Tempting Gansu mala Tang.

　　"Bouquets of vegetables" are one after another, and enthusiastic diners are one after another. After Tianshui Mala Tang went out of the circle, this "sky-splashing flow" also began to flock to Lanzhou, and the passenger flow of major Mala Tang shops in the city continued to rise obviously. Embracing this wave of traffic dividends, on March 20th, famous local restaurants in Lanzhou took advantage of the situation to offer a new "Gansu Mala Tang" and add another fire with innovative dishes. Even the University of Science and Technology Beijing, thousands of miles away, issued an official announcement, "The campus canteen window, authentic Tianshui Mala Tang in Gansu, is officially launched"!

　　A Lanzhou hot spicy dip famous store huo Shang Jia huo

　　When visiting Lanzhou, Jin Lan Mala Tang in Anning District must be on the must-eat list.

　　At noon on March 19, looking at the endless diners, Ms. Chen, a citizen of Lanzhou, lamented: "Jin Lan Mala Tang, which is deeply loved on weekdays, has become more popular recently!" This is an old-fashioned Mala Tang shop in Lanzhou. The proprietress’s name is Wen Jinlan, and she is from Longnan, Gansu Province. She has been here for more than 20 years. After the hot spicy dip in Tianshui, more and more diners came here, and sometimes they even had to wait in line for an hour to eat.

　　In order to meet the huge passenger flow, it is normal for Wen Jinlan to get up early for nearly 20 hours every day. The reason why it is popular, in the view of the proprietress Wen Jinlan, is because of "popular taste, everyone likes it". The raw materials such as Gangu pepper, Wudu Dahongpao pepper, vermicelli specially customized from Dingxi and grain vinegar produced nearby have jointly contributed to the mouth-watering "spicy and hot".

　　"A large pot of vegetables, all kinds of ingredients wrapped in red juice, a spoonful of crisp sour radish, and the smell of oily spicy seeds between chopsticks directly hit the taste buds." Every meal, Yanji Mala Tang in Zhengning Road, Chengguan District, all the tables inside and outside the store are full. Many people ask, after more than 30 years of opening, people are so popular that there must be an exclusive secret recipe, right? Mr. Zeng, the boss, said frankly: "My wife and I are out-and-out Jianyang people in Sichuan. We have lived in Lanzhou for decades. We improved and adjusted the proportion of juice according to the tastes of local people, which reduced the hemp degree of pepper. It brings together Gansu local materials such as Dingxi Kuanfen and Gangu Chili, forming a unique flavor of Gansu Mala Tang. "

　　B Lanzhou local catering enterprises innovate dishes.

　　On March 20th, Duanji Hotel in Yantan, Lanzhou officially launched the new dish "Gansu Mala Tang". Yang Guoyan, Chairman of the Folk Food Committee of Longcai Association and Deputy General Manager of Lanzhou Duanji Catering Management Co., Ltd., told Benben News reporter: "In order to meet this wave of traffic, we have developed a new dish close to Tianshui Mala Tang, with ingredients such as Gangu Chili, Dingxi Kuanfen and Qin ‘an Zanthoxylum. As a Longcai hotel, our goal is to create a ‘ Ganwei hot spicy dip ’ The alternative ingredients will be more extensive, adding lily, yak meat and so on. " Yang Guoyan said that many employees in the store are from Tianshui. Through repeated trial production for many days, this new product has been officially launched.

　　"After Tianshui Mala Tang is on fire, how can we seize this wave of traffic and continue to undertake this heat to Lanzhou? In fact, we still have to work hard on product innovation." Yang Guoyan said, "Gansu is more delicious than mala Tang, Wuwei ‘ Three sets of cars ’ , Zhang Ye ‘ Stir-fry firecrackers ’ , Longnan stirred up the group … … Longshang cuisine has a long history. How to make use of this mala Tang craze to make all kinds of snacks in Gansu known to more people and promote them to the whole country requires not only the help of the cultural tourism department, but also the joint efforts of the catering industry and other departments. "

　　C "Gansu Mala Tang" online orders skyrocketed.

　　According to the data of Meituan, since March, the search volume of keywords related to "Gansu Mala Tang" has increased by 18.5 times from last month, and the number of public comments has soared by 13.2 times. The take-away orders of Gansu Mala Tang increased 66 times from last month. Beijing, Xi ‘an, Jinan, Shanghai and Tianjin are the top five cities in search volume.

　　At the same time, the popularity of Tianshui Mala Tang has also driven the growth of local cultural tourism consumption. The booking volume of travel orders in Tianshui City, Gansu Province increased by 71.8% compared with the same period of last year. Among them, the order volume of hotels and homestays increased by 73.6% year-on-year, and the order volume related to scenic spots increased by 216.8% year-on-year. Maijishan Grottoes, Fuxi Temple, Maijishan Hot Springs, Xianrenya and Yuquan Temple are the top five scenic spots in terms of order volume. Shaanxi, Henan, Jiangsu, Guangdong, Ningxia, Beijing and Sichuan are the top provinces and cities in the source of off-site orders.

　　On various social platforms, many netizens called for authentic Gansu Mala Tang to be eaten in their hometown, and called on Tianshui people to open stores in their hometown. Some physical stores that see business opportunities are trying to seize the opportunity … …

　　Gansu Beijing Office, located in Beijing Feitian Mansion, has recently put up "Gansu Mala Tang", attracting many netizens to taste the punch card. And a female shopkeeper from Tianshui also decided to open a Gansu Mala Tang restaurant in Sanlitun, one of the hottest business districts in Beijing, which is expected to be officially opened in half a month.

　　On March 19th, University of Science and Technology Beijing issued a document saying that "Gansu Tianshui Mala Tang" will be launched in the school cafeteria at noon. In order to reflect the authenticity, the school emphasized that "soul juice" is all from Gansu, and it brings together two ingredients of Tianshui, namely Gangu pepper and Qin ‘an pepper. The potato powder is elastic and smooth, Gangu chili pepper is full of oil, and the most delicious thing is the intersection of fresh hemp and Qin ‘an pepper. In fact, as early as 2012, the school established a fixed-point assistance relationship with Qin ‘an County, Gansu Province, and purchased Qin ‘an pepper every year. This year, a new potato powder procurement project was added, and the canteen master went to the local area for research and study, bringing students a better experience.

　　Searching with "Gansu Mala Tang" as the key word through Tianyanchao platform, in the past three months, there have been more than 200 new Mala Tang shops in China. Among them, since February this year, there have been more than 150 newly opened Gansu Mala Tang shops in China. According to the data of Tianyancha Professional Edition, up to now, there are more than 9,600 mala Tang related enterprises in Gansu, while there are nearly 900 related enterprises in Tianshui City alone.

　　Text/Figure Benliu News Lanzhou Morning News reporter Xu Jingwen

Jing Zheng Fa [2018] No.30

District People’s governments, municipal government commissions, offices and bureaus, and municipal institutions:

　　In order to thoroughly implement the Supreme Leader’s Socialism with Chinese characteristics Thought in the New Era and the spirit of the 19th National Congress of the Communist Party of China, fully implement the decision-making arrangements of the CPC Central Committee and the State Council on stabilizing employment, take multiple measures simultaneously and comprehensively, and ensure the smooth completion of the employment objectives and tasks in this city and the sustained and stable employment situation in the current and future period, according to the spirit of "Several Opinions of the State Council on Doing a Good Job in Promoting Employment in the Current and Future Period" (Guo Fa [2018] No.39), combined with the actual situation, the following implementation opinions are put forward:

　　First, support the stable development of enterprises

　　(1) Increase the support for stabilizing posts. Since January 1, 2019, 50% of the unemployment insurance premium actually paid in the previous year can be returned to the insured enterprises that have not laid off employees or laid off fewer employees. From January 1 to December 31, 2019, for the insured enterprises that face temporary production and operation difficulties and are expected to recover, and insist on not laying off employees or reducing layoffs, the return standard can be determined according to the monthly per capita unemployment insurance premium and the number of insured employees in the previous year of this city for six months.

　　(2) Continuously optimize financial services. Improve the policy financing guarantee system, increase the scale of financing guarantee for small and micro enterprises, guide more financial resources to support entrepreneurial employment, and further alleviate the problem of financing difficulties for small and micro enterprises. Banks and other institutions that have made outstanding achievements in the work of business guarantee loans may be rewarded according to 1% of the newly issued business guarantee loans in that year.

　　(3) Guiding and stabilizing labor relations. Strengthen the supervision and management of enterprises’ implementation of the labor contract system and the collective contract system, encourage enterprises to carry out collective consultations with employees, urge enterprises to protect the legitimate rights and interests of employees according to law, further build harmonious labor relations and stabilize employment.

　　Second, encourage entrepreneurship to drive employment

　　(four) increase the support for the discount of business guarantee loans. Small and micro enterprises registered and operated in this city, when the number of newly recruited people who meet the application conditions for business start-up guarantee loans reached 25% of the existing employees (15% for enterprises with more than 100 employees) and signed labor contracts with them for more than one year, can apply for business start-up guarantee loans with a maximum of 3 million yuan according to the standards of the number of recruited people and the amount of each person not exceeding 150,000 yuan, and the discount funds will be borne by the finance. Increase the maximum amount of personal small convenient loans from 100,000 yuan to 150,000 yuan.

　　(5) Strengthen the construction of entrepreneurial carriers. Accelerate the construction of business incubation carriers for key groups and provide low-cost venue support, guidance services and policy support for entrepreneurs; According to the number of entities, the incubation effect and the employment effect, the business incubation base will be rewarded. Support areas with stable employment pressure to provide free business venues for unemployed people to start their own businesses. Strengthen the construction of the "Growth Enterprise Market for College Students" in this city’s regional equity market, and provide professional services such as project incubation, capital docking, equity custody, training and guidance for entrepreneurial enterprises.

　　Third, carry out skills training to improve the quality of employment

　　(six) support enterprises in difficulty to carry out skills training for employees. From January 1 to December 31, 2019, difficult enterprises can use the education funds of enterprise employees to carry out on-the-job training for employees by themselves or by entrusting institutions with corresponding training qualifications in this city. Employees who have obtained corresponding vocational qualification certificates or vocational skill grade certificates after training shall be subsidized by their enterprises according to 50% of the subsidy standard for technical skill upgrading; To carry out non-level skills training and each person’s training time is not less than 20 class hours, and give enterprise subsidies according to the standard of 500 yuan per person.

　　(seven) to encourage workers to improve their professional skills. From January 1, 2019 to December 31, 2020, the application conditions for technical skills upgrading subsidies in this city were relaxed from employees of enterprises who participated in unemployment insurance for more than 3 years to those who participated in insurance for more than 1 year; Persons with employment difficulties in urban and rural areas in this city who have not received unemployment insurance benefits can enjoy cost of living allowance, which is not less than that in 35 yuan, per person per day during the training period, and cost of living allowance policy only enjoys it once per person per year.

　　(eight) to mobilize social forces to participate in vocational training. Support all kinds of vocational colleges (including technical colleges), ordinary colleges and universities, vocational training institutions and qualified enterprises to undertake vocational skills training or entrepreneurship training for unemployed people and rural migrant workers, and give vocational training subsidies according to regulations. The subsidy standard is determined according to the training cost, training duration, market demand and obtaining relevant certificates. Timely study, adjust and enrich the catalogue of vocational training subsidies, and expand the benefits of policies.

　　Fourth, accurate policy to help employment

　　(nine) to expand the scope of employment trainee subsidies. From January 1, 2019, the scope of employment trainee subsidies will be expanded from unemployed college graduates who have left school to registered unemployed people aged 16-24 and rural laborers who have transferred employment registration; Organize them to participate in employment internships for no more than 12 months, give employment internship subsidies according to regulations, and appropriately raise the subsidy standards.

　　(ten) to improve the employer’s post subsidy standards. Employers will be encouraged to recruit people with employment difficulties in urban and rural areas, retired soldiers and laid-off workers from enterprises, and the post subsidy standard will be raised from 5,000 yuan per person per year to 8,000 yuan per person per year.

　　(eleven) to promote the employment of rural labor. Vigorously develop industrial projects with quick results and high returns to help rural laborers find jobs nearby. Encourage outstanding young people to return to their hometowns to start businesses and promote farmers’ employment. Broaden the channels for rural labor to transfer employment, support rural labor who are willing to go out for employment in urban public service posts, and implement relevant policies such as post subsidies and social insurance subsidies. Give full play to the role of rural public welfare posts and enhance the ability to provide care for rural people with employment difficulties.

　　V. Optimizing services to boost employment

　　(twelve) the implementation of permanent service. Unemployed people in this city and rural laborers who require the transfer of employment can apply for unemployment registration, transfer of employment registration and other businesses in the social security offices in the streets (towns) of their permanent residence, enjoy employment and entrepreneurship services nearby, and apply for employment and entrepreneurship support policies at the municipal level and in the districts where their permanent residence is located. People with employment difficulties in urban and rural areas can receive employment assistance in their permanent residence.

　　(13) Improve service quality. Actively use the "internet plus" model, build a network service platform for employment and entrepreneurship, promote departmental information sharing, streamline work links, and reduce application materials, so that "information runs more and people run less errands". Actively carry out policy propaganda, announce the policy list, bidding process, subsidy standard, service organization and contact information, supervise the complaint telephone number to the society, go deep into enterprises to preach policies, understand difficulties, solve problems, do a good job of helping, and promote the implementation of various employment policies and services.

　　(fourteen) to ensure the basic livelihood of the people in need. We will fully implement the unemployment insurance system and steadily raise the level of unemployment insurance benefits. A temporary living allowance of 3,000 yuan will be given to registered unemployed people who have difficulties in life and do not meet the conditions for receiving unemployment insurance benefits. We will integrate urban subsistence allowances, rural subsistence allowances, and low-income family identification systems, expand the scope of assistance, lower the threshold for assistance, and timely include families that meet the minimum living guarantee conditions into the minimum living guarantee scope. Improve the city’s temporary assistance system, give temporary assistance to qualified personnel, and help people in need to get out of trouble.

　　Sixth, improve the safeguard mechanism

　　(15) Strengthen organizational leadership. Give full play to the role of the municipal social security and employment work leading group, improve the working mechanism, and make overall plans for the analysis, policy formulation, guidance and inspection of the city’s employment situation. The relevant municipal departments and district governments should earnestly assume the main responsibility of promoting employment, strengthen communication and close cooperation, and do their best to promote employment.

　　(sixteen) to strengthen publicity and guidance. Guide enterprises to stabilize employees’ employment through transformation, training and job transfer, and support "double innovation"; Guide workers to establish a correct concept of employment, actively improve their employment skills, and realize employment and entrepreneurship through their own efforts. It is necessary to mobilize the forces of all sectors of society to form a joint force to promote employment.

　　(seventeen) optimize the financial security. Comprehensively sort out the existing capital projects that guarantee basic living, promote employment and stabilize employment, and on the basis of maintaining policy continuity and stability, merge and simplify the capital projects and use methods to improve the efficiency of capital use. Strictly implement the real-name management of employment assistance targets and effectively ensure the safe operation of funds.

the people’s government of beijing city

December 20, 2018

BA.4 and BA.5, the new branches of Omicron with stronger communication power, have recently attracted attention. The new branch has triggered a new infection peak in South Africa, and the Portuguese National Institute of Health also estimates that its growth advantage is 13% more than that of BA.2.

Screenshots from the nextstrain website show that the different Omicron branches represented by yellow, orange and red are iterating rapidly within half a year, and the new branches represented by orange and red are also expanding in the cracks.

Screenshot of nextstrain website. According to the uploaded sequencing data, since December last year, the mainstream branches in Omicron have gradually changed from BA.1 (shown as 21K) to BA.2 (shown as 21L) to BA2.12.1 (shown as 22C), and the area occupied by new branches is also expanding.

The new branches of Omicron are frequent. Is the current COVID-19 vaccine still effective? Do the branches BA.2 and BA.5 need their own vaccines? Should the update of COVID-19 vaccine keep up with the variation of virus? How to keep up with the virus mutation? With the above questions, the reporter of Science and Technology Daily contacted and interviewed a number of industry experts.

Is the current vaccine still effective?

Does the mutation branch in Omicron constantly trigger new infection peaks, which means that the current COVID-19 vaccine will be invalid?

Authoritative experts in the industry responded to the Science and Technology Daily reporter and said: "Current vaccines can still provide the most basic protection in ensuring the reduction of severe illness and death.. The epidemic in COVID-19 has been going on for two and a half years. At present, it seems that there is no possibility for Covid-19 to achieve zero infection through vaccination. COVID-19 vaccine can ensure the effect of reducing infection and avoiding serious illness and death. "

Regarding the role of the current vaccine in epidemic prevention and control, the person in charge of vaccine-related production enterprises in COVID-19 holds the same view: "The existing vaccine is no problem in preventing severe illness and death at present, but it will not be 100% anti-infection."

Many statistics or research results from the real world show that the current vaccine plays a significant role in preventing severe illness and death. For example, the latest data in Hong Kong (as of May 25th) showed that the mortality rate of those infected in Omicron who were not vaccinated was 3.04%, while the mortality rate of those infected with three doses of vaccine dropped significantly to 0.04%.

Do the branches BA.2 and BA.5 all need their own vaccines?

According to WHO’s latest weekly report on epidemiological progress in COVID-19 (May 25th),Omicron BA.2 and its progeny pedigree (BA.2.X) have become the main popular variants in the world.At present, the relative proportions of BA.2.X, BA.4 and BA.5 are 94%, 0.8% and 1% respectively.

This shows that during the evolution of Omicron mutant, the branch BA.1 is disappearing. However, the reporter learned that at present, most vaccines against Omicron in China are designed and developed for BA.1.

Whether it is necessary to develop new vaccines for new branches, the industry generally judges from the perspective of vaccine protection: if the activity of neutralizing antibodies produced by the original vaccines against mutant strains is greatly reduced, it is necessary to develop new vaccines; If it still has a good neutralizing effect on the mutant, there is no need to develop a new vaccine.

Although Omicron strain mutates rapidly and different branches appear, butNew vaccines will not be introduced for each branch, and there is no need to do so.. Relevant experts reminded: "If you continue to monitor, you will find that many mutations will disappear soon."

Can vaccine update keep up with virus iteration?

In the technical route of vaccine development in COVID-19, the design cycle of mRNA vaccine is short. On the basis of a mature platform, the design can be completed within 7 days, and the preclinical trials including animal experiments can be completed in about one month.

Industry experts engaged in the research and development of mRNA vaccine said that for the variant branch, the mRNA vaccine does not need to obtain the strain, but only needs to optimize the vaccine sequence according to the variant sequence and test the expression efficiency, and then pre-clinical trials can be carried out. Covid-19 Omicron mutant mRNA vaccine, developed by Suzhou Aibo Bio, China, has been approved for clinical research in UAE.

In response to virus variation, the technical route of inactivated vaccine can also complete the preclinical study of new strains in a short time by establishing an emergency system. The reporter previously learned that it can be advanced to the clinical trial application stage about 2 months after obtaining the new strain.

Keep up with the variation, can COVID-19’s vaccine market learn from the "flu model"

In order to cope with the frequent mutation of viruses, there are precedents for vaccine updates to follow closely. For example, the influenza virus vaccine is recommended by WHO every year, and countries produce new influenza vaccines accordingly.

In order to keep up with the variation in Covid-19, can the "flu model" be used for reference in the marketing of vaccines in COVID-19?

“It is estimated that the future development of COVID-19 vaccine needs to adopt the influenza model.The authoritative experts mentioned above responded, but WHO is unable to recommend mainstream strains through monitoring now, because the pandemic is not over yet.

Another advantage of the "flu model" is that it greatly shortens the time to market for new vaccines. Because there is no need for re-approval, its batch issuance system can effectively shorten the period from vaccine development to marketing. Experts in the industry said that after polishing and construction, various technical routes and platforms have gradually matured, the research and development speed has been accelerated, and the production process has been stable.If the "flu model" can be adopted in the development and marketing of vaccines in COVID-19, the time to market for new vaccines will be greatly shortened.

WHO has revealed some unexpected phenomena in its weekly epidemiological report: available data show that BA.4, BA.5 and BA.2.12.1 spread faster in countries where BA.1 was once prevalent, but less in countries where BA.2 was prevalent; The vaccination degree of each country may have an impact on the popularity of the new branch of Omicron. Visible,Covid-19 mutation and vaccine immunogenicity are mutually causal and widely related, and updating the vaccine in time may have an impact on virus mutation.

Source: Science and Technology Daily

Original title: "Omicron iterates fast, is it necessary to be" anxious "about the vaccine? 》

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1905 movie network news　Last weekend (01.18-01.20), the box office revenue in North America totaled $129 million, up 8.2% from the previous week. Monday is Martin Luther King Memorial Day, and we will continue to have a holiday. Among the new films on the list, M Knight Shamalan’s new film "Mr. Glass" earned $40.58 million in the first three days of the first weekend, which was close to $40.01 million in the first week of "Split" in 2017 and higher than $30.33 million in the first week of "Never Die" in 2000. Not surprised or pleased. The media mostly think that the content is too full and too anxious, but there is no emotional touch. They think that they are not attracted to fans of "The Dead Robber" or "Split" and become ungrateful at both ends. Another new film is a slightly niche animated film "Dragon Ball Super: brolly". The plot is based on the animated series "Dragon Ball". After telling the story of Wukong and brolly, it is biased towards fans. In the first week, it won 10.65 million US dollars in 1233 theaters in North America, but it attracted a limited audience and was not optimistic about its subsequent box office development.

"Mr. Glass" is too full of word of mouth, and the fans of "Dragon Ball Super: brolly" are serious

Recommended star rating of Mr. Glass: ★★★

"Dragon Ball Super: brolly" Recommended star rating: ★★★ (specific fan direction)

On the weekend of Martin Luther King’s Day, M Knight Shamalan’s new work "Mr. Glass" earned 40.58 million US dollars at the box office in North America from Friday to Sunday, which was close to 40.01 million US dollars in the first week of "Split" in 2017 and higher than 30.33 million US dollars in the first week of "Never Die" in 2000. In all the Martin Luther King Memorial Weekends, this box office ranked third, only behind the $41 million of "Sasaki Brothers" in 2014 and the $89 million of "American Sniper" in 2015. The production cost of Mr. Glass is $20 million, and the global box office has reached $90 million. These figures undoubtedly prove Shamalan’s ability to make money again. In fact, even in the low tide of Shamalan’s poor reputation, many of his films were very profitable. For example, in 2008, the production cost of "Death" was 48 million US dollars, and the final global box office was 163 million US dollars. In 2004, the production cost of "Mystery Village" was 60 million US dollars, and the final global box office was 256 million US dollars. What he really didn’t earn was only.

At present, the cinema score of Mr. Glass is B, IMDb score is 7.2, MTC score is 42, and the freshness of rotten tomatoes is 36%. "Hollywood Reporter" commented: "As the final part of the trilogy, this film is like a mixed bag, twisting all the previous narrative clues into one, but unfortunately trying too hard to tell the audience that Shamalan has a very special idea on the popular comic adaptation story, but the result is not shown." "Variety" said: "It’s still very happy to see Shamalan return, but" Mr. Glass "takes up more of our time, but it can’t create any touches, which makes people feel busy and dazzling, but there are few moving moments of emotional resonance." "International Screen" thinks: "Apart from McEvoy’s performance as a smoke bomb and Bruce Willis’s convincing charm, the whole film has actually not gone far in the concept of’ what happens when people become superheroes’." Due to the poor reputation, the follow-up box office track of Mr. Glass may be more similar to the Clover Files, which was opened on the weekend of Martin Luther King’s Day in 2008. The film earned $40 million in the first week and $80 million in the local box office.

Another noteworthy new film last weekend was the classic IP cartoon "Dragon Ball Super: brolly", which was only opened in 1,233 theaters in North America, aiming at clearly attracting a specific fan base, and won $10.65 million at the box office in three days in the first weekend. The story of "Dragon Ball Super: brolly" is a continuation of the upcoming TV animation "Dragon Ball", which tells the story between Saiyan brolly and Wukong. The film was nominated for the best cartoon in the 42nd Japanese Film Academy Award and was very popular among fans. At present, the media scores and fans’ scores of all platforms are very high, with IMDb score of 8.6, MTC score of 64 and the freshness of rotten tomatoes of 80%. The Los Angeles Times said: "brolly is ready to give Dragon Ball fans everything they want in a movie, and other viewers may feel lost in this world." Midwest Film Journal also thinks: "For the novice Dragon Ball, this film provides a dazzling animation time." There are also some media that don’t like it, such as "Movie Country", which means: "This is a meaningless garbage culture animation only for fans."

Old movies: "Neptune" local over 300 million "Upward" has a strong box office stamina.

Warner Bros.’ s superhero movie Neptune has entered its fifth week. After the weekend, the film’s box office outside North Captain America: Civil War has reached 759 million US dollars, surpassing’s 745 million US dollars, and the local box office has also exceeded 300 million US dollars. At present, the film’s global total box office is 1.063 billion US dollars, which is still 3 million US dollars short. Amber Heard’s Neptune can surpass Johnny Depp’s highest-grossing Pirates of the Caribbean: The Coffin. At the same time, Aquaman is also the movie with the strongest box office stamina after Teenage Mutant Ninja Turtles: The Age of Mutations in 2014. It is expected that Aquaman will have a good room for growth before The Lego Movie 2: The Second Part and Listen to Men’s Hearts come out on February 8.

In the following week, Upward Bound kept quite steady, with the box office of $15.6 million in three days over the weekend, which was only 23% lower than that in the first week. Earlier, many films in kevin hart fought bravely in Martin Luther King’s weekend, such as the above-mentioned Sasaki Brothers, Customized Best Man and Sasaki Brothers 2, and so on. This time, Upward Bound was opened in this schedule one week ahead of schedule. At present, the total box office of Upward is US$ 43.98 million. As long as it exceeds the US$ 48.7 million of Supersize Beauty last year, it will become the third domestic box office of STX Entertainment after bad mother and Christmas of Bad Mom. Sony’s Spider-Man: Into the Spider-Verse currently has a global box office of US$ 322 million, which has surpassed The LEGO Batman Movie’s US$ 311 million. The production cost of Spider-Man is US$ 90 million.

This week’s preview: Adventure "King Boy" Playing through the thriller "Quiet" arouses expectations.

This weekend (01.25-01.27), Fox’s youth movie "King Boy" and Matthew McConaughey and Anne Hathaway’s crime thriller "Quiet" will be widely opened in North America.

Fox’s "The King’s Boy" tells the story of a little fat boy, Alex, who accidentally pulls out and passes on the "sword in the stone" mentioned by H. As a destined little hero, he needs to unite his friends and the legendary wizard Merlin to fight against the eccentric witch Morgana. This is a story from modern times to legend, which will be opened in more than 3,400 theaters in North America this Friday. The crime thriller "Quiet" starring Matthew McConaughey and Anne Hathaway was postponed from last October to this week. It tells the story that Baker Dill, the captain of a fishing boat, received a request from his ex-wife Karen to help her kill her violent current husband. Karen’s appearance was forgotten in Jandyr, but in fact, the current situation is also city by the sea. The film will open in more than 2500 theaters this Friday.

10moon17The 9th china international forum on work safety Fire Safety Sub-forum, hosted by the Fire Rescue Bureau of the Ministry of Emergency Management and undertaken by the China Fire Protection Association, was held in Hangzhou, Zhejiang. Experts and scholars from domestic and foreign fire protection fields had in-depth exchanges around "strengthening fire accident prevention and promoting the development of fire protection". Zhou Tian, Chief Engineer of Fire Rescue Bureau of Emergency Management Department, presided over the sub-forum, and Chen Weiming, President of China Fire Protection Association, attended and delivered a speech. Responsible persons of fire departments of fire brigades, responsible persons of fire research institutes and fire product conformity assessment centers, as well as representatives of relevant scientific research institutions, research institutions and enterprises.300More than 200 people attended the sub-forum, and at the same time, the Japanese Fire Protection Association, national fire protection association, the International Federation of Fire Protection Associations and German were invited.VDSExperts and scholars of certification bodies.

Zhou Tian said that this forum is the first large-scale international forum held after the establishment of the Emergency Management Department. During this period, a sub-forum on fire safety was established for the first time, which fully reflected the concern and attention of the Emergency Management Department to the fire-fighting cause and the integration and docking of fire-fighting work and safety production work.

Chen Weiming said in his speech that as the organizer of this china international forum on work safety fire safety sub-forum, it is very meaningful for China Fire Protection Association to provide a high-standard communication platform for fire professionals from all corners of the country.

This sub-forum on fire safety invited domestic fire departments, scientific research institutes, universities, fire-fighting enterprises and fire-fighting experts and scholars from overseas to hold.14The keynote speech included not only the latest achievements in fire risk analysis and prevention and control technology research of high-rise and underground buildings, petrochemical enterprises, large-scale urban complexes and new energy vehicles, but also smart fire protection construction, external wall insulation materials, fire accident investigation, volunteer fire brigade management and certification of domestic fire protection products entering overseas markets, which are all hot, difficult and focus issues in current fire safety work.

Participants in the sub-forum said that it is very rare for Chinese and foreign counterparts to have such an exchange opportunity. Through one day’s discussion and exchange, they not only enhanced mutual understanding, but also enhanced cooperation and friendship, and gained a lot.

CCTV News:During the harvest season, many new farmers are active in the vast fields. They are using newer ideas, better technology and more scientific management mode to change the traditional agricultural planting methods and harvest their own "bumper life".

PPT will be put on first in the meeting. Data and flow are high-frequency words that pop up from time to time in the discussion. You may not think that this group of young people with an average age of less than 29 are actually dealing with land every day.

Li Ting is the head of this team. After graduating from Jiangxi Agricultural University in 2015, she went to an eco-agricultural company in Guangdong. At the end of 2016, Li Ting resigned and returned to his hometown Yingshang County, Anhui Province to start a business.

Compared with the traditional farmers facing the loess and facing the sky, Li Ting’s team is labeled as a "new farmer". The 11 members are all university graduates, including those who study agriculture, finance and journalism. In Li Ting’s view, their advantage lies in making good use of data to guide farming.

Data becomes new agricultural materials to help traditional agricultural production

Then, how did Li Ting and his team apply the new agricultural material "data" to farming? Let’s continue to read the report.

The cycle of crop growth, the change of market conditions, the performance of sales terminals and the portrait of customer groups are as important to Li Ting and his team as seeds, fertilizers and pesticides. At present, this 200-acre spinach is just the harvest that Li Ting and others "grabbed" with data. Before, because of the continuous high temperature, the sprouting rate of edamame was not good even after two crops were planted in the field, and it was about to be harvested.

In order to make good use of data, a new agricultural resource, Li Ting has set the development direction of "market-oriented, order-based planting". Although the planting structure of seedlings of pepper, chestnut pumpkin, Trichosanthes kirilowii and cauliflower has been adjusted, it can ensure that all the seedlings are "explosive". There are jobs in the greenhouse all year round, and more than 60 villagers have a relatively stable job.

The action of "two strengths and one increase" helps new farmers "wisdom" to cultivate land

In order to further improve the efficiency of vegetable planting, Li Ting and others are going to upgrade the previous greenhouse, but the upfront investment in facility agriculture is very large, and the cost of upgrading the digital greenhouse is even higher. How did they solve the problem of funds?

Just when Li Ting’s team was at a loss for funds, Anhui Province launched the action of "strengthening agriculture by science and technology, strengthening agriculture by machinery and increasing farmers’ income", providing a series of policies and financial support for digital agriculture projects.

With the support of various policies and funds of the local government, Li Ting’s base has gradually established a digital seedling factory, a cold storage room, a movable seedbed, an automatic sprinkler system and a visual Internet of Things system. These "new farm tools" exchanged for real money have made farming more scientific and technological and easier.

Just last year, Li Ting became a science and technology correspondent in Yingshang County, and his base has also become a local exhibition area for promoting modern agriculture. Almost every week, people come to visit and study.

Digitalization empowers new farmers to become farmers.

Li Ting and his friends have used what they have learned to become new farmers, realizing their own value and driving more and more people around them.

At present, the planting base of Li Ting has grown to 560 mu, and the surrounding planting area is 3,000 mu driven by radiation. Everyone knows that following Li Ting, there is no need to sell vegetables.

In the past two years, in addition to the flourishing facilities vegetable project, Li Ting and his team have successively transferred more than 2,000 mu of cultivated land, planting staple foods such as rice and wheat. Growing vegetables and raising seedlings, they already have rich experience and stable sales channels. Why should they go out of the comfort zone? Li Ting’s goal in mind is not small.

Li Ting, head of Anhui Yingshang Shili Ecological Agriculture Technology Co., Ltd.:We do field crops mainly based on the consideration of "digital" farmland, and we want to digitally empower in the field. At the same time, there is no need to panic when we have food in our hands, and the issue of national food security is also our responsibility as a new farmer.

Since March 2021, the influenza activity in southern and northern provinces has been higher than that in the same period in 2020, and since September, the level of influenza activity in southern provinces has shown an obvious upward trend. The risk of overlapping epidemic of COVID-19 epidemic and influenza and other respiratory infectious diseases still exists this winter and next spring. Recently, it coincided with a large-scale cooling in China, and the flu vaccine quickly "warmed up". However, how to choose a flu vaccine that suits you?

I. Types of domestic influenza vaccines

At present, there are trivalent inactivated influenza vaccine (IIV3), tetravalent inactivated influenza vaccine (IIV4) and trivalent live attenuated vaccine (LAIV3) approved for marketing in China.

Among them, trivalent influenza vaccine is suitable for children and adults over 6 months, which can prevent influenza caused by two influenza A viruses (H1N1, H3N2) and one influenza B virus (Victoria).

Four-valent influenza vaccine has more protection against one type of influenza B virus (Yamagata) than three-valent influenza vaccine, but the current four-valent influenza vaccine in China needs to be over 3 years old to be vaccinated.

Second, the way of influenza vaccine administration

At present, there are two ways to administer influenza vaccine in China, one is traditional injection and the other is nasal spray.

Among them, the nasal spray method is unique to the nasal spray influenza vaccine, which was only listed in China in August 2020, but it is not the first in China. It has existed abroad for a long time (the United States and the European Union approved the use of nasal spray influenza vaccine in 2003 and 2012, and both of them are tetravalent), but the market share has not been high. This vaccination method can effectively avoid puncture and "needle fainting" caused by injection, but as for whether it can really make children not afraid of getting flu vaccine, it seems that it is not. Although it doesn’t seem to hurt, the nasal mucosa is also very sensitive, and the way of "nasal spray" is not necessarily more comfortable than intramuscular injection. It is difficult for children to ensure the accuracy of vaccination dose, and the technical operation requirements for vaccinators are relatively high.

Third, the safety of influenza vaccine

Influenza-like vaccines are all split or subunit, that is, inactivated vaccines. After years of practice, the safety of all kinds of inactivated vaccines is relatively high. Its contraindications are limited to allergies to vaccine ingredients, and there is no restriction on egg allergies. Even during pregnancy and some elderly people with basic diseases are recommended to be vaccinated.

Then let’s take a look at the new nasal spray influenza vaccine: this vaccine simulates the process of natural influenza infection. After the vaccine is atomized, it enters the body through the nasal cavity, and the first barrier is mucosal immunity, and then cellular immunity and humoral immunity are generated by activating lymphocytes. However, this means that the nasal spray vaccine must be an attenuated live vaccine. From the point of view of safety, attenuated live vaccine may expel vaccine virus strains after inoculation, and occasionally it is reported that the live virus discharged from the vaccinator is transmitted to the uninoculated. Therefore, it is not recommended to vaccinate children with severe immunocompromised patients with nasal spray influenza vaccine.

Relatively speaking, the live attenuated vaccine has more contraindications (rhinitis, asthma, immune problems, etc.), and the range of people who can be vaccinated is narrower. The vaccination age range of this vaccine is 3-17 years old, which directly avoids children under 3 years old and the elderly who may have basic diseases. Pregnancy is also a contraindication. Even people who have used anti-influenza drugs such as oseltamivir and zanamivir (or traditional Chinese medicine with antiviral components) 48 hours before vaccination are not recommended to be vaccinated with this nasal spray vaccine.

Some foreign researchers have summarized the cases of influenza still diagnosed after receiving nasal spray vaccine or attenuated live vaccine or inactivated vaccine for injection. Among 17,173 patients aged 2-17, 4,579 received inactivated vaccine by injection, 1,979 received nasal spray vaccine or live attenuated vaccine, and 10,615 were not vaccinated. It was found that the effectiveness of inactivated vaccine for injection against influenza A (H1N1) was 67%, and the effectiveness of nasal spray vaccine or attenuated live vaccine was 20%. Compared with the recipients of inactivated vaccine by injection, the probability of infection with influenza A (H1N1) is significantly higher among those vaccinated with nasal spray vaccine or live attenuated vaccine.

Fourth, the effectiveness of influenza vaccine

As far as the effectiveness of protection scope is concerned, the tetravalent influenza vaccine containing four influenza virus strains (two types A and two types B) is better than the trivalent influenza vaccine containing three influenza virus strains (two types A and one type B).

Based on five studies from 2013 to 2016, the effect of nasal spray vaccine or live attenuated vaccine on influenza A (H1N1) is lower than that of inactivated vaccine by injection in all children’s age groups. Therefore, the American ACIP (Advisory Committee on Immunization Practice) did not recommend nasal spray influenza vaccine in 2016-2017 and 2017-2018.

A meta-study published online in Pediatrics in January 2019, entitled "Live Attenuated and In Activated Influenza Vaccination Effectiveness", recorded the reasons (and reviewed Meta) why AAP and CDC did not recommend nasal influenza vaccine in 2016-17 and 2017-18.

Please see the figure below for a detailed comparison list.

(Click to view larger image)

Finally, to sum up:Under the age of 3, there is no choice but to get trivalent flu vaccine. Above 3 years old, tetravalent vaccine is definitely the first choice in terms of protection effect. However, the price of trivalent vaccine is half cheaper than that of tetravalent vaccine (50 yuan VS110 yuan). If the money is not bad, then choose tetravalent vaccine. As for the nasal spray vaccine, if you are over 3 years old and under 17 years old, you happen to be "dizzy" or have extreme fear of injection, then it is much better to vaccinate the nasal spray vaccine than to do nothing.

　References:

1.Chung JR, Flannery B, Ambrose CS, Bégué RE, Caspard H, DeMarcus L, Fowlkes AL, Kersellius G, Steffens A, Fry AM; Influenza Clinical Investigation for Children Study Team; Influenza Incidence Surveillance Project; US Influenza Vaccine Effectiveness Network. Live Attenuated and Inactivated Influenza Vaccine Effectiveness. Pediatrics. 2019 Feb; 143(2):e20182094. doi: 10.1542/peds.2018-2094. Epub 2019 Jan 7. PMID: 30617239; PMCID: PMC6361354.

2. Yang Penghui, Yang Lufang. Study on immune defense mechanism of respiratory mucosal infection of influenza virus. International Journal of Immunology, 2006,72(5):294-298.

3. Technical Guide for Influenza Vaccination in China (2020-2021)

4.https://www.cdc.gov/flu/prevent/nasalspray.htm

5 Changchun 100 grams of biological nasal spray attenuated trivalent influenza vaccine instructions

North America is the largest film market in the world, and it is also the main battlefield to test the success or failure of a Hollywood film. Generally speaking, there are two institutions that regularly publish box office data of North American film market: the website Box Office Mojo mainly collects and counts the data reported by publishers themselves; Comscore, a media company specializing in collecting and analyzing all kinds of data, collects daily box office data from the cinema, which is also the main source of box office data for American media.

Traditionally, Comscore’s annual report will not be released until the first Tuesday of the new year, that is, January 2, 2024, local time in the United States, but it is said that the total box office in North America will basically fall between $9.03 billion and $9.05 billion in 2023. As for Box Office Mojo, because of the time difference, the North American box office figure in 2023 on this website is still at $8.905499 billion for the time being, but I believe it will be further updated in a few days.

"Baben Harmo"

Looking back on the key words of North American movies in 2023, the first one was "Baben Harmo": two commercial blockbusters with irrelevant contents and types collided head-on in the same schedule, and the result was not that they changed, but that they successfully ignited the audience’s enthusiasm together and became a phenomenal movie event in 2023. Barbie, produced by Warner Bros. Film Company, finally became the North American box office champion in 2023 with a score of $636 million, while Oppenheimer, produced by Universal Pictures, ranked fifth in the annual box office list in North America with $326 million.

The success of the two works has its own reasons, but to sum up, it is nothing more than abandoning the routine and highlighting the new ideas. Together with Universal Pictures’ Super Mario Bros. Movie, which ranked second in North America’s annual box office list with US$ 574 million, these three works can be said to have high original value.

Although Barbie comes from a world-famous popular toy, Super Mario Bros. Movie is based on a well-known video game of the same name, and the protagonist of Oppenheimer has already gone down in history because of the atomic bomb, they are not actually sequel to the movie or remakes of old movies, which can attract the audience to buy tickets and rely on real original stories and designs.

Stills of Super Mario Bros. Movie

In sharp contrast, in 2023, a lot of blockbusters failed at the box office, almost all sequels and series of works. In addition to the superhero movies that have completely tired the audience aesthetically, Raiders of the Lost Ark 5 and Mission Impossible 7 have also failed to achieve satisfactory box office results.

The total box office in North America in 2023 is definitely the highest in North America since the epidemic subverted the film industry, far better than the $7.46 billion in 2022 and $4.56 billion in 2021. However, such achievements have not returned to the level before the epidemic.

Historically, the box office in North America has steadily exceeded $10 billion every year since 2009, and since 2015, this figure has exceeded $11 billion every year. Before the epidemic, in 2019, although the box office performance of North American movies has been severely squeezed by the streaming media market, the box office of the whole year can still easily reach 11.4 billion US dollars.

On the surface, it seems that the main reason is that the number of films released by Hollywood studios is getting smaller and smaller every year: only 88 films were released on a large scale in 2023, while in 2019, the box office reached 10.5 billion US dollars, which was 108, a full 20 more. However, I really want to say, even if there are 20 more new films in 2023, will it be guaranteed that the box office will increase by 2 billion US dollars? Who can say that these 20 films will get an average of $100 million at the North American box office each?

Movies like Barbie and Oppenheimer can persuade people to pay for tickets because they can only appreciate the beauty of light and shadow when they are watched on the big screen, and the same is true for Taylor Swift: Time Tour Concert, which became a dark horse at the box office near the end of the year. In 2023, when the streaming media service is becoming more and more mature (and saturated), how many movies must be experienced in the cinema in the eyes of the audience? Below, we will look at it according to the winners and losers list of the five major Hollywood manufacturers.

Universal Pictures International

Wins: Super Mario Bros. Movie ($575 million), Oppenheimer ($326 million), Five Nights of the Teddy Bear ($137 million) and Megan ($95 million).

Negative: Speed and Fury 10 ($146 million), Renfield ($17 million), Demeter’s Last Voyage ($13 million).

According to film companies, Universal Pictures, which won $1.93 billion in 2023, topped the North American box office list. With the blockbuster films such as Super Mario Bros. Movie and Oppenheimer, Universal has occupied about 22% of the box office share in North America, slightly overwhelming Disney and winning the first prize since 2015.

Oppenheimer stills

In 2023, Universal occupied two seats in the top five most popular films in North America. In addition, the innovative thriller Megan, which cost only $12 million, also earned nearly $100 million at the box office, while Five Nights of the Teddy Bear turned the cost of $20 million into a box office of $137 million, making them the two most cost-effective movies in 2023.

Of course, Universal also made some mistakes in 2023, and the tenth The Fast and the Furious series was exhausted, but the production cost was getting higher and higher, reaching a shocking $340 million, which erased a lot of the annual bonus of Universal.

In 2024, Kung fu panda 4’s "Daddy Thief 4" and other works will be listed around the world, and there is still a chance to win the championship again.

Disney

Wins: Galaxy Guard 3 ($359 million), The Little Mermaid ($297 million), Crazy Element City ($154 million).

Negative: Captain Surprise 2 ($84 million), Indiana Jones 5 ($174 million), Star Wish ($61 million), Haunted House ($68 million).

2023 is Disney’s centenary birthday, which should have been a year worth celebrating. Various commemorative movies, books and activities were also arranged in advance. However, the overall commercial achievements released at the end of the year made 2023 a year when Mickey Mouse fell to the altar.

Since the annual box office accounted for 26% in 2016, Disney has become the sole overlord of Hollywood in the past few years by relying on its fist products such as Marvel Comics and Pixar; The peak appeared in 2019, accounting for 33.3% of the box office. Seven of the top ten films in the world were produced by Disney, and the box office of each film exceeded $1 billion, leaving the other Hollywood giants completely behind.

However, with the arrival of COVID-19, everything came to an abrupt end. Three years after the epidemic, Disney’s box office share was only 11%, 20% and 18% respectively. However, at that time, Disney’s box office declined because of the external factors of closed cinemas and filming stoppage, which can be said to be a crime of no war. By the end of the epidemic in 2023, Disney’s box office still accounts for only 16%, so you can only find the reason from yourself.

The most serious problem is naturally the continuous downturn of the Marvel movie universe. From "Ant Man 3" at the beginning of the year to "Captain Surprise 2" at the end of the year, all of them lost their eye-catching characteristics in the past, and the latter even became the worst box office in the history of Marvel Comics movies, which made Disney CEO Bob Iger admit that at the previous stage, they really made a big mistake of focusing only on quantity and ignoring quality. At the same time, it also reminds opponents once again that there has never been any panacea in Hollywood, and the tastes of the audience are changing rapidly. Sitting on one’s laurels and standing still is doomed to die.

"Galaxy Guard 3" poster

On the whole, among the top ten box offices in North America, Disney still has the illusion that "Guards of the Galaxy 3" ranks fourth, "The Little Mermaid" ranks sixth and "Ant Man 3" ranks eighth, and there is still the illusion that "the skinny camel is bigger than the horse". However, excluding the special circumstances of the epidemic for three years, this has become the first year since 2014 that Disney has not had any film with a global box office exceeding the $1 billion mark.

Of course, Disney’s advantage is that it has acquired a large number of high-quality assets through mergers in the past few years. After being acquired by Disney, 20th Century Fox, which originally belonged to the ranks of the six Hollywood manufacturers, was renamed 20th Century Pictures, and its box office was also included in the Disney Group’s evaluation. In 2023, they released three works, Cabinet Devil, Venetian fright night and AI Creator. Together with the release of Avatar 2 in early 2023, they earned about $400 million in North American box office. Including this part, Disney accounted for about 21% of the annual box office in North America, ranking second.

Warner Bros.

Wins: Barbie ($636 million), Nun 2 ($86 million), Meg 2 ($82 million), Wonka ($143 million).

Negative: The Flash ($108 million), The Blue Beetle ($72 million), Shazam 2 ($57 million), Aquaman 2 ($85 million).

With Barbie, the highest box office in North America in 2023 (the film also won the annual global box office champion with a box office score of $1.44 billion), Warner failed to become the North American box office champion in 2023, ranking third with only $1.4 billion and a share of about 15.24%. I am afraid that the reason can only be attributed to the poor box office performance of DC superheroes.

"Barbie" stills

In addition to Barbie, in 2023, Warner also tasted a lot of sweetness in the horror film Sister 2 and the family movie Wonka. However, they invested about $660 million in the production cost of the four DC films, The Flash, The Blue Beetle, Shazam 2 and Aquaman 2. As a result, the global box office revenue of the four films was less than that of the 2016 Batman v Superman: Dawn of Justice ($874 million).

In 2024, Warner will publish Dune 2, Godzilla vs. king kong 2, Clown 2 and other works, which hopefully will lead to a comeback.

Sony pictures

Wins: Spider-Man: The Vertical and Horizontal Universe (US$ 381 million) and The Wronger 3 (US$ 92 million).

Negative: Silly Money ($13 million) and Escape from Cretaceous ($32 million).

In 2020, when the world was in chaos, Sony Pictures once became the biggest winner in the North American film market, gaining more than 20% market share. After that, in 2021, they also continued to be in the forefront. However, in 2022, when everything is slightly back on track, Sony’s market share has retreated to the fifth place. In 2023, the situation is slightly better than that of Paramount, which is at the bottom. The annual box office of less than $1 billion accounts for about 11% of the market.

Stills of Spider-Man: The Vertical and Horizontal Universe

During the three years of the epidemic, Sony released about 16 or 17 works every year, and in 2023, it rose to 27, far more than any other Hollywood factory, and basically recovered to the level before the epidemic.

The animated film Spider-Man: The Vertical and Horizontal Universe, which was released in June, is a rare Marvel Comics movie that sold well at the box office in 2023. The global box office of "Grievance 3" also reached $190 million, almost the same as the first two films, showing the high popularity of Denzel Hayes Washington Jr.. As for "Napoleon" released at the end of the year, it is not a box office success in itself. After all, the production cost of the film is as high as 200 million US dollars. However, this huge sum of money basically comes from Apple with deep pockets, and Sony is only responsible for issuing, and the package will not be compensated.

In 2024, as usual, Sony will have a wave of new films such as Ghostbusters: The Frozen City, Garfield, Mrs. Spider: Super Awakening, Kraven the Hunter, Venom 3, etc., and the box office should make a breakthrough.

Paramount

Wins: Scream 6 ($108 million), Wang Wang Team 2 ($65 million), Teenage Ninja Turtles: Mutant Fight ($118 million).

Negative: Mission Impossible 7 ($172 million) and Dungeons and Dragons: The Glory of Grand Theft Auto ($93 million).

2023 is really a year to break the Hollywood convention. Not only has the invincible superhero movies been beaten, but even Tom Cruise, which has always been a box office guarantee, has experienced the existential crisis of Lian Po’s old age.

Before the release of "Mission Impossible 7", almost everyone expected that it would be Tom Cruise’s second successful summer file after "Top Gun 2". As a result, "Mission Impossible 7" failed to ignite the enthusiasm of North American people for watching movies on the first weekend, and was quickly defeated by Barbie and Oppenheimer. The most deadly thing is that the epidemic pushed the production cost of the film up to an astonishing $291 million, which caused it to bear an excessive burden before it was released.

Dungeons and Dragons: Glory of Grand Theft Auto poster

The box office failure of Dungeons and Dragons was also somewhat unexpected. After all, the film was adapted from a powerful game IP, and the audience’s reputation after the screening was very good, but perhaps because of the schedule, there was still a lack of enough audience to join in, which made this $150 million film unable to break even.

In the whole year, Paramount released a total of 10 films, with a box office of just over $800 million, accounting for about 9.6% of the total box office in North America, ranking fifth, far below the market share of 17.6% in 2022 with the blessing of Top Gun 2.

In 2024, Paramount will release some blockbuster new films, such as Gladiator 2, Transformers: The First Generation and Sonik the Hedgehog 3, which is expected to turn the tide.

Taylor Swift: Time Tour Concert Poster

In addition to the above-mentioned five Hollywood giants, Lionsgate Pictures, which took 6.55% of the market share, ranked sixth in the annual box office in North America. They released 12 films in the whole year, and "Fast Chasing 4" ranked ninth in the annual single box office in North America with $187 million. Further back, the independent film "Voice of Freedom", which is not unusual in shooting, distribution and publicity, won $184 million at the box office, which just squeezed into the tenth place in the annual single-chip box office list in North America.

Taylor Swift: Time Tour Concert, with the same maverick distribution model, earned $179 million at the box office, ranking 11th in the annual single-chip box office list in North America. Independent films like this broke into the top of the annual box office list for more than ten years, which seems to reflect the coming of the unprecedented changes in Hollywood in N years.