Omicron iterates fast, can COVID-19 vaccine market learn from the "flu model"

BA.4 and BA.5, the new branches of Omicron with stronger communication power, have recently attracted attention. The new branch has triggered a new infection peak in South Africa, and the Portuguese National Institute of Health also estimates that its growth advantage is 13% more than that of BA.2.

Screenshots from the nextstrain website show that the different Omicron branches represented by yellow, orange and red are iterating rapidly within half a year, and the new branches represented by orange and red are also expanding in the cracks.

Screenshot of nextstrain website. According to the uploaded sequencing data, since December last year, the mainstream branches in Omicron have gradually changed from BA.1 (shown as 21K) to BA.2 (shown as 21L) to BA2.12.1 (shown as 22C), and the area occupied by new branches is also expanding.

The new branches of Omicron are frequent. Is the current COVID-19 vaccine still effective? Do the branches BA.2 and BA.5 need their own vaccines? Should the update of COVID-19 vaccine keep up with the variation of virus? How to keep up with the virus mutation? With the above questions, the reporter of Science and Technology Daily contacted and interviewed a number of industry experts.

Is the current vaccine still effective?

Does the mutation branch in Omicron constantly trigger new infection peaks, which means that the current COVID-19 vaccine will be invalid?

Authoritative experts in the industry responded to the Science and Technology Daily reporter and said: "Current vaccines can still provide the most basic protection in ensuring the reduction of severe illness and death.. The epidemic in COVID-19 has been going on for two and a half years. At present, it seems that there is no possibility for Covid-19 to achieve zero infection through vaccination. COVID-19 vaccine can ensure the effect of reducing infection and avoiding serious illness and death. "

Regarding the role of the current vaccine in epidemic prevention and control, the person in charge of vaccine-related production enterprises in COVID-19 holds the same view: "The existing vaccine is no problem in preventing severe illness and death at present, but it will not be 100% anti-infection."

Many statistics or research results from the real world show that the current vaccine plays a significant role in preventing severe illness and death. For example, the latest data in Hong Kong (as of May 25th) showed that the mortality rate of those infected in Omicron who were not vaccinated was 3.04%, while the mortality rate of those infected with three doses of vaccine dropped significantly to 0.04%.

Do the branches BA.2 and BA.5 all need their own vaccines?

According to WHO’s latest weekly report on epidemiological progress in COVID-19 (May 25th),Omicron BA.2 and its progeny pedigree (BA.2.X) have become the main popular variants in the world.At present, the relative proportions of BA.2.X, BA.4 and BA.5 are 94%, 0.8% and 1% respectively.

This shows that during the evolution of Omicron mutant, the branch BA.1 is disappearing. However, the reporter learned that at present, most vaccines against Omicron in China are designed and developed for BA.1.

Whether it is necessary to develop new vaccines for new branches, the industry generally judges from the perspective of vaccine protection: if the activity of neutralizing antibodies produced by the original vaccines against mutant strains is greatly reduced, it is necessary to develop new vaccines; If it still has a good neutralizing effect on the mutant, there is no need to develop a new vaccine.

Although Omicron strain mutates rapidly and different branches appear, butNew vaccines will not be introduced for each branch, and there is no need to do so.. Relevant experts reminded: "If you continue to monitor, you will find that many mutations will disappear soon."

Can vaccine update keep up with virus iteration?

In the technical route of vaccine development in COVID-19, the design cycle of mRNA vaccine is short. On the basis of a mature platform, the design can be completed within 7 days, and the preclinical trials including animal experiments can be completed in about one month.

Industry experts engaged in the research and development of mRNA vaccine said that for the variant branch, the mRNA vaccine does not need to obtain the strain, but only needs to optimize the vaccine sequence according to the variant sequence and test the expression efficiency, and then pre-clinical trials can be carried out. Covid-19 Omicron mutant mRNA vaccine, developed by Suzhou Aibo Bio, China, has been approved for clinical research in UAE.

In response to virus variation, the technical route of inactivated vaccine can also complete the preclinical study of new strains in a short time by establishing an emergency system. The reporter previously learned that it can be advanced to the clinical trial application stage about 2 months after obtaining the new strain.

Keep up with the variation, can COVID-19’s vaccine market learn from the "flu model"

In order to cope with the frequent mutation of viruses, there are precedents for vaccine updates to follow closely. For example, the influenza virus vaccine is recommended by WHO every year, and countries produce new influenza vaccines accordingly.

In order to keep up with the variation in Covid-19, can the "flu model" be used for reference in the marketing of vaccines in COVID-19?

It is estimated that the future development of COVID-19 vaccine needs to adopt the influenza model.The authoritative experts mentioned above responded, but WHO is unable to recommend mainstream strains through monitoring now, because the pandemic is not over yet.

Another advantage of the "flu model" is that it greatly shortens the time to market for new vaccines. Because there is no need for re-approval, its batch issuance system can effectively shorten the period from vaccine development to marketing. Experts in the industry said that after polishing and construction, various technical routes and platforms have gradually matured, the research and development speed has been accelerated, and the production process has been stable.If the "flu model" can be adopted in the development and marketing of vaccines in COVID-19, the time to market for new vaccines will be greatly shortened.

WHO has revealed some unexpected phenomena in its weekly epidemiological report: available data show that BA.4, BA.5 and BA.2.12.1 spread faster in countries where BA.1 was once prevalent, but less in countries where BA.2 was prevalent; The vaccination degree of each country may have an impact on the popularity of the new branch of Omicron. Visible,Covid-19 mutation and vaccine immunogenicity are mutually causal and widely related, and updating the vaccine in time may have an impact on virus mutation.

Source: Science and Technology Daily

Original title: "Omicron iterates fast, is it necessary to be" anxious "about the vaccine? 》

Read the original text

Notice of the General Office of Beijing Municipal People’s Government on prohibiting the stocking of birds and animals that affect flight safety in the clearance protection area of Capital Internation

Beijing Zhengban Fa [2008] No.1

The people’s governments of the districts and counties, the commissions, offices and bureaus of the municipal government, and the municipal institutions:

  In recent years, the civil aviation planes of Capital International Airport (hereinafter referred to as Capital Airport) have been repeatedly hit by pigeons raised and released in the surrounding areas, especially since 1998, and such incidents have been on the rise, which has seriously endangered the flight safety of civil aviation. With the rapid growth of the flight volume of the Capital Airport and the approaching of the Beijing Olympic Games in 2008, in order to eliminate the hidden danger of bird strikes against aircraft in the clearance protection area of the Capital Airport and ensure the flight safety of civil aviation, according to the Civil Aviation Law of People’s Republic of China (PRC), the Notice of the General Office of the State Council on Strengthening the Management of Civil Aviation Flight Safety (Guo Ban Fa [2004] No.37) and other relevant regulations, with the consent of the municipal government, the relevant matters are hereby notified as follows:

  1. According to the Convention on International Civil Aviation, the national civil aviation industry standard "Technical Standard for Civil Airport Flight Areas" (MH5001-2006) and other relevant regulations, the clearance protection area of the Capital Airport is 35.8 kilometers long from north to south, 15.9 kilometers wide from east to west, and covers an area of about 257.72 square kilometers (see Annex for specific coverage).

  2. In the clearance protection area of the Capital Airport, it is strictly forbidden to raise and fly pigeons and other birds and animals (hereinafter referred to as birds and animals) that affect flight safety. Outside the clearance protection area of the Capital Airport, when flying birds and animals, no unit or individual may fly through the clearance protection area of the Capital Airport.

  3. In the planned land use scope and clearance protection area of the Capital Airport, the industrial and commercial departments shall not register enterprises and individual industrial and commercial households engaged in raising and releasing birds and animals according to law. Within the planned land area of the Capital Airport, if bird activities endangering flight safety occur, the airport management agency shall take eviction or other necessary measures to deal with them. Outside the planned land use scope of the Capital Airport and within the clearance protection area, the local district government is responsible for building dovecotes and raising, flying and operating birds and animals without a license in violation of relevant regulations, and organizes urban management and law enforcement, public security, industry and commerce and other relevant departments, neighborhood offices and township governments to investigate and deal with them according to law.

  Fourth, the carrier pigeon association should do a good job in the organization and management of its members, sheds, clubs, etc., and supervise them to strictly abide by the relevant regulations when raising and flying carrier pigeons and organizing racing competitions, so as not to affect flight safety.

  Five, civil aviation, public security, urban management and law enforcement, industry and commerce departments should earnestly perform their respective duties, and in accordance with the Civil Aviation Law of People’s Republic of China (PRC), the Law of People’s Republic of China (PRC) on Public Security Administration Punishment, the Measures for Investigating and Banning Unlicensed Business (Order No.370 of the State Council), and the Regulations of Beijing Municipality on City Appearance and Environmental Sanitation, etc., the illegal acts shall be punished, and criminal responsibility shall be investigated according to law.

  Attachment: Scope of Clearance Protection Area of Capital Airport

  January 4th, 2008  

Attachment:

Scope of clearance protection area of Capital Airport

  According to the Convention on International Civil Aviation, the national civil aviation industry standard "Technical Standard of Civil Airport Flight Area" (MH5001-2006) and other relevant regulations, the clearance protection area of the Capital Airport is 6 kilometers on both sides of each runway and 15 kilometers at both ends. According to the final planning of the four runways, the clearance protection area of the Capital Airport is 35.8 kilometers long from north to south and 15.9 kilometers wide from east to west, with a total area of about 257.72 square kilometers in the east to Linhe Industrial Zone in Renhe District, Shunyi District, fan village in Yongshun District, Tongzhou District, Luogezhuang Village in Houshayu District, Shunyi District, and Baofang Village in Zhaoquanying Town, Shunyi District. It covers 3 streets, 6 districts, 1 industrial zone, 38 communities and 98 administrative villages under the jurisdiction of 3 towns in Shunyi District, 1 street in Chaoyang District, 6 communities and 26 administrative villages under the jurisdiction of 4 districts, and 9 administrative villages under the jurisdiction of 1 district and 1 town in Tongzhou District. The details are as follows:

  I. Scope of Clearance Protection Area in Shunyi District

  (1) Sixteen communities in Shengli Street: Xingfu West Street Community, Yibin Street Community, Yibin Building First Community, Yibin Building Second Community, Qianjin Community, Taiping Community, Shengli Community, Shuangxing West District First Community, Shuangxing West District Second Community, Xixin Community, Xixin First Community, Dongxing Community First Community, Dongxing Community Second Community, Dongxing Community Third Community, Shuangxing East Community, Happiness.

  (2) Nine communities in Guangming Street: Binhe Community, Yulong garden club, Family Committee of 66055 Army, First Community in New North District, Second Community in New North District, Third Community in New North District, First Community in New South District, Second Community in New South District and Sixth Community in Yulong District.

  (3) Ten communities in Shiyuan Street: Wulicang No.1 Community, Wulicang No.2 Community, Shiyuan West Community, Shiyuan East Community, Shiyuan North District No.1 Community, Shiyuan North District No.2 Community, Shiyuan South Community, Light Automobile Committee, Yanjing Beer Manufacturers Committee and Shiyuan East Community.

  (4) Linhe Industrial Zone and 19 administrative villages in Renhe District: Shigezhuang Village, Qianjin Village, Fuxing Village, Taiping Village, Zhuangtou Village, Shimen Village, Shajing Village, Wangquansi Village, Junying Village, Meigouying Village, Shatuo Village, Hugezhuang Village, Yangjiaying Village, Wujiaying Village, Migezhuang Village, Yaopo Village, Taojiafen Village and Pinggezhuang Village.

  (5) Fourteen administrative villages in Houshayu area: Luogezhuang Village, Xitian Gezhuang Village, Yanwangzhuang Village, Xibai Xinzhuang Village, Jixiangzhuang Village, Matouzhuang Village, Houshayu Village, Qianshayu Village, Dongzhuang Village, Huoshenying Village, Blacksmith Ying Village, Kuliushu Village, Huimin Ying Village and Donggezhuang Village.

  (6) Two communities and eight administrative villages in Tianzhu area: Lianzhu garden club, Lianzhu Garden Second Community, Tianzhu Village, Xuedarenzhuang Village, Loutai Village, Gangshan Village, Yang Er Ying Village, Hualikan Village, Ershilipu Village and Xiaowang Xinzhuang Village.

  (7) Eleven administrative villages in South Faxin area: hong cun in Donghai, hong cun in Xihai, Nanjuan Village, Sanjiadian Village, Dongdulan Village, Xidulan Village, Beifaxin Village, Jiaogezhuang Village, Dajiangwa Village, Liujiahe Village and South Faxin Village.

  (8) Eleven administrative villages in Ma Po: Liangzhengjuan Village, Miaoerjuan Village, Yamen Village, Shijiaying Village, Maojiaying Village, Yaodian Village, Majuan Village, Jingjuan Village, West Ma Po Village, Baigezhuang Village and Nihe Village.

  (9) Five administrative villages in Niulanshan area: Qianyanzi Village, Yaogezhuang Village, Xianggezhuang Village, Guanzhijuan Village and Fangezhuang Village.

  (10) Seven administrative villages in Gaoliying Town: Zhangxizhuang Village, Dongmagezhuang Village, Ximagezhuang Village, Xiaxianying Village, Nanlangzhong Village, Shuipo Village and Wenying Village.

  (11) One community and nine administrative villages in Liqiao Town: Sakura Garden Community, Yinggezhuang Village, Nanbanbidian Village, Houqiao Village, Zhuangzi Ying Village, Wazi Village, Touerying Village, Sansiying Village, Zhangxin Village and Xishuxing Village.

  12. The 14 administrative villages in Zhaoquanying Town: xi xiao ying, Beilangzhong Village, Qiansangyuan Village, Housangyuan Village, Baimiao Village, Majiapu Village, Daguanzhuang Village, xiaoguanzhuang Village, Xichengezhuang Village, Zhaoquanying Village, Baofang Village, Jishanying Village, Xijiangyouying Village and Banqiao Village.  

       II. Scope of Clearance Protection Area in Chaoyang District

  (1) Four communities in the streets of the Capital Airport: South Road Xili Community, South Road Dongli Community, Xiping Street Community and Nanping Li Community.

  (2) There are 2 residential areas and 13 administrative villages in Jinzhan area: Chaoyang Farm Residential Area, No.16 Engineering Office Residential Area, Leizhuang Village, Dongcun Village, Xicun Village, Xiaodian Village, Beimafang Village, Louzizhuang Village, Shawo Village, Ligezhuang Village, Magezhuang Village, Picun Village, Dongyao Village, Caogezhuang Village and Gaoantun Village.

  (3) Six administrative villages in Sunhe area: Sunhe Village, Qianweigou Village, Houweigou Village, Kangying Village, Beidian Village and Xidian Village.

  (4) Four administrative villages in Dongba area: Sanchahe Village, Jiaozhuang Village, Dongxiaojing Village and Xixiaojing Village.

  (5) Three administrative villages in Changying Hui area: Shilipu Village, Wuliqiao Village and Caofang Village.

  III. Scope of Clearance Protection Area in Tongzhou District

  (1) Three administrative villages in Yongshun area: Beimazhuang Village, fan village Village and Wangjiachang Village.

  (2) Six administrative villages in songzhuang town: Guantou Village, Wugezhuang Village, Gequ Village, Yingezhuang Village, Regal Village and Zhaili Village.

North American box office: "Mr. Glass" topped the "Dragon Ball Super" fans.

1905 movie network news Last weekend (01.18-01.20), the box office revenue in North America totaled $129 million, up 8.2% from the previous week. Monday is Martin Luther King Memorial Day, and we will continue to have a holiday. Among the new films on the list, M Knight Shamalan’s new film "Mr. Glass" earned $40.58 million in the first three days of the first weekend, which was close to $40.01 million in the first week of "Split" in 2017 and higher than $30.33 million in the first week of "Never Die" in 2000. Not surprised or pleased. The media mostly think that the content is too full and too anxious, but there is no emotional touch. They think that they are not attracted to fans of "The Dead Robber" or "Split" and become ungrateful at both ends. Another new film is a slightly niche animated film "Dragon Ball Super: brolly". The plot is based on the animated series "Dragon Ball". After telling the story of Wukong and brolly, it is biased towards fans. In the first week, it won 10.65 million US dollars in 1233 theaters in North America, but it attracted a limited audience and was not optimistic about its subsequent box office development.

ranking

film

Weekend box office

(USD)

Cumulative box office

(USD)

Number of release weeks

this week

last week

one

new

Mr. glass

40.58 million

40.58 million

one

2

one

Uplink

15.67 million

43.98 million

2

three

new

Dragon Ball Super: brolly

10.65 million

21.07 million

one

four

2

Aquaman

10.33 million

304.3 million

five

five

four

Spider-Man: Into the Spider-Verse

7.25 million

158.2 million

six

six

three

A dog’s way home

7.11 million

21.27 million

2

seven

five

Escape Room

5.27 million

40.7 million

three

eight

six

Happy Man 2

5.24 million

158.7 million

five

nine

seven

Bumblebee

4.66 million

111.5 million

five

10

eight

Gender-oriented

3.96 million

16.87 million

four

11

nine

Mule

3.5 million

96.92 million

six

twelve

15

Green Book

2.26 million

41.97 million

10

Source: boxofficemojo


"Mr. Glass" is too full of word of mouth, and the fans of "Dragon Ball Super: brolly" are serious


Recommended star rating of Mr. Glass: ★★★

"Dragon Ball Super: brolly" Recommended star rating: ★★★ (specific fan direction)

 

On the weekend of Martin Luther King’s Day, M Knight Shamalan’s new work "Mr. Glass" earned 40.58 million US dollars at the box office in North America from Friday to Sunday, which was close to 40.01 million US dollars in the first week of "Split" in 2017 and higher than 30.33 million US dollars in the first week of "Never Die" in 2000. In all the Martin Luther King Memorial Weekends, this box office ranked third, only behind the $41 million of "Sasaki Brothers" in 2014 and the $89 million of "American Sniper" in 2015. The production cost of Mr. Glass is $20 million, and the global box office has reached $90 million. These figures undoubtedly prove Shamalan’s ability to make money again. In fact, even in the low tide of Shamalan’s poor reputation, many of his films were very profitable. For example, in 2008, the production cost of "Death" was 48 million US dollars, and the final global box office was 163 million US dollars. In 2004, the production cost of "Mystery Village" was 60 million US dollars, and the final global box office was 256 million US dollars. What he really didn’t earn was only.

 

At present, the cinema score of Mr. Glass is B, IMDb score is 7.2, MTC score is 42, and the freshness of rotten tomatoes is 36%. "Hollywood Reporter" commented: "As the final part of the trilogy, this film is like a mixed bag, twisting all the previous narrative clues into one, but unfortunately trying too hard to tell the audience that Shamalan has a very special idea on the popular comic adaptation story, but the result is not shown." "Variety" said: "It’s still very happy to see Shamalan return, but" Mr. Glass "takes up more of our time, but it can’t create any touches, which makes people feel busy and dazzling, but there are few moving moments of emotional resonance." "International Screen" thinks: "Apart from McEvoy’s performance as a smoke bomb and Bruce Willis’s convincing charm, the whole film has actually not gone far in the concept of’ what happens when people become superheroes’." Due to the poor reputation, the follow-up box office track of Mr. Glass may be more similar to the Clover Files, which was opened on the weekend of Martin Luther King’s Day in 2008. The film earned $40 million in the first week and $80 million in the local box office.

Another noteworthy new film last weekend was the classic IP cartoon "Dragon Ball Super: brolly", which was only opened in 1,233 theaters in North America, aiming at clearly attracting a specific fan base, and won $10.65 million at the box office in three days in the first weekend. The story of "Dragon Ball Super: brolly" is a continuation of the upcoming TV animation "Dragon Ball", which tells the story between Saiyan brolly and Wukong. The film was nominated for the best cartoon in the 42nd Japanese Film Academy Award and was very popular among fans. At present, the media scores and fans’ scores of all platforms are very high, with IMDb score of 8.6, MTC score of 64 and the freshness of rotten tomatoes of 80%. The Los Angeles Times said: "brolly is ready to give Dragon Ball fans everything they want in a movie, and other viewers may feel lost in this world." Midwest Film Journal also thinks: "For the novice Dragon Ball, this film provides a dazzling animation time." There are also some media that don’t like it, such as "Movie Country", which means: "This is a meaningless garbage culture animation only for fans."

 

Old movies: "Neptune" local over 300 million "Upward" has a strong box office stamina.

 

Warner Bros.’ s superhero movie Neptune has entered its fifth week. After the weekend, the film’s box office outside North Captain America: Civil War has reached 759 million US dollars, surpassing’s 745 million US dollars, and the local box office has also exceeded 300 million US dollars. At present, the film’s global total box office is 1.063 billion US dollars, which is still 3 million US dollars short. Amber Heard’s Neptune can surpass Johnny Depp’s highest-grossing Pirates of the Caribbean: The Coffin. At the same time, Aquaman is also the movie with the strongest box office stamina after Teenage Mutant Ninja Turtles: The Age of Mutations in 2014. It is expected that Aquaman will have a good room for growth before The Lego Movie 2: The Second Part and Listen to Men’s Hearts come out on February 8.

 

In the following week, Upward Bound kept quite steady, with the box office of $15.6 million in three days over the weekend, which was only 23% lower than that in the first week. Earlier, many films in kevin hart fought bravely in Martin Luther King’s weekend, such as the above-mentioned Sasaki Brothers, Customized Best Man and Sasaki Brothers 2, and so on. This time, Upward Bound was opened in this schedule one week ahead of schedule. At present, the total box office of Upward is US$ 43.98 million. As long as it exceeds the US$ 48.7 million of Supersize Beauty last year, it will become the third domestic box office of STX Entertainment after bad mother and Christmas of Bad Mom. Sony’s Spider-Man: Into the Spider-Verse currently has a global box office of US$ 322 million, which has surpassed The LEGO Batman Movie’s US$ 311 million. The production cost of Spider-Man is US$ 90 million.

 

This week’s preview: Adventure "King Boy" Playing through the thriller "Quiet" arouses expectations.


This weekend (01.25-01.27), Fox’s youth movie "King Boy" and Matthew McConaughey and Anne Hathaway’s crime thriller "Quiet" will be widely opened in North America.

 

Fox’s "The King’s Boy" tells the story of a little fat boy, Alex, who accidentally pulls out and passes on the "sword in the stone" mentioned by H. As a destined little hero, he needs to unite his friends and the legendary wizard Merlin to fight against the eccentric witch Morgana. This is a story from modern times to legend, which will be opened in more than 3,400 theaters in North America this Friday. The crime thriller "Quiet" starring Matthew McConaughey and Anne Hathaway was postponed from last October to this week. It tells the story that Baker Dill, the captain of a fishing boat, received a request from his ex-wife Karen to help her kill her violent current husband. Karen’s appearance was forgotten in Jandyr, but in fact, the current situation is also city by the sea. The film will open in more than 2500 theaters this Friday.


National Health Commission: We will summarize the experience of "sharing nurses" and guide the standardized development.

  Yangguang. com BeijingsixmoonfiveJapan News (Reporter Sun Bingjie) Recently, a new type of Internet has emerged in Shandong and Fujian.+Home-based medical model-"shared nurses" has aroused public discussion. This one is connected to the Internet.+The new medical model of hitchhiking not only brings convenience to patients, but also causes social doubts about its safety. National Health Commission, as the competent department, responded a few days ago and will summarize the experience of "sharing nurses" in various places to guide the standardized development.

  "shared nurses": a win-win situation for nurses and patients?

  Bike-sharing, familiar with the public, etc.APPSimilarly, turn on the phone.APPChoose the service you need, place an order, wait for the platform to screen, and you can enjoy the services provided by nurses or doctors in just ten minutes. This is a "shared nurse" model popular in Jinan, Shandong and other places recently.

  "shared nurse"APPWhat services can you provide? The reporter downloaded an earlier one with the words "shared nurse" on the mobile phone.APPBesides routine injections, infusions, blood collection, etc., its homepage can also provide services such as catheterization, enema, stitches removal and maternal and child care.

  

  This new type of "Internet"+The mode of "home care" is being welcomed by many users, such as Ms. Wan Juan in Beijing.APPA loyal user of. She told reporters that her family is old and young, and she rarely has time to go to the hospital.APPSolved her "trouble" to a great extent. "I have to queue up when I go to the hospital to register. The elderly and children at home are uncomfortable. I now make an appointment with doctors and nurses directly."

  At present, the shared nurses launched by various platformsappThere is little difference in functions, mainly providing on-site service for nurses. In addition to the top three hospitals, some nurses come from outpatient departments of primary hospitals. The service items are varied, but mainly include injection and infusion, dressing change and maternal and child care.

  Compared with public hospitals, the reporter noticed that nurses were shared.APPIt is generally expensive in price. Take basic services such as infusion and injection as an example. Most of themAPPOn-site service price is at150About yuan, more than hourly billing. According to the price of medical services in public hospitals in Beijing(2017edition),Adult outpatient intravenous infusion general public hospital price insevenYuan or so, only this one is close.twentyTimes.

  However, in the view of employee Zhao Fei, the current pricing is still in the "acceptable range" compared with the cost of patients queuing in the hospital. And the shared nurse model can not only provide convenience for patients, but also give patients and nurses appropriate subsidies, which can increase the income of nurses.

  "Now nurses pay more, but their income is not ideal. In particular, some nurses are too old to work at night, and theseAPPIt provides them with opportunities to realize their skills and increase their income. Yang Jie, a nurse in a hospital in Xicheng District, Beijing, told reporters.

  "Aging" gives birth to the demand for home care

  In fact, shared nursesAPPIt is not the first time that it has appeared. The upsurge of sharing economy in recent two years has also made the medical field the next outlet. Huge nursing demand and professional nursing force through "Internet"+"Shared nurses" are entering the families of ordinary people.

  The latest statistics of the National Office for Ageing, as of2017At the end of 2008, the whole country60The number of elderly people over the age of2.4Billion, accounting for the proportion of the total population.17.3%, average nearfourIndividual labor supportoneAn old man. Many elderly people suffer from chronic diseases and need regular health care; Among the hospitalized patients, at least20%~30%% of patients still need nursing after discharge.

  There is a strong demand for nurses’ home service. Mobile nursing platform provides opportunities for nurses to realize their skills. While "shared nurses" seem to be "win-win", the unsafe factors can not be ignored, mainly focusing on nurse qualifications, medical safety and so on.

  According to National Health Commission2008The Measures for the Administration of Nurses’ Professional Registration, which was implemented in, stipulates that nurses can only engage in nursing work according to the registered practice place after obtaining the Nurse’s Practice Certificate through practice registration. According to the reporter’s understanding from National Health Commission, at present, except for Beijing, Tianjin and Guangdong, which are pilot areas for regional registration of nurses, nurses in most other provinces have no multi-point qualification.

  "This means that the on-site service is actually carried out outside the registered practice place and is suspected of illegal practice." Analysis of Zhou Xuefeng, a lawyer of Beijing Jingshi Law Firm.

  In addition, how to avoid the medical risks in the nurse’s home service center? It is the key to whether the "shared nurse" platform is reliable. The reporter noticed that the current shared nursesAPPFor patients with higher risks, they will generally not take orders, and nurses will also choose orders with lower risks. Yang Jie, who has many years of nursing experience, admits that the biggest risk of door-to-door infusion lies in its uncontrollable nature, and patients may have adverse reactions during infusion. The patients’ families lack emergency rescue equipment, "not only the patients will be very dangerous, but also the disputes between doctors and patients will be difficult to sort out."

  Relevant policies are on the way.

  this yearfourmoon28On April 20, the General Office of the State Council officially released "On Promoting the Internet"+Opinions on the development of medical health. Require a sound "Internet"+Medical health "service system. Promote the integration of Internet and medical and health services from the aspects of medical treatment, public health, family doctor signing, drug supply guarantee, medical insurance settlement, medical education, popular science and artificial intelligence application. It covers many aspects of medical treatment, medicine and medical insurance.

  In an interview with a reporter from the Central Broadcasting Bureau, the relevant departments of National Health Commission pointed out that some provinces and cities with conditions have explored the "shared nurse" door-to-door service, which has solved the problem of the elderly and patients with mobility difficulties, brought convenience to the people, and is an exploration of nursing service entering the family.

  According to the forecast of the World Health Organization,2050In, China will have.35%The population of more than60Years old, which means that China is also facing strong aging pressure under the background of building a well-off society in an all-round way. In Zhao Fei’s view, aging+The limited medical resources have created many urgent needs for Chinese to see a doctor at home. "Although the’ shared nurse’ has some flaws, it has responded to some extent.The basic desire of "seeing a doctor at home". Wu Zhipan, a professor at Peking University, said, "Most norm makers are facing the Internet.+"Mode, it is inevitable to behave behind some, should set aside time. "

  Regarding whether it is legal for nurses to sign contracts with the online platform, the relevant authorities said in an interview that the multi-point practice of signing online platforms and physical medical institutions is not the same, but there is no relevant policy. National Health Commission said that the next step will be to gradually revise and improve the policies related to nurse practice management on the basis of summing up the pilot experience, combining with the promotion of graded diagnosis and treatment and the continuous deepening of medical reform. At the same time, further implement the "General Office of the State Council on promoting the Internet"+Opinions on the development of medical health, combined with the experience of exploring and developing "shared nurses" in various places, guides standardized development to meet the diversified and multi-level health needs of the public.

Ministry of Human Resources and Social Security: Strive to create diversified employment opportunities and do everything possible to create conditions for youth employment and entrepreneurship.

  Cctv newsToday (August 30th), Zhang Ying, director of the Employment Promotion Department of the Ministry of Human Resources and Social Security, answered a reporter’s question about youth employment at a policy briefing in the State Council, saying that young people are the most active and dynamic force in the whole society, and there is great potential for innovation and creation. Promoting youth employment is related to the improvement of people’s livelihood, high-quality development and the future of the country. The 14th Five-Year Plan for Employment Promotion not only emphasizes the continuous employment of college graduates, but also clearly puts forward the promotion of youth employment for the first time and makes separate arrangements.

  Zhang Ying said that the overall consideration is to promote youth employment and entrepreneurship through multiple channels through the efforts of the supply and demand sides and the support of policy services. The specific measures are as follows:

  First, focus on creating diversified employment opportunities.Expand employment and entrepreneurship opportunities in new industries, new formats and new modes, connect with the optimized industrial layout, coordinated regional development and the talent demand of enterprises in key industries, improve the demand forecasting, factor allocation and coordinated development mechanism of human resources, and support young people to find jobs and start businesses in areas that are in urgent need.

  The second is to enhance the ability of career development.Improve the job-seeking ability through career guidance, increase the guidance of career planning, career experience and job-seeking methods, and enhance the adaptability of young people in the workplace. Through vocational training, improve professional skills, expand special ability training, new vocational training, and replace training with work to enhance the growth of youth employment. Increase practical experience through employment internship, provide more internship opportunities for management and technical positions, and enhance the post competence of young people.

  The third is to focus on enhancing the pertinence of employment services.We will improve the employment service model that meets the needs of young people, and provide employment services such as job introduction according to their employment wishes, so as to improve their accuracy in choosing jobs. Open the channels of information services, organize professional and professional recruitment activities, combine online and offline, and innovate more employment service models such as "live broadcast with posts" that meet the characteristics of young people.

  The fourth is to focus on helping the difficulties.We will implement the youth employment sailing plan, provide practical guidance, classified guidance and follow-up assistance to unemployed young people, and guide them to stand on their own feet and enter the market and integrate into society. At the same time, we will provide employment assistance to some unemployed young people who are in difficulty and secure the bottom line of employment.

  College graduates have always been the most important among the youth groups. For recent college graduates, the Plan has defined a special employment and entrepreneurship support plan to continuously expand market-oriented and socialized employment channels. For previous unemployed graduates, they can also get better support through relevant measures and arrangements to promote youth employment.

  Zhang Ying said, we will do our best to create conditions for young people to find jobs and start businesses, and help them contribute to the country with their wisdom and talents, so as to forge ahead and serve the society.

Mary said that the Spring Festival Evening was like an exam, and Zhang Yimou was like a god to himself.

On February 9th, Mary, the actor who made his eighth appearance on the stage of the Spring Festival Evening, came to the interview room. She said that every time she comes to the Spring Festival Gala, like the exam, she is particularly nervous and under great pressure. When she has good works, she will be more confident in acting, but this year’s time is relatively hasty.

Mary said that it is actually more difficult for an actress to act in comedy than an actor, because she is not willing to "sell" or "play", but rather wants to start from the characters, so whether it is the structure or the character of the role, it is still more challenging to act.

Talking about the upcoming film Article 20, Mary said that he didn’t expect to cooperate with director Zhang Yimou one day. From the day he joined the group, he felt that everything was like a dream. Mary also said that Zhang Yimou’s state of filming on the spot, his unique ideas, his requirements for actors and his control of all the plays made him feel that the director is the most attractive and soul person in the crew and the soul of a movie. "I think the director is like a god to me."

Recalling that in 2023, Mary admitted that he was a model worker. Last year, there were 3 or 4 films and played some very powerful female roles. The creative process was happy, but it was also very painful. The result was very satisfactory for himself. I hope I can give myself a holiday in the new year.

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Liu Xiangdong, Shanxi’s "environmental hero", once suggested giving environmental rewards to officials.

        At about 16: 00 on March 19, CPC Central Commission for Discipline Inspection official website quoted the Shanxi Provincial Commission for Discipline Inspection as saying: With the approval of the Shanxi Provincial Party Committee, Liu Xiangdong, the former party secretary and director of the Shanxi Provincial Environmental Protection Department, was suspected of serious violation of discipline and law, and is currently under investigation.

        According to public information, Liu Xiangdong was born in 1955 and joined the work in 1970. He was born in Pingshan, Hebei. In the 1970s, he graduated from the Chinese Department of Shanxi University as a student of workers, peasants and soldiers, and then entered Shanxi TV Station and Shanxi Radio Station as an editor and reporter.

        Liu Xiangdong’s relationship with news may be related to his family.

        In a book entitled "The Bad Official’s Documentary on Environmental Protection in Liu Xiangdong", it is mentioned that Liu Xiangdong’s father Liu Shan was the editor-in-chief of Shanxi Daily.

        In December, 2004, under the care of some retired leaders in Shanxi Province and the old-timers in the press, Liu Xiangdong published Liu Shan Memorial Anthology at his own expense.

        The author of "The Bad Official’s Environmental Protection Documentary in Liu Xiangdong" once worked in a news unit and lived in the same yard with Liu Xiangdong in the 1960s and 1970s. "We get along very well, and we talk about everything."

        The author of the book wrote in the "postscript", "I think I know him better. He doesn’t have a high standard of living and little interest in his spare time. No drinking, no dancing. Mahjong can’t be rubbed, and poker can’t be played. The only hobby is to smoke cigarettes and watch martial arts novels or real kung fu movies. "

        In 1985, Liu Xiangdong, who was in his thirties, moved from the media to his official career. He successively served as deputy secretary and deputy director of the Party Committee of Taiyuan No.1 Commercial Bureau, general manager and party secretary of Taiyuan Tianlong Building. In 1991, Liu Xiangdong became the Deputy Director of Shanxi Foreign Trade Department, and later served as the Deputy Commissioner of Xinzhou Administrative Office, the Deputy Director of Provincial Trade Department, the Director of the Council of Provincial Supply and Marketing Cooperative and the Party Secretary.

        In 2006, Liu Xiangdong transferred to the environmental protection system and became the Party Secretary and Director of Shanxi Environmental Protection Bureau. People in Shanxi’s environmental protection industry said that at that time, Shanxi’s atmospheric environment and water environment were ranked last in the country, and it was also the time when environmental protection work was highly valued and began to exert its strength.

        At the beginning of taking office, Liu Xiangdong suggested that officials should be rewarded for environmental protection, which immediately caused great controversy.

        According to Phoenix Weekly, the Shanxi Provincial Environmental Protection Bureau and the Finance Department have come up with a "brilliant plan": whoever withdraws from the top 5 cities with the most serious air pollution in China will be rewarded handsomely; Cities with an air quality index ranking 10 places ahead will be awarded special prizes. The maximum amount of reward is RMB 2 million. Rewards are mainly given to individuals, mainly the principal responsible persons, leaders in charge, leaders of environmental protection departments and relevant personnel in key cities.

        The report also said that "rewarding millions" is only one of the means of Shanxi’s new environmental protection policy. Since Liu Xiangdong became the director of Shanxi Environmental Protection Bureau in March 2006, a series of severe environmental punishment measures have been introduced, and even three mayors have received an open letter from the Environmental Protection Bureau urging them to carry out environmental protection work.

        "Liu Xiangdong is an environmental hero in China" —— In June 2007, a Shanxi media published an article praising the then director of Shanxi Environmental Protection Bureau.

        In October, 2008, Liu Xiangdong won the Gold Medal of the Global Charity Alliance for his outstanding contribution to the improvement of Shanxi’s environmental quality.

        After being awarded the medal, Liu Xiangdong said that the environmental protection project is a project of people’s livelihood and virtue, and its contribution is contemporary and beneficial to the future. In one fell swoop, Shanxi got rid of the "black hat" with the first pollution in the country and put on the "green hat" again. This depends not only on the determination of "steel law enforcement" and "broken arm pollution control", but also on the cooperation of "linkage of all parties" and "joint attack" "So, this heavy medal does not belong to me personally, but to all Shanxi and the whole society."

        In December of the same year, he won the fifth China Baosteel Environmental Award.

        When Shanxi Environmental Protection Bureau recommended him as a candidate, he once introduced: He was born in Chinese major, worked as a reporter, once encouraged writing, criticized the current disadvantages, and became famous in Shanxi press; He has been galloping in the industrial and commercial field for many years. When he was in charge of Tianlong Group, Tianlong spent its moderns; After taking charge of the supply and marketing cooperative of Shanxi Province, the supply and marketing system of Shanxi ushered in the development climax of longing; He, who has been concerned about environmental protection for a long time, seems to have been born for environmental protection, and seems to have been waiting for the opportunity to die for environmental protection. At the critical moment of Shanxi’s environment, his temperament as a challenger and his style as an innovator make him a natural candidate for the provincial party committee and government to be appointed in crisis.

        After winning the prize, Liu Xiangdong said that he would donate all the 50,000 yuan prize to Shanxi Representative Office of China Environmental Protection Foundation as the first start-up fund of Shanxi Environmental Protection Award to encourage and support advanced collectives and individuals who have made outstanding contributions to Shanxi’s environmental protection.

        Liu Xiangdong’s environmental protection work has also been recognized by the old leaders.

        The book "Bad Official’s Environmental Protection Documentary in Liu Xiangdong" writes that on November 17, 2007, an old comrade who had worked in Shanxi wrote a letter to the then leaders of Shanxi Province. The letter said, "The other day, when I was in Taiyuan for a meeting, I dropped by Lvliang City and personally felt that Shanxi has changed a lot in recent years, especially the environmental quality …"

        In 2008, the State Environmental Protection Administration was "upgraded" to the Ministry of Environmental Protection, and in May of the following year, Liu Xiangdong was also changed from the former Shanxi Provincial Environmental Protection Director to the Shanxi Provincial Environmental Protection Director.

        Different from the "glorious image" established in the media, an official in the environmental protection system of Shanxi Province told The Paper (www.thepaper.cn) that he had a general impression of Liu Xiangdong and did not agree with the statement that Liu was an "environmental hero".

        Another official who often deals with Liu Xiangdong said, "It can only be said that he was a leader, and we can only obey. Now that he has been arrested, what’s the point of talking about it? "

        According to some people familiar with the matter, Liu Xiangdong has been in charge of Shanxi’s environmental protection system all the year round and has made many social figures, including some Shanxi "coal bosses".

        In March 2013, Liu Xiangdong stepped down as Party Secretary and Director of Shanxi Provincial Environmental Protection Department and was replaced by Guo Changqing.

        In July, 2013, Liu Xiangdong served as the team leader of Shanxi Provincial Committee, responsible for patrolling Lvliang, a major coal town.

        According to Lvliang Daily, on April 29th, 2014, a patrol group of the provincial party committee gave feedback to Lvliang. Liu Xiangdong, leader of a group of provincial party committee patrol, gave feedback on the patrol work. Relevant responsible comrades of the provincial party committee patrol office put forward specific and clear requirements, and Gao Weidong, secretary of the municipal party committee, presided over the meeting and delivered a speech.

        Now, it seems quite ironic.

Li Hui, the representative of the 19th National Congress: Protecting Green Water and Castle Peak with Iron Fist Pollution Control

Li Hui, deputy of the 19th National Congress and secretary of Yongzhou Municipal Committee of Hunan Province, was interviewed by CCTV reporters.

Li Hui, deputy of the 19th National Congress and secretary of Yongzhou Municipal Committee of Hunan Province, was interviewed by CCTV reporters.

  Cctv news(Reporter Tang Shiying, Liu Chunyu, Li Wenxue) "Since the 18th National Congress of the Communist Party of China, our urban and rural appearance has undergone gratifying changes. For ordinary people, the sense of gain is getting stronger and stronger, and there have been great changes in eating and living, and the smiles of ordinary people are brighter!" Li Hui, deputy of the 19th National Congress and secretary of the Yongzhou Municipal Committee of Hunan Province, said that it is the duty of a local responsible comrade to study the report of the 19th National Congress carefully. "After I go back, I will pass the voice of the party to every party member at the first time."

  Yongzhou City is located at the source of Xiangjiang River. In recent years, Yongzhou City has actively integrated into the development mode of "green development and green life". The excellent air quality rate has reached more than 90% all the year round. From January to September this year, the excellent air quality rate ranked first in the province; The city’s forest coverage rate reached 64.7%, with 8 national forest parks, 8 national wetland parks and 4 national nature reserves; The city’s surface water environmental function zones, drinking water sources and urban centralized drinking water sources have reached the standard rate of 100%. Up to now, the water quality of the Xiangjiang River has maintained the Class II water standard for 64 consecutive months, realizing the "Xiangjiang River going north and flooding the river". Ecological advantages and green advantages are accelerating into development advantages.

  Deputy Li Hui said that the changes and development of Yongzhou in recent years are due to the "four persistences" and the insistence on green development as the top priority. During the "Thirteenth Five-Year Plan" period, the city deployed 83 key ecological and environmental protection projects with a total investment of 104.2 billion yuan; Adhere to the ecological red line as the bottom line of politics. In recent years, Yongzhou City vetoed 72 projects to be stationed, with a planned total investment of more than 10 billion yuan; Insist on industrial transformation as a fundamental solution. Since 2015, Xiangjiang Paper, which has a history of nearly 60 years, has been shut down and transferred with an annual output value of nearly 1 billion yuan and a tax revenue of more than 100 million yuan. Adhere to the ecological accountability as a sharp weapon, strictly fulfill the "one post and two responsibilities", take the construction of ecological civilization and ecological priority development as the key contents of the "potential performance" assessment, and include them in the performance assessment of leading bodies and the assessment of leading cadres’ execution, so as to lead the green development with the assessment of "baton".

Li Hui, secretary of Yongzhou Municipal Committee of Hunan Province, accepted an exclusive interview with CCTV reporters.

Li Hui, secretary of Yongzhou Municipal Committee of Hunan Province, accepted an exclusive interview with CCTV reporters.

  It is such a series of measures that make Yongzhou’s ecological management and protection come to the forefront of the whole province and even the whole country.

  The report of the 19th National Congress of the Communist Party of China made a new plan of "accelerating the reform of ecological civilization system and building a beautiful China". Deputy Li Hui said that the concept of "Lucid waters and lush mountains are invaluable assets" should be firmly established, and ecological protection and economic and social development should be planned and deployed together.

  Yongzhou will conscientiously implement the spirit of the 19th National Congress of the Communist Party of China, insist on guarding the green mountains with an iron fist, promote green upgrading with industrial upgrading, write a green answer sheet with reform and innovation, and cultivate green development with green culture to ensure that Yongzhou has bluer sky, clearer water and greener mountains.

  Deputy Li Hui said that in the next step, Yongzhou will also vigorously implement the strategy of "innovation leading the rise of openness", focus on building "a new highland of innovation and opening up, a new Yongzhou with quality and vitality", highlight the "six major battles" and strive to achieve "four upgrades". Strive to reach the forefront of the province’s second phalanx in comprehensive economic strength by 2022, with an average annual growth rate of 9%, reaching about 350 billion yuan and a per capita GDP of 10,000 US dollars; The total fiscal revenue increased by 15% annually, and the total amount doubled compared with 2017, exceeding 35 billion yuan; The per capita disposable income of urban residents is close to 50 thousand yuan, and the per capita net income of farmers exceeds 15 thousand yuan; It will be built into an inter-provincial regional central city of Hunan, Guangdong and Guangxi, a national civilized city, a national garden city, a national global tourism demonstration city and a world shoemaking capital.

Juno Mak’s "Zombie" box office is over 10 million, and the results are attributed to the production team.


Zombies won a good reputation and box office.
 
    On November 5th, Beijing time, according to Hong Kong media reports, Juno Mak’s new film won a good reputation and box office, and he generously attributed the achievements to the whole production team. Juno Mak made no secret of considering making a sequel, but insisted on stopping when it was good. He laughed and said that he had been contacted by the hospital and asked to show both the II B and III versions at the same time, which made the public more interested in the film.
 
    Juno Mak’s painstaking "Directed by a Virgin" was released for 11 days, and recorded a total of 11 million Hong Kong dollars at the box office in Hong Kong and Macao, earning an average of 1 million dollars a day, which excited the staff behind the scenes.
 
Juno Mak wants to shoot other subjects.
 
    When Juno Mak was interviewed by telephone, he said with a smile: "As soon as everyone knew that there was a three-level version, they became more interested in Zombies. We were contacted by a hospital operator, preferring to let the theater level II B and level III go together. It was really unexpected." He also said that the film’s overseas box office results are also very satisfactory: "At least 80% of them have been sold. In fact, some investors have considered making a sequel, but I don’t think similar themes will be my choice for my next film, and I have scripts with other themes at hand."
 
    Although the box office was a big success, Juno Mak didn’t flatter himself. Instead, he said generously, "This success should be attributed to the whole production team, and the list to thank is really too long. What makes me feel most gratified is that this time it proves that the Hong Kong film industry can actually accommodate more themes and new forces. "
 
Publicity with the leading actor in Taiwan
 
    In addition, Juno Mak will fly to Taiwan Province with Siu-ho Chin and Chen You, the two leading actors in the play, for a three-day publicity. The local media also showed great interest in Zombies, so Juno Mak took many interviews and continued to promote it, hoping that the film would "go to the next city" when it was officially released in Taiwan Province on Friday.

Is the traffic "sneaking"? Here comes the truth. ……

Air-conditioning, watermelon, and WiFi are essential for summer homes.

Online classes, playing games and watching videos have become the daily life of friends.

Recently, there is a small partner private letter Xiaobian.

I found that my mobile phone traffic was "secretly running"

"The mobile phone is clearly connected to WiFi for 24 hours.

Why do you still generate traffic data? "

In order to protect the "money bag" of friends.

Xiaobian, this will reveal the secret for you.

Two misunderstandings

1. Some friends think that after the WiFi connection is successful, there is no need to turn off the data traffic. In fact, when the WiFi signal is unstable, it is still possible to consume traffic.

2. Some friends think that the mobile phone is still running traffic when connected to WiFi, which is either a problem with the mobile phone or a bug in the traffic. In fact, there is a problem with the mobile phone traffic settings.

1. When the WiFi is unstable or disconnected, the mobile phone may switch back to the 2G/3G/4G/5G network by default;

2. Some public WiFi has a time limit and will automatically switch back to the data network after the use time is over;

3. Due to the problem of mobile phone settings, WiFi; connection failed;

4. Some mobile phone systems will automatically switch to the data network when the WiFi connection signal is weak.

solution

1. Turn off the mobile data when connecting to the WiFi network.

2. Many smart phones will automatically open the data network when the WiFi signal is weak by default, so we’d better turn this function off.

Android system (take Huawei mobile phone as an example): Click "Settings-WLAN-WLAN+"to close it.

IOS system (for example, iOS9 and above): Click "Settings-Cellular Network-WLAN Assistant" to close it;

3. When the mobile phone is set to WLAN connection disconnection, it will prompt to use mobile data connection, such as Android system (taking Huawei mobile phone as an example), and click "Settings-Mobile Network-Mobile Data-Advanced-WLAN/Mobile Data Connection Switching Prompt-Prompt to Use Mobile Data Connection".

Today’s mobile phone traffic secrets are shared here!

Have you learned?

If you find it useful

Original title: "Traffic is" sneaking "? The truth is coming … "

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